“…the “holy grail” of regenerating a nerve enough for it to resume its function has been largely elusive.”
My comment: Theorists who are looking for the “holy grail” of nerve cell regeneration don’t realize that it is literally ‘right under their nose.’
The sense of smell links the anti-entropic epigenetic effects of the sun’s biological energy to nutrient-dependent DNA repair via the light-induced de novo creation of amino acids and the amino acid substitutions that differentiate all cell types in all individuals of all species. The amino acid substitutions are linked from the origins of nerve cells in C. elegans to brain development in other organisms via viruses and the entropic elasticity attributed to viral microRNAs.
If nutrient-dependent microRNAs fail to prevent the genetic entropy caused by the accumulation of viruses, deficits in DNA repair and nerve cell regeneration lead to neurodegenerative diseases, like Alzheimer’s.
Human pheromones have been linked to the pathway from food odors and pheromones to successful reproduction via brain development in all invertebrates and vertebrates. That fact seems to have escaped the notice of theorists. Evidence of interest in proteomics is a good sign that some theorists may still have a chance to contribute to scientific progress. However, their failure to recognize the fact that proteins cannot self-assemble and that nerve cells and brains cannot simply emerge via a series of beneficial mutations will probably keep their contributions to the bare minimum. Their minimal contributions differentiate the value of pseudoscientific nonsense compared to biological facts.
Scientific progress has consistently been made by those who link odors and pheromones from the anti-entropic epigenetic effects of nutrient energy to the de novo creation of olfactory receptor genes and the biodiversity of nutrient-dependent morphological and behavioral phenotypes. Biodiversity is enabled by the fixation of amino acid substitutions via the pheromone-controlled physiology of reproduction in species from microbes to man.
Welcome to the world of proteomics that’s been hiding right under your nose.
Feedback loops link odor and pheromone signaling with reproduction http://www.sciencedirect.com/science/article/pii/S0092867405009815
Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis http://www.freshpatents.com/-dt20110721ptan20110178009.php
Reproduction: A New Venue for Studying Function of Adult Neurogenesis? http://www.ncbi.nlm.nih.gov/pubmed/20887675
and Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14345.html
“…used specially developed technologies to “follow the zinc” have uncovered a previously unknown pathway the brain uses to fine-tune neural signaling—and that may play a role in Alzheimer’s and other diseases.”
My comment: What they refer to as a previously unknown pathway was linked from inhalation of a naturopathic zinc-containing anti-viral remedy to loss of olfactory acuity and specificity in people who failed to follow the instructions for use of the product. If the pathway were unknown, the instructions for use probably would not have clearly tried to prevent people from inhaling the product. The problems might have been prevented if serious scientists had examined the literature on RNA-medicated cell type differentiation, which includes our 1996 review: From Fertilization to Adult Sexual Behavior
“Another example of biological sex differences which are neither gonadal nor hormonal, however, is provided by the homologous but dimorphic zinc finger proteins ZFX and ZFY encoded on the X and Y chromosomes (North et al.,1991). An early study of human expression of ZFX and ZFY reported different transcript sizes from the two genes and this difference was even apparent in somatic tissues (Page, Disteche, Simpson, De La Chapelle, Andersson, Alitalo, Brown, Green, and Akots, 1990). ZFX and ZFY are described as “DNA-binding proteins” and via their binding of sexually dimorphic proteins, chromatin structure and transcription could be modulated in sexually dimorphic ways as a result of females having only ZFX binding events, whereas males would have a mixture of both ZFX and ZFY binding events (Fiddler, Abdel-Rahman, Rappolee, and Pergament, 1995; Lau and Chan, 1989; Zwingman, Erickson, Boyer, and Ao, 1995).”