2/10/21
Researchers who share the Abrahamic faiths have refuted the pseudoscientific nonsense touted by all atheists. See: microRNA 115, 376 results

There are currently

1052 results for microRNA and Israel
2,063 results for microRNA and Iran
2414 results for microRNA and Korea

For a historical perspective on what is known to all intelligent serious scientists about biophysically constrained viral latency across kingdoms see the references from:

Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency 2/8/21

In summary, miR-138 targets ICP0, Oct-1 and Foxc1 to repress HSV-1 lytic cycle genes and promote epigenetic gene silencing, which together enable favourable conditions for latent infection.

See also: Latency-Associated Transcript-Derived MicroRNAs in Herpes Simplex Virus Type 1 Target SMAD3 and SMAD4 in TGF-β/Smad Signaling Pathway 2/6/21

During its latent infection, HSV-1 produces only a miRNA precursor called LAT, which encodes six distinct miRNAs.

Conclusion: Our findings display that LAT negatively regulates TGF-β/Smad through targeting SMAD3 and SMAD4 by its miRNAs.

The claims from researchers in Iran forced the admissions from researchers in the USA and in China who collaborated to indirectly admit that the obvious cure for all virus-driven pathology was placed into the context of naturally occurring light-activated carbon fixation and patented as: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

For comparison to the patent for what naturally occurs in the context of biophysically constrained endogenous retroviruses and viral latency, see:

Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21

…the availability of tRNAs and charged amino acids has been associated with translation efficiency and mRNA stability in vertebrates [12, 22, 24, 31, 56]. As such, it will be important to integrate tRNA profiles into our model predicting mRNA stability.

This model predicts how God’s Creation of energy-as-information has been linked from His Creation of sunlight and humidity to mRNA stability since 1964.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” 

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The ATP-dependent synthesis of RNA was linked to RNA-mediated cell type differentiation across kingdoms in From Fertilization to Adult Sexual Behavior (1996)

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

pre-mRNAs are now called microRNAs and they have predictably been linked to sympatric speciation via food energy-dependent pheromone-regulated genetic processes of reproduction and niche construction in species from microbes to mammals.

See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13

This model details how chemical ecology drives adaptive evolution via: (1) ecological niche construction, (2) social niche construction, (3) neurogenic niche construction, and (4) socio-cognitive niche construction. This model exemplifies the epigenetic effects of olfactory/pheromonal conditioning, which alters genetically predisposed, nutrient-dependent, hormone-driven mammalian behavior and choices for pheromones that control reproduction via their effects on luteinizing hormone (LH) and systems biology.

Niche construction was linked to biophysical constraints on supercoiled DNA in Structural diversity of supercoiled DNA 10/12/15

Reported as: How Strange Twists in DNA Orchestrate Life

Simply twisting DNA can expose internal bases to the outside, without the aid of any proteins.

Quantum coherence has since been linked to coherently organized biology via  energy-depedent Peptide synthesis at the origin of life 11/13/20 and Visualizing a protonated RNA state that modulates microRNA-21 maturation 

See also: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrientdependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

The Regulation of host and virus genes by neuronal miR-138 [which] favours herpes simplex virus 1 latency has been placed into the context of naturally occurring light-activated carbon fixation and viral latency across kingdoms via plant growth and epigenetic effects on tumor cell lines.

See: Plant microRNAs from Moringa oleifera regulate immune response and HIV infection (unpublished) and Effect of microvesicles from Moringa oleifera containing miRNA on proliferation and apoptosis in tumor cell lines 6/4/20, which was indexed on 2/10/21.

Delayed indexing of another article may have prevented intelligent serious scientists from discussing The role of noncoding RNAs in epithelial cancer 3/12/20.  Both of the two most recently indexed articles published in Cell Death Discovery attest to the fact that discussion of a paradigm shift was deliberately postponed to alter the course of the 2021 US Presidential election.

See Impeaching the God of Abraham (2) in prep

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