Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters 12/31/20 & indexed on 2/22/21 announced
“…a functional cure for HIV.”
“The RNA polymerase III promoters H1, 7SK, and U6…”
were linked to the cure or the effective treatment of all virus-driven diseases via the patent for naturally occurring RNAi.
5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition… (in which nearly identical copies can be problematic).
The microRNA-mediated cure for HIV will come as no surprise to those who realize that information on the cure has been suppressed in the curated_news since 2005.
See: The RNAi Cure? 7/1/05
The announcement of the cure will soon be followed by evidence that RNAi biophysically constrains viral latency across kingdoms presented in the context of this STEM toy for ages 14+ Genotype: A Mendelian Genetics Game
Here are examples of how microRNA-mediated biophysical constraints on fixation of amino acid substitutions in organized genomes have been linked from chromosomal rearrangements to ecological adaptations via sympatric speciation across kingdoms since the claims made by Thomas Hunt Morgan in 1910.
The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes.
Two fixed differences among 597 amino acids drive a Val73Ile and Ala552Thr (valine to alanine) polymorphism in ZAL2m that distinguish its morphological and behavioral phenotype from ZAL2.
The nonparasitic nematode Caenorhabditis elegans expresses PC-modified N-linked glycans, offering an attractive model to study the biology of PC-modification.
For an example of how conserved ion and amino acid transporters were linked from brain development to differences in primate behavior, see: Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment 2/12/21
NOVA1 regulates alternative splicing in the developing nervous system and is a master regulator of splicing genes responsible for synapse formation.
“…replaced the modern human allele of the NOVA1 gene with the ancestral allele…which contains a single-nucleotide substitution at position 200 that causes an isoleucine-to-valine change.” They placed the nutrient-dependent change back into the context of their stupid theory about the evolution of modern humans from extinct lineages of Neanderthals and Denisovans.
Their stupid neo-Darwinian evolutionary theory was reported outside the context of a food energy-dependent pheromone-regulated base-pair alteration, which was referred to as a genetic change. The genetic change was reported in the context of the fixation of one amino acid substitution.
“It’s fascinating to see that a single base-pair alteration in human DNA can change how the brain is wired,” said Muotri,
The single base-pair change was also reported as: Neanderthal-like ‘mini-brains’ created in lab with CRISPR
That difference swaps a single amino acid in the NOVA1 protein made by the archaic organoids.
The difference is subtle—swapping in a closely related amino acid at a single location in the gene—but it is a difference. (For those who care, it’s isoleucine to valine.)
Those who care about food energy-dependent pheromone-regulated genetic processes that link fixation of amino acid substitutions, such as the change from isoleucine to valine, to biophysically constrained healthy longevity across kingdoms may want to see for comparison:
The epigenetic effects of olfactory/pheromonal input calibrate and standardize molecular mechanisms for genetically predisposed receptor-mediated changes in intracellular signaling and stochastic gene expression…
Figure 1 from my mammalian model, which starts with God’s Creation of sunlight and water, presciently expanded on this representation from computational biologists in Haplotype-resolved diverse human genomes and integrated analysis of structural variation 2/25/21
These findings allow us to establish their population frequency, identify ancestral haplotypes, and discover new associations with respect to gene expression, splicing, and candidate disease loci. The work provides fundamental new insights into the structure, variation, and mutation of the human genome providing a framework for more systematic analyses of thousands of human genomes going forward.
Their work shows how foolish it is to not start with God’s Creation of sunlight and water. They start from a gene-centric theory and end with nothing more useful to any intelligent serious scientist than all the gene-centric theories from the past with one exception.
It is clear that these researchers know that the virus-driven degradation of messenger RNA has been linked from mutations to all pathology and that they do not want others to learn that their integrated analysis of structural variation is energy-dependent and biophysically constrained in the context of pH and Visualizing a protonated RNA state that modulates microRNA-21 maturation10/26/20