Long-term adaptation replaces evolution (3)
(click to enlarge)
Summary: Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing.
Other pseudoscientists have taken a step towards refuting Koonin’s moronic claim with publication of:
A mammalian blood odor component serves as an approach-avoidance cue across phylum border – from flies to humans
The odor of E2D is sufficient to elicit approach response in blood-seeking animals. (A) Chemical structure of trans-4,5-epoxy-(E)-2-decenal (E2D). (B) Schematic drawing of the Y maze olfactory assay used for the fly behavioral experiment. (C) Mean percentage of flies choosing between E2D in a background of host odor and host odor only (left) and between E2D and cattle blood both in a host background. (D) A wolf displaying biting on the scented log, one of the eleven behaviors present in the ethogram. (E) Mean total number of interactions during a session with the four odor stimuli for the wolf pack. Error bars indicate standard error of the mean (SEM). *p < 0.05, ***p < 0.001.
Conclusion:
Taken together, our results strongly suggest that E2D is a blood signature substance that serves as an approach-avoidance cue across phylum borders; it elicits approach responses in blood-feeding invertebrates as well as in mammalian predators, while eliciting avoidance behavior in mammalian prey species. These results demonstrate the existence of a cross-species food- and alarm cue that affects behavior in both human and non-human animals alike.
Reported as: A universal food and alarm cue found in mammalian blood
The omnipresent adaptation to E2D indicates that the selection pressure for this chemical cue is preserved through evolution. This can shed light on human evolution, our formation as a species. “Our finding in humans fits in with the paleontological data showing that early primates were small-bodied insectivores. There is no question that humans are opportunistic predators, but we probably evolved from a prey species and some aspects of this trait lingers on,” says principal investigator Johan Lundström, associate professor at the Karolinska Institutet in Sweden.
Ecological variations are linked to ecological adaptations via what is known to serious scientists about quantum physics, which recently were placed into the context of observations that link electrons to ecosystems in all living genera via the 2017 Nobel Prize-winning cryo-EM technology. With the help of many others and also via my monographs and my presentations during the past 25 years this fact has become perfectly clear. The human ability to detect DNA differences in tissue type via the sense of smell is the link to biophysically constrained viral latency and all biodiversity.
There is no question that the passive-aggressive behavior of researchers like Johan Lundström is displayed as their failure to cite any of my published works.
See also: Smelling DNA with Joseph Orkin
Our ability to smell DNA arises only after the quantized energy-dependent creation of G protein-coupled receptors.
See also, from 1985: THE QUANTAL NATURE OF CONTROLLING STIMULUS-RESPONSE RELATIONS AS MEASURED IN TESTS OF STIMULUS