Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22

Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic engineering and enzymatic synthesis.

By starting with God’s energy-dependent Creation of enzymes the C-C bond forming cascade can be linked from His Creation of achiral glycine to the differentiation of all cell types via the ATP-dependent Creation of RNA, and naturally occurring RNA interference (RNAi), which protects organized genomes from the virus-driven degradation of messenger RNA (mRNA).

The virus-driven degradation of mRNA is linked to all virus-driven pathology across kingdoms. Light-activated microRNA biogenesis is linked to the prevention of all virus-driven pathology via what is known to all intelligent serious scientists about the epistemic corruption that is common among theorists.

The epistemic corruption has been linked biased reporting of facts linked to therapeutic solutions for all virus-driven diseases. For example, see 1 of 207 others: Stimulation of NK Cell Activity by QuadraMune Alone and together with Metformin 5/26/22

…the invention teaches the administration of a therapeutic combination of ingredients comprising of metformin, pterostilbene, Nigella sativa, sulforaphane, and epigallocatechin-3-gallate (EGCG) to a mammal in need of natural killer cell immune modulation. In another embodiment, the invention teaches administration of said therapeutic combination to a mammal infected with said SARS-CoV-2. In some embodiments dosage of said therapeutic combination is based on inflammatory and/or immunological parameters observed in patients with COVID-19.

I reiterate: The embodiments link what is known to all intelligent serious scientists about how light-activated microRNA biogenesis must be linked to prevention or to effective treatment of virus-driven pathology.

See also: Epistemic corruption (7) 5/17/22

Also, achiral glycine in position 6 of the GnRH decapeptide links the creation of hemoglobin variants to T cell development and peripheral survival via the claims from MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 and facts about God’s ATP-dependent Creation of RNA.

For review see: Glycine and GnRH: Am I being pedantic? 12/4/14 and Epigenetic regulation of aging by glycine and GnRH 5/16/15

Moving forward, see: An insight into microRNA biogenesis and its regulatory role in plant secondary metabolism 5/17/22

MicroRNAs (miRNAs) are the class of small endogenous, essential, non-coding RNAs that riboregulate the gene expression involved in various biological processes in most eukaryotes.

In this video from 5/17/21, four games link God’s Creation of subatomic particles from His Creation of the Periodic Table to the microRNA-mediated riboregulators of gene expression and prevention of virus-driven pathology via Cytosis and the claims in “Genotype” and Cellulose.

It is obvious that others, ages 14+ have learned how the virus-driven degradation of messenger RNA is linked to immune evasion and/or the prevention of diseases via fixation of amino acid substitutions in viruses or in the species-specidic cell types of their hosts. See: Viral and cellular oncogenes promote immune evasion 1/13/22

The intelligent serious scientists who followed the extant literature on light-activated carbon fixation in cyanobacteria and microRNA-mediated protein folding chemistry understand how energy is linked to T cell development and survival of species via their nutrient-dependent pheromone regulated genetic processes of species-specific immune systems. For instance, see:

Heme Exporter FLVCR Is Required for T Cell Development and Peripheral Survival 2/15/15

All aerobic cells and organisms must synthesize heme from the amino acid glycine and the tricarboxylic acid cycle …needed for oxidative phosphorylation.

The role of heme as a prosthetic group in proteins involved in oxygen transport, electron transfer, and catalysis has been long appreciated. Heme is critical for mitochondrial oxidative phosphorylation, and heme deficiency impairs assembly of the electron chain subunits (1).

This was reported, in part, in the context of Epistemic corruption (9) 5/22/22

On 5/17/22 Hashem Al-Ghaili regurgitated the claims about microRNA-mediated protein folding chemistry, viral latency, riboregulators of gene expression and healthy longevity across kingdoms. He then placed them back into the context of gene-centric theories, which is why I claimed that he epitomizes epistemic corruption.

See his report on: RNA interference therapeutics for cardiac regeneration 10/1/21, which appeared with the title Scientists develop a potential cure for heart attacks on 5/17/22

This is the nonsense he touted.

1) “In the study, researchers have identified key genetic codes that they called microRNAs, MicroRNAs produce proteins….”
 
2) “…used lipid nanoparticles…”
 

3) “Planning to begin clinical trials within 2 years…”

microRNAs are not key genetic codes. They link light-activated carbon-fixation in cyanobacteria to peptide synthesis at the origin of life ~6000 years ago via fixation of amino acid substitutions in the organized genomes of all species on Earth and Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 via a model that revisited the architecture of RNA-peptide interactions which were detailed in my refutation of neo-Darwinian pseudoscientific nonsense.

See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13

For comparison, Therapeutic Solutions International Announces Launching of Phase III Clinical Trial for Treating COVID-19 Lung Damage Using its JadiCell(TM) Universal Donor Stem Cell Drug 5/2/22

This Phase III Clinical Trial links God’s energy-dependent Creation of the cell wall from pH-dependent fixation of amino acid substitutions to protection from virus-driven diseases across kingdoms via more than 141,520 indexed published works that mention microRNAs in the context of God’s Creation of energy as information.

The energy links light-activated microRNA-mediated protein folding chemistry to constrained viral latency in species from microbes to humans.

In Case You Missed It: Therapeutic Solutions International Inc OTCMKTS: TSOI rose 6.82% today.

Watch for my next 10-part series on Codon optimality vs systemic fraud. I will link it to the fraudulent representations in the special issue of Science Magazine published on 5/27/22 as “The Systemic Microbiome” and the molecular epigenetics section of our 1996 Hormones and Behavior review of energy-dependent microRNA-mediated stem cell creation and differentiation: From Fertilization to Adult Sexual Behavior

 

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