There is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component. We can’t keep ignoring all of the evidence

–Professor Douglas Kell, Manchester University

Experts Say There’s a Herpes-Alzheimer’s Link

Excerpt:

…herpes has been linked to damage in the central nervous system and the limbic system, which is associated with mental decline and personality changes, the Telegraph reported. The experts called for a deeper investigation into the connection.

Calm down: Herpes probably isn’t going to give you Alzheimer’s

Excerpt:

…implicating HSV — a disease that already gets way more stigma than it is due — as the dastardly culprit behind a devastating disease is not based on sound science.

My comment: It wasn’t an implication. Their claims also linked HSV and other microbes from loss of olfactory acuity and specificity to all neurodegenerative diseases:

(iii) Olfactory dysfunction is an early symptom of AD [58]. The olfactory nerve, which leads to the lateral entorhinal cortex, the initial site from where characteristic AD pathology subsequently spreads through the brain [59, 60], is a likely portal of entry of HSV1 [61] and other viruses [62], as well as Chlamydia pneumoniae, into the brain [63], implicating such agents in damage to this region.

Rachel Feltman seems to keep suggesting that all evidence of virus-driven energy theft, which is linked from olfaction to entropy in all organized genomes, should be ignored.

See for comparison:

In the second part of this poster, four citations link virus-driven energy theft to all pathology. Part 3 links nine more citations and examples of biologically-based cause and effect from the Zika virus to differences in human craniofacial and behavioral phenotypes.

Zika Update

Summary: Virus found in breastmilk; another disease linked to Zika infection; some mosquitoes resistant to pesticide; genetically engineered–mosquito field trials could proceed

My comment: Will Rachel Feltman suggest that others also ignore facts about transgenerational epigenetic inheritance of the Zika virus in hopes that she can maintain some degree of credibility as a science journalist?

What Do We Actually Know About Pheromones?

Excerpt:

If you, as a human, don’t have a sense of smell, it doesn’t render you behaviorally incapable.

Excerpt:

But Kohl’s products, which he likens to food spices (“They give you an extra kick!”), make some researchers roll their eyes. Dr. Jim Pfaus, professor of psychology at Concordia University in Montreal, is one of them.

Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

My comment: The nutrient-dependent production of species-specific pheromones links everything known about the development of the gonadotropin releasing hormone (GnRH) neuronal system in mammals from luteinizing hormone and the proliferation of neural stem cells to neurogenesis during life history transitions in humans via humanized mouse models and immune therapy research.

Everything known about cell type differentiation in all living genera starts with the innate immune system of all cell types and links atoms to ecosystems. If nutrient-dependent RNA-mediated events do not lead from microRNAs to adhesion proteins and supercoiled DNA via the physiology of reproduction, individuals die and species become extinct.

A simple physical mechanism enables homeostasis in primitive cells

Excerpt:

We suggest that such systems, wherein short oligonucleotides reversibly inhibit functional RNAs, could have preceded sophisticated modern RNA regulatory mechanisms, such as those involving miRNAs.

My comment: That suggests energy-dependent hydrogen-atom transfer must already have occurred, since there is no other way currently known to link the sun’s anti-entropic virucidal energy to the supercoiled DNA that protects organized genomes from virus-driven entropy in all living genera in the context of their nutrient-dependent physiology of reproduction.

Reported as: Simple mechanism may have allowed primitive cells to maintain internal conditions

See also: Base-pairing protects DNA from UV damage 

and Ultraviolet Absorption Induces Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution

Szostak’s group seems most likely to be the next to report the link from energy-dependent hydrogen-atom transfer in DNA base pairs in solution to the creation of all cell types and the survival of all species via nutrient-dependent RNA-mediated DNA repair linked to supercoiled DNA that protects organized genomes from virus-driven entropy. For example, he already appears to know about the importance of nutrient-dependent amino acid substitutions.

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

Excerpt:

With peptides that have phenylalanine as the hydrophobic amino acid, there appears to be a minimum number of arginine residues necessary to enable localization to oleic acid membranes…

My comment: If others would simply start from the creation of the first cell in the context of quantum physics and the de novo creation of the receptors that let nutrients pass through the cell wall, they might better understand how pH-dependent life and death are determined by the balance of nutrient-dependent microRNAs that contribute to RNA-mediated DNA repair that is needed to prevent the virus-driven entropy of all organized genomes.

For comparison, see: Mitonuclear Epistasis for Development Time and its Modification by Diet in Drosophila

Abstract excerpt:

…mitonuclear epistases are context-dependent; suggesting the selective pressure acting on mitonuclear genotypes may vary with food environment in a genotype-specific manner.

Conclusion: 

We found evidence for pervasive mitonuclear effects and 3-way interactions for development time in the panel, and suggest that mitochondrial DNAs (and the genes they contain) act as capacitors to release cryptic genetic variation in alternative environments. We have uncovered interesting genotypes that will be the focus of future quantitative genetic mapping, and identified a sexual dichotomy in the relationship between phenotypic and genotypic expression. A striking outcome of these studies has been the unpredictable fitness consequences of different mitonuclear combinations. Efforts to test the vigor of mitonuclear combinations in human cell lines from diverse backgrounds could provide important information about genetic risk factors associated with mitochondrial replacement therapies in humans.

My comment: They appear to have found evidence that nutrient energy-dependent changes must be linked from microRNA flanking sequences and hydrogen-atom transfer in DNA base pairs to the physiology of reproduction, which links ecological variation to ecological adaptation in all living genera.

Darwin suspected that and stated his evidence in the context of his “conditions of life” at a time when he knew nothing about mitochondria, genes, or risk factors associated with gene editing.

See also: You are what your parents ate!

Excerpt:

In their theories on heredity and evolution, both Jean-Baptiste Lamarck and Charles Darwin explicitly stated that characteristics and traits that parents acquire during their lifetime through interaction with the environment could be passed on to their offspring. It was not until the neo-Darwinist “Synthetic Theory of Evolution,” which combines the theories of natural selection by Darwin and of genetics by Gregor Mendel, that the inheritance of acquired traits was rejected. “From the perspective of basic research, this study is so important because it proves for the first time that an acquired metabolic disorder can be passed on epigenetically to the offspring via oocytes and sperm- similar to the ideas of Lamarck and Darwin,” said Professor Johannes Beckers.

My comment: If not for the pseudoscientific nonsense about mutations and evolution touted by neo-Darwinists and human ethologists, all pathology would by now have been linked from stress to changes in pH and to viral replication via energy theft of hydrogen-atoms the must be transfered in DNA base pairs in solution to link RNA-mediated amino acid substitutions to the supercoiled DNA that protects all organized genomes in all living genera from virus-driven entropy.

 

 

 

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