Summary: Dobzhansky was joking about the time it would take for the creation of light to cause the energy-dependent fixation of RNA-mediated amino acid substitutions, which link food energy to the creation of enyzmes that metabolized food. His joke extends from the creation of sunlight — as the “light of evolution” — to the species-specific pheromone-controlled physiology of reproduction and cell type differentiation in chimpanzees and humans compared to gorillas via one amino acid substitution. The joke was played on theorists who, in 1973, still believed that mutations could be linked to evolution despite the claims in Schroedinger: What is Life? (1944).

See: Light-activated carbon fixation did not evolve (3),(2),(1) and RNA mediated molecular epigenetics and virus driven entropy and The origin of information (2)

For comparison, see: Genome editor CRISPR’s latest trick? Offering a sharper snapshot of activity inside the cell

…this tool can record exposure to light, antibiotics, and viral infection or document internal molecular events.

The “tool” links the anti-entropic virucidal energy of sunlight to the creation of enzymes, which link the metabolism of food energy to the physiology of reproduction in the context of autophagy and viral latency.

The facts about autophagy and biophysically constrained viral latency have been placed into the context of phage-activated continuous evolution (PACE) by people who do not want others to learn the facts about how autophagy protects all organized genome from the virus-driven degradation of messenger RNA.

See: Evolution in Action – Literally

The idea is that you use bacteriophage as your vehicle for evolving proteins, because of their extremely short generation time. These infect E. coli bacteria, and the two of them are modified in this system so that you can use selection pressure to get to a protein with specific binding properties. It’s been used to look at protease inhibitor resistance and DNA-binding specificity, and now it’s put to work for a protein-protein interaction.

All protein-protein interactions are energy-dependent, RNA-mediated and biophysically constrained in the context of the physiology of reproduction and transgenerational epigenetic inheritance.

See for contrast: Church Speaks George Church [2.14.18]

  1. Maybe it would help if the very top scientists believed in neo-Darwinism or something.
  2. We found the enzymes that occur in nature, which was not obvious, and both companies have patents on making those alkanes.

Top scientists who believe in neo-Darwinism are more likely to believe Church’s claim that the anti-entropic energy of sunlight was not the obvious link to the creation of enzymes and all biophysically constrained life on Earth. The creation of enzymes was required to biophysically constrain viral latency.

Cytosis: A Cell Biology Board Game: A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See: Regulation of the unfolded protein response by noncoding RNA

See: Endoplasmic reticulum stress signaling: the microRNA connection

See also: ER homeostasis and autophagy

The endoplasmic reticulum (ER) is a key site for lipid biosynthesis and folding of nascent transmembrane and secretory proteins. These processes are maintained by careful homeostatic control of the environment within the ER lumen. Signalling sensors within the ER detect perturbations within the lumen (ER stress) and employ downstream signalling cascades that engage effector mechanisms to restore homeostasis. The most studied signalling mechanism that the ER employs is the unfolded protein response (UPR), which is known to increase a number of effector mechanisms, including autophagy.

Place the unfolded protein response (UPR) into the context of how virus-driven energy theft links the degradation of messenger RNA from mutations to all pathology. Link femotosecond blasts of ultraviolet light to the creation of enzymes and energy-dependent RNA-mediated DNA repair to complete the picture of creation vs neo-Darwinism.

See: UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair

If you are a top scientist who believes in neo-Darwinism, retire as soon as possible to avoid the ridicule that will be linked to the lack of funding for your so-called research.

See also: miRs-103/107 regulate autophagy in the epidermis

We found that antagomir-107 treatment in epidermis: (i) depleted endogenous miR-107; (ii) increased GFP-LC3 puncta in epidermal basal layers of GFP-LC3 transgenic mice, indicative of an accumulation of autophagosomes; (iii) inhibited LC3 turnover and increased p62, suggesting an inhibition of autophagy flux; and (iv) increased phosphorylated dynamin (p-dynamin, an inactive form), a key enzyme in end-stage autophagy. Conversely, miR-107 mimic treatment in mouse epidermis: decreased GFP-LC3 puncta in basal layer as well as p62 protein levels; and diminished p-dynamin, indicative of activation of this enzyme.

See also: CCPG1: A new breed of autophagy cargo receptor: 3:00pm GMT / 10:00am EST / 7:00am PST on Thursday 1st March

The anti-entropic energy-dependent creation of receptors is enzyme-dependent and RNA-mediated in the context of the physiology of reproduction and autophagy, which biophysically constrains viral latency.

The overwhelming complexity prevents most attempts to link quantum physics from quantum chemistry to the molecular mechanisms of epigenetically-effected cancer prevention and treatment. Despite that fact, prevention and effective treatments will continue to link the speed of light on contact with water from hydrogen-atom transfer in DNA base pairs in solution via the creation of microRNAs linked to biophysically constrained viral latency.

