GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson’s Disease Mouse Model

Excerpt:

…genetically-modified macrophages released exosomes with incorporated GDNF that may facilitate GDNF transport into the target cells and preserve it against degradation.

published 9/17/14 and reported on 9/11/15 as:

Smart cells teach neurons damaged by Parkinson’s to heal themselves

Excerpt:

In addition to delivering GDNF, the engineered macrophages can “teach” neurons to make the protein for themselves by delivering both the tools and the instructions needed: DNA, messenger RNA and transcription factor.

MedicalXpress.com suddenly seems interested in reporting on the role of exosomes in RNA-mediated cell type differentiation, which is what I did yesterday in this blog post. Exosomes and the RNA-mediated future of medicine

See also: UNC smart cells teach neurons damaged by Parkinson’s to heal themselves

Excerpt: “By teaching immune system cells to make this protective protein, we harness the natural systems of the body to combat degenerative conditions like Parkinson’s disease,” Batrakova said.

See also: RNA-binding protein influences key mediator of cellular inflammation and stress responses

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