NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program and Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions
were reported as:
1) …the brain is also one of the most complex organs in the body, and very little is understood about the molecular pathways that guide its development.
2) “This is a significant step towards understanding the relationship between DNA sequence, epigenetic changes and cell fate. It not only sheds new light on the formation of the brain during embryonic development but also opens up novel avenues for regenerative therapy.”
My comment: Significant steps towards understanding how the anti-entropic energy of the sun links epigenetic changes to cell fate in the context of an atoms to ecosystems model have led serious scientists to conclusions that were predicted by Schrodinger in What is Life?
1) We know definitely, today, that Darwin was mistaken in regarding the small, continuous, accidental variations, that are bound to occur even in the most homogeneous population, as the material on which natural selection works. For it has been proved that they are not inherited.
2) What then is that precious something contained in our food which keeps us from death?
3) Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight)
My comment: Anti-entropic nutrient energy-dependent epigenetic effects link the speed of ultraviolet (UV) light on contact with water to the creation of nucleic acids and the speed of infrared (IR) light to virucidal effects that promote RNA-mediated DNA repair in all living genera. Nutrient-dependent DNA repair links top-down causation from ecological variation and the sun’s biological energy to the physiology of reproduction and ecological adaptations.
Serious scientists have learned that the DNA double helix is not static, which is why only pseudoscientists continue to report vague links between mutations and/or natural selection that they claim somehow lead to the creation of all morphological phenotypes and behavioral phenotypes, which are manifested in biodiversity.
See: 42Evolution, which was reported as Evolution website sets out to tackle great scientific unknowns
Excerpt (with my emphasis):
The site was created by a team led by Simon Conway Morris…. “Evolution is true, and if it didn’t happen, we wouldn’t be here,” he said. “Like all the sciences, evolution is constantly, well, evolving. New insights and unexpected discoveries combine with seeing old things in a completely new light. It is active, dynamic, changing and unpredictable. We wanted to create a website that captures the excitement and thrill of that exploration.”
My comment: They are fighting desperately to avoid being accurately described as biologically uninformed science idiots.
See for comparison (with my emphasis):
IF under changing conditions of life organic beings present individual differences in almost every part of their structure, and this cannot be disputed; if there be, owing to their geometrical rate of increase, a severe struggle for life at some age, season, or year, and this certainly cannot be disputed; then, considering the infinite complexity of the relations of all organic beings to each other and to their conditions of life, causing an infinite diversity in structure, constitution, and habits, to be advantageous to them, it would be a most extraordinary fact if no variations had ever occurred useful to each being’s own welfare, in the same manner as so many variations have occurred useful to man. But if variations useful to any organic being ever do occur, assuredly individuals thus characterised will have the best chance of being preserved in the struggle for life; and from the strong principle of inheritance, these will tend to produce offspring similarly characterised. This principle of preservation, or the survival of the fittest, I have called Natural Selection. — Charles Darwin
…the greater variability of species having wider ranges than of those with restricted ranges, lead to the conclusion that variability is generally related to the conditions of life to which each species has been exposed during several successive generations. — Charles Darwin
When a variation is of the slightest use to any being, we cannot tell how much to attribute to the accumulative action of natural selection, and how much to the definite action of the conditions of life. — Charles Darwin
Instances could be given of similar varieties being produced from the same species under external conditions of life as different as can well be conceived; and, on the other hand, of dissimilar varieties being produced under apparently the same external conditions. Again, innumerable instances are known to every naturalist, of species keeping true, or not varying at all, although living under the most opposite climates. Such considerations as these incline me to lay less weight on the direct action of the surrounding conditions, than on a tendency to vary, due to causes of which we are quite ignorant. — Charles Darwin
By my theory these allied species are descended from a common parent; and during the process of modification, each has become adapted to the conditions of life of its own region, and has supplanted and exterminated its original parent-form and all the transitional varieties between its past and present states. — Charles Darwin
Summary: Darwin attributed all variation to unknown “conditions of life.” Only after the “conditions of life” were met could natural selection occur. He knew nothing of DNA, which means he knew nothing about the mutations that pseudoscientists still claim lead to the evolution of one species from a different species via natural selection. The pseudoscientists bastardized the entirety of Darwin’s works and turned his observations into the “Modern Synthesis” based on de Vries 1904 definition of mutation.
See for comparison:
“Advances in simulation are bringing us closer to the definition of a theoretical model that will allows us to simulate key aspects of cell life, therefore approaching the dream of describing the behaviour of organisms only based on the basic rules of physics and chemistry,” says Modesto Orozco…
This is the first mechanical explanation at the atomic level of an epigenetic effect, one of the most important, that connects an epigenetic modification with a phenotypic effect,” assures Orozco. “This leads us to believe that there is a similar explanation for other epigenetic modifications. There may be a very basic mechanism that accounts for the effect that they have on gene structure and expression,” he concludes.
My comment: The “first mechanical explanation” links epigenetic effects from atoms to ecosystems via what is currently known to other serious scientists. Nutrient-dependent biophysically constrained protein folding chemistry links microRNAs to protection against virus-driven genomic entropy. Protection against entropy arises only in the context of RNA-mediated events linked to supercoiled DNA via the speed of UV light on contact with water and the speed of IR light, which is linked to penetration of cells in different tissues of different organs in different organ systems via penetration of human skin, which is the largest organ of any human organ system.
Photobiomodulation: Laser Therapy for the Nervous System (free registration required)
The use of “low level” light applications, termed photobiomodulation (PBM), as a noninvasive, neuro-restorative therapy has potential to revolutionize repair of the injured nervous system. Experiments on the use of PBM to repair injured spinal cords and peripheral nerves will be discussed, along with the scientific basis for this improvement.
Light applied transcutaneously penetrates to the level of the spinal cord. Transmission spectra revealed that peak transmission through all tissue layers overlying the spinal cord was at 810 nm, with minimal absorption by blood and water. Axonal regeneration and functional recovery in various models of spinal cord injury was supported by 810 nm wavelength light. Genes involved in the immune response, cellular proliferation and growth factor receptors were significantly altered by PBM after spinal cord injury.
My comment: Given what is known to serious scientists about the obvious links from the sun’s biological energy to the physics, chemistry, and conserved molecular mechanisms that are the basis of what is known about biologically-based cause and effect, how much longer should we expect the pseudoscientific nonsense about mutations and evolution to be touted. Did that nonsense ever make sense to anyone who was not biologically uninformed?