Summary: It seems likely that Schrodinger’s anti-entropic virucidal effect of sunlight will be linked to the RNA-mediated de novo creation of all organized genomes and the maintenance of the “spotless epigenome” in this presentation later today. If so, even theorists and other pseudoscientists who planned to “March for Science” will finally be seen in the context of Dobzhansky’s claims about the “…light of evolution.”

Erasing Epigenetic Marks: Eternal Sunshine of the Spotless Epigenome

Topics to be covered:

  • The variety of epigenetic modifications and their influence on gene expression
  • How editing or erasing epigenetic marks might be used in a therapeutic manner

Topics already covered elsewhere: IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography was reported as:  Atomic structure reveals how cells translate environmental signals

The team identified an amino acid sequence in the leaflet that is conserved in parasites, suggesting structural insights that may assist in drug discovery for these devastating conditions.

Case for the genetic code as a triplet of triplets was reported as: Reading the genetic code depends on context

University of Utah biologists now suggest that connecting amino acids to make proteins in ribosomes, the cell’s protein factories, may in fact be influenced by sets of three triplets – a “triplet of triplets” that provide crucial context for the ribosome.

Placing the atomic structure of any functional protein into the context of energy-dependent changes in RNA-mediated amino acid substitutions links natural selection for energy-dependent codon optimality to all biodiversity. That fact about natural selection refutes neo-Darwinian theories by making the link from virus-driven energy theft to the degradation of messenger RNA the obvious link from mutations to all pathology.

It seems likely that the virucidal anti-entropic effect of sunlight will be linked to the creation and maintenance of the spotless epigenome in this presentation later today.  Hopefully, they will mention that femtosecond blasts of UV light appear to biophysically constrain energy-dependent protein folding chemistry.  For instance, see also: UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair

 

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