Do you remember what Barry J. Marshall did to link H. pylori to prevention of gastric cancer?

See: Neutrons identify critical details in bacterial enzyme implicated in gastric cancer

Ronning’s team focused on H. pylori’s use of a unique biosynthetic pathway to synthesize vitamin K2, which aids in the electron transfer processes, or chemical reactions, of all organisms.

Ronning’s team linked Barry J. Marshall’s energy-dependent changes (e,g., hydrogen-atom transfer in DNA base pairs in solution) from electrons to ecosystems and healthy longevity in all living genera via the physiology of pheromone-controlled reproduction in species from microbes to humans.

I asked the evolutionary theorist, John Hewitt (a so-called science journalist): “Are you still planning to do that by starting with the magical creation of selenocysteine?”

I’ve heard nothing from him, since then.

See also: Is Maternal Food Security a Predictor of Food and Drink Intake Among Toddlers in Oregon? (2012)

CDC Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

The 35-year-old author works as a team lead for the CDC’s Division of Population Health.

Authorities say he called in sick on February 12, 2018 and has not been heard from since.

In 2014 he was the first author of: Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states

This work adds to a growing body of research suggesting that ACEs may contribute to health problems later in life and suggesting a need for program and policy solutions.

The link from the anti-entropic virucidal energy of sunlight to healthy longevity and the link from stress-induced biophysical constraint-breaking mutations reaffirms that suggestion.

Cunningham’s brother, Anterio Cunningham, does not want to assume the worst, yet he is worried something horrible has happened for him to leave his family and prized job with no notice.

The CDC did not immediately respond to ABC News’ request for comment.

Anyone with information is urged to call 911 or the Atlanta Police Homicide/Adult Missing Persons Unit at 404-546-4235.

The need for program and policy solutions at the CDC could bring the current practice of medicine to an end. The end requires all practitioners to acknowledge the facts about disease control. The facts link the creation of sunlight from fixation of light in cyanobacteria to the physiology of reproduction in humans and to all biodiversity via biophysically constrained viral latency.

See also: Nothing in Biology Makes Any Sense Except in the Light of Evolution (1973)

 I am a creationist and an evolutionist. Evolution is God’s, or Nature’s, method of Creation.

Dozhansky supposedly assumed that:

Creation is not an event that happened in 4004 B.C.; it is a process that began some 10 billion years ago and is still under way.

But he may also have been joking. He wrote:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

Dobzhansky was joking about the time it would take for the creation of light to cause the energy-dependent fixation of RNA-mediated amino acid substitutions, which link food energy to the creation of enyzmes that metabolized food. His joke extends from the creation of sunlight — as the “light of evolution” — to the species-specific pheromone-controlled physiology of reproduction and cell type differentiation in chimpanzees and humans compared to gorillas via one amino acid substitution. The joke was played on theorists who, in 1973, still believed that mutations could be linked to evolution despite the claims in Schroedinger: What is Life? (1944).

Anyone who places Dobzhansky’s claims from 1964 and the claims of McEwen et al. (1964) into the context of Frohlich’s assertions in 1968 would close the door on evolutionists in three steps.

Dobzhansky compared theorists to bird watchers and butterfly collectors.

McEwen et al., (1964) linked the creation of ATP to the creation of RNA.

Frohlich (1968) linked the creation of RNA to all biophysically constrained biodiversity.

The cell biology game “Cytosis” can be used to teach people like George Church about cell biology. Alternatively, Church could ask a serious scientist what was known about the energy-dependent creation of naturally occurring enzymes.

For comparison, retracted works by Jack Szostak’s group are the only works that might make that fact not obvious (e.g., to other theorists). Serious scientists know that all enzymes naturally occur in the context of their energy-dependent microRNA-mediated creation. If George Church shared Dobzhanky’s creationist beliefs, he might have avoided the shame that comes from his claim that it was not obvious where all naturally occurring enzymes come from.

See: Retraction Watch Also reported as: Oops! Scientific retraction a major blow to evolution theory

Szostak’s study reopens what is perhaps the largest hole in evolutionary theory, as scientists remain unable to explain how the building blocks of life were “spontaneously” created.

Jack W. Szostak—a professor of chemistry and chemical biology at Harvard University,  shared the 2009 Nobel Prize in Physiology or Medicine. It seems likely that he influenced the works by George Church — also at Harvard, and the claims Church made about the “not obvious” creation of naturally created enzymes.

See for comparison: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism

Reported as: Researchers may have solved origin-of-life conundrum

…the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given rise to most of life’s building blocks simultaneously.

The difference between George Church’s neo-Darwinian approach, and the approach that serious scientists have taken, may be as simple as the difference between a creationist and an evolutionary theorist.

 

For comparison, see: What is life when it is not protected from virus driven entropy Published on 30 Mar 2016

Poster: The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

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