See: Energy as information and constrained endogenous RNA interference

Published on 15 Feb 2017 by  LabRoots

(1) The text of the narration, (2) the text from the poster, and 3) links to all cited works are here Energy as information and constrained endogenous RNA interference (4)

Introduction: The term microRNA has been used in 58,000 indexed works. All the works support claims that link the anti-entropic virucidal energy of sunlight from endogenous RNA interference to biophysically constrained protein folding chemistry and cell type differentiation.

Summary: Light-activated endogenous substrates in all cell types of all living genera link oxidative phosphorylation and photosynthetic phosphorylation from the creation of ATP to the creation of microRNAs, the creation of enzymes, and the energy-dependent enzymatic creation and fixation of RNA-mediated amino acid substitutions. The substitutions differentiate the cell types of all living genera. Energy-dependent fixation of RNA-mediated amino acid substitutions biophysically constrain viral latency.

Nearly 12,000 more articles have since been published that link the energy-dependent creation of microRNAs to healthy longevity via the physiology of reproduction. See items: 1 to 20 of 69935. Some of the newer articles also help to clearly link the virus-driven theft of quantized energy from the degradation of messenger RNA to mutations and all pathology

Simply put, the anti-entropic virucidal energy of sunlight is required for photophosphorylation and fixation of RNA-mediated amino acid substitutions in the context of the physiology of reproduction. In species from microbes to humans, the quantized energy from sunlight is linked from the physiology of reproduction in plants to the pheromone-controlled physiology of reproduction and all morphological and behavioral diversity.

See for comparison: Church Speaks: A Conversation With George Church [2.14.18]

Listen for the claim at 15:00 about the biggest energy creators and the claim at 15:10 that the cyanobacteria fix light.

See the transcript for comparison with my emphasis:

The cyanobacteria fix [carbon via] light as well or better than land plants. Under ideal circumstances, they can be maybe seven to ten times more productive per photon. . . .

I reiterate: George Church claims cyanobacteria fix light and the transcript claims cyanobacteria fix [carbon via] light.

The rest of the conversation suggests that light-activated carbon fixation in cyanobacteria automagically evolved.

Is that what George Church believes, or is that what these people want you to think that George Church believes?

See for comparison (both articles were co-authored by George Church and SW “Penny” Chisholm).

(2007) Genome-wide expression dynamics of a marine virus and host reveal features of co-evolution.
(2013) Quantification of microRNA expression with next-generation sequencing.

SW Chisholm and others subsequently published Gene Expression Patterns during Light and Dark Infection of Prochlorococcus by Cyanophage (2016)

Photosynthetic electron transport (PET) proteins are compared to the virus-augmented (aka phage- augmented) production of NADPH via the pentose phosphate pathway (PPP).

NADP is the acronym for “nicotinamide adenine dinucleotide phosphate.” It is a coenzyme composed of ribosylnicotinamide 5′-phosphate (NMN) coupled by pyrophosphate linkage to the 5′-phosphate adenosine 2′,5′-bisphosphate. Nicotinamide adenine dinucleotide phosphate plus hydrogen (NADP+) and reduced nicotinamide adenine dinucleotide phosphate(NADPH) exemplify the energy-dependent dynamics of cellular life that must be linked from hydrogen atom transfer in DNA base pairs to RNA-mediated repair of DNA damage. NADPH serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). The link from sunlight and the food energy-dependent transfer of electrons to ecosystems is clarified in this excerpt:

…both PET production of NADPH and its consumption by carbon fixation are putatively repressed during phage infection in light. Transcriptomic evidence is thus consistent with cyclic photophosphorylation using oxygen as the terminal electron acceptor as the dominant mode of PET under infection, with ATP from PET and NADPH from the PPP producing the energy and reducing equivalents for phage nucleotide biosynthesis and replication.

Simply put, without the anti-entropic virucidal energy of sunlight, the creation of ATP and the energy-dependent fixation of RNA-mediated amino acid substitutions could not be linked from supercoiled DNA to protection from the virus-driven degradation of messenger RNA that links mutations to all pathology.

George Church skips past the facts about the energy-dependent creation of ATP that link sunlight to energy-dependent ecological adaptations in all living genera via the physiology of reproduction and autophagy.

See for comparison: A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration (2016) which is exemplified in this video representation: Meet the creature that can regenerate its brain and resist cancer (2017).

Remember, George Church is a coauthor of Quantification of microRNA expression with next-generation sequencing (2013) However, he may have no expertise in any area of ecology that requires an energy source to be linked from ecological variation to biophysically constrained viral latency and ecological adaptations in all living genera.

To be continued as: Light-activated carbon fixation did not evolve (2)



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