Summary: They placed the pseudoscientific nonsense about selection for beneficial mutations into the context of positive selection for mutations, which are caused by the virus-driven degradation of messenger RNA. The mutations have been linked to all pathology. It’s as if all theorists want to become known as “biologically uninformed science idiots” via their associations with others who have touted claims about “beneficial mutations.”

US Air Force Studying Impact of Exome Sequencing in Routine Care

Who, among my fellow veterans, and especially among others from The American Legion and The American Legion Riders, did not anticipate that the US Air Force would lead the way forward to prevention of all virus-driven pathology via the use of this technology?

The doctors will receive an educational primer in genomics and on-site genetic counseling support. After exome testing is performed on patients, their doctors will get a report listing the pathogenic and likely pathogenic variants related to dominant and recessive monogenic conditions, risks for complex diseases, and response to drugs. These results will be entered into the service members’ electronic medical records.

I was trained to become a medial laboratory scientist during the last 4 years of my 7 years in the United States Air Force (Dec. 1970-Aug. 1977).  I worked in the laboratory and examined the experimental evidence reported in published works, I learned that all pathogenic variants are caused by the virus-driven degradation of messenger RNA. I also learned that pharmacogenomic profiles have already been linked to effective treatments for virus-driven energy theft via my model of nutrient-dependent pheromone-controlled biodiversity.

See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

Conclusion:

…the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.

My model refuted every aspect of neo-Darwinian pseudoscientific nonsense, which may be why some doctors never heard about it, or why some of them don’t want to admit to what they know about effective treatments for all pathology.

During suicide prevention month, the National Commander of the American Legion focused on efforts to help reduce the number of suicides among veterans, which occur at ~ 22 each day. I was surprised to see how little response from the general public there has been since then. It’s as if no one has learned about experimental evidence of biologically-based cause and effect such as this:

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Differences in miRNA expression or structural gene variants were not detected. Results lend further support for models in which deficits in microglial, endothelial (blood-brain barrier), ATPase activity and astrocytic cell functions contribute to MDD and suicide, and identify putative pathways and mechanisms for further study in these disorders.

The only obvious link from from energy-dependent ATPase activity to cell type function in all cell types of all living genera is the anti-entropic virucidal energy of sunlight, which biophysically constrains viral latency in the context of the pheromone-controlled physiology of reproduction. That fact suggests exome sequencing data must be linked to routine case via the creation of energy, the creation of ATP and the creation of RNA.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

If the role of microRNAs is not examined in the context of virus-driven energy theft, the degradation of messenger RNA cannot be linked to all pathology. The suicide rate may never change, or it may not change until the virus-driven degradation of messenger RNA is linked to cancer and all other pathology in species from microbes to humans.

See also: exome sequencing microRNA  for examples like this:

Whole exome sequencing and single nucleotide polymorphism array analyses to identify germline alterations in genes associated with testosterone metabolism in a patient with androgen insensitivity syndrome and early-onset colorectal cancer.

If you do not agree that exome sequencing is the key to understanding the difference between energy-dependent healthy longevity and virus-driven pathology, please explain what you don’t like about the scientific approach to effective treatment and/or prevention of all pathology in the context of Precision Medicine.

See also: Energy as information and constrained endogenous RNA interference from the Labroots: Precision Medicine Virtual Conference February 22-23. 2017

Narrative: The term microRNA has been used in 58,000 indexed works. All the works support claims that link the anti-entropic virucidal energy of sunlight from endogenous RNA interference to biophysically constrained protein folding chemistry and cell type differentiation.

Abstract:

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

See for comparison: Evolutionary Analysis Reveals Number, Nature of Mutations Under Positive Selection in Cancer

The research shows that “across cancer types a relatively consistent small number of mutated genes is required to convert a single normal cell into a cancer cell, but that the specific genes chosen differ according to cancer type,” Sanger Institute Director Michael Stratton, a co-author on the study, said in a statement.

…the researchers identified almost 200 mutated genes under positive selection in cancer — a collection that included known cancer contributors and genes not previously implicated as cancer driver candidates.

They placed the pseudoscientific nonsense about selection for beneficial mutations into the context of positive selection for mutations, which are caused by the virus-driven degradation of messenger RNA. The mutations have been linked to all pathology. It’s as if all theorists want to become known as “biologically uninformed science idiots” via their associations with others who have touted claims about “beneficial mutations.”

Keep Reading