Faithfully repaired DNA

By: James V. Kohl | Published on: July 12, 2015

Origin and Evolution of DNA and DNA Replication Machineries

Excerpt:

…DNA replaced RNA as genetic material because it is more stable and can be repaired more faithfully.4

My comment: RNA-mediated amino acid-dependent DNA repair is nutrient-dependent. That fact need not be taken “on faith.” Without DNA repair, ecological variation could not be linked to ecological adaptations in all genera — except via the ridiculous theories invented by population geneticists.
See also:

The traits that make human beings unique

Excerpt:

That our rapidly expanding technology has allowed us all to become instant publishers means we can share such information at the touch of a button. And this transmission of ideas and technology helps us in our quest to uncover even more about ourselves.

My comment: At the touch of a button, I just shared information that attests to the fact that the traits that make human beings unique are RNA-mediated.
It was more difficult for Dobzhansky (1973) to share that information when he wrote: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla” (p. 127).
However, it is not the difficulty of sharing information that is the problem. The problem is that evolutionary theorists and big bang cosmologists typically refuse to accept the facts about the biophysically constrained chemistry of RNA-mediated amino acid-dependent changes in the context of protein folding and the physiology of reproduction in all living genera.
Thanks, also, to Karl Grammer for alerting me to this misrepresentation of what is known to serious scientists: Humans are nowhere near as special as we like to think.
Excerpt:

A species, by definition, is unique. In that trivial sense humans are unique, just as house mice are unique.

My comment: The mouse to human model links a single base pair to a nutrient-dependent RNA-mediated amino acid substitution and changes in morphological phenotypes.
See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model
Excerpt:

These two reports (Grossman et al., 2013; Kamberov et al., 2013) tell a new short story of adaptive evolution. The story begins with what was probably a nutrient-dependent variant allele that arose in central China approximately 30,000 years ago. The effect of the allele is adaptive and it is manifested in the context of an effect on sweat, skin, hair, and teeth. In other mammals, like the mouse, the effect on sweat, skin, hair, and teeth is due to an epigenetic effect of nutrients on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones.

My comment: The link to RNA-mediated changes in behavior is a single amino acid substitution during life history transitions of humans.
See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
My comment: The Val158Met amino acid substitution links changes in behavior during the life history transitions of humans to changes in the honeybee model organism of nutrient-dependent pheromone-controlled RNA-mediated cell type differentiation. “The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of the X chromosome, learning and memory, as well as conditioned responses to sensory stimuli (Kohl, 2012).” — excerpted from Kohl (2013)
With no mention of mutations and/or evolution, but from his “strident atheist” perspective, Robert Sapolsky links the honeybee model organism via olfaction and pheromones to the theory of mind in this entertaining presentation from 2009.

His story-telling, includes a reference to A Midsummer Night’s Dream, which was placed into the context of a Shakespearean adaptation by Woody Allen: A Midsummer Night’s Sex Comedy.  The movie, linked human pheromones to the complexity of interactions among the characters. See: Midsummer Nights Sex Comedy A Movie Clip Pure Animal Lust.
I was fascinated by what Woody Allen integrated into his adaptation, and wonder how much Shakespeare knew about human pheromones. Sir Paul Nurse linked the ability to communicate by pheromones to Shakespeare when he wrote: “A metaphor here would be the use of the Morse code and the telegraph to communicate messages. Pulses of information sent along the telegraph generate a code for letters and as a consequence sentences can be communicated. This converts the same signalling pathway from a simple on/off switch to a device that can transfer, for example, the works of Shakespeare.” (p. 426) Life, logic and information
Anecdotal and experimental evidence of biologically-cause and effect has since linked the light-induced de novo creation of amino acids to the RNA-mediated amino acid substitutions that differentiate all the cell types of all individuals of all genera via the conserved molecular mechanisms of biophysically constrained protein folding chemistry. Anecdotal and experimental evidence of biologically-cause and effect has also since linked my life in Las Vegas and what I learned about human pheromones from Martha McClintock and about dopamine from gamblers.
Sapolsky mentions the anticipatory dopamine response and the “Wellesley Effect,” which linked the epigenetic effects of human pheromones to changes in hormones that affect the behavior during their cycles of fertility.
When I first discussed my model of how mammalian pheromones affect behavior, Bruce McEwen told me it could not be fully validated unless I started with gene activation. I could not simply start with the GnRH decapeptide hormone, which is epigenetically effected by food odors and pheromones in all vertebrates.
Sapolsky claims that the students he addressed have a moral imperative to disseminate what they have learned from their professors, but he does not appear to have done that — unless, his professor Bruce McEwen, did not teach him to start with gene activation.
Viruses linked to gene activation became the start of my model when Greg Bear linked it to the creation of a new human subspecies in his science fiction novels: Darwin’s Radio (1999) and Darwin’s Children (2003). However, during the past two decades since publication of The Scent of Eros: Mysteries of Odor in Human Sexualitysome researchers have continued their debate about the importance of olfaction and pheromones to humans. So far as I know, they are not debating anything about biologically-based cause and effect with Sapolsky. But few researchers have supported my accurate claims about the importance of olfaction and pheromones in species from microbes to man.
See for example:

Biologist discusses the brain’s dimensional odor sensitivity

Also, thanks to Anna Di Cosmo for alerting me to this.

It is “paywalled” but if it is true, the link from microbes to crustaceans and insects via nutrient-dependent microRNAs that prevent genomic entropy caused by viral microRNAs may be clearer to other serious scientists.

However, I do not expect the truth to have any impact whatsoever on evolutionary theorists who believe in theories about beneficial mutations linked to gain of functions when mutations, which perturb protein folding, are consistently linked to loss of genes via nutrient-dependent changes in the microRNA/messenger RNA balance.

My comment: Everything published by serious scientists during the past 15 years continues to attest to the facts about how RNA-mediated cell type differentiation occurs. The facts are not going to change despite the complaints by theorists.
See: Bacteria use DNA replication to time key decision
and ‘Map of life’ predicts ET. (So where is he?)


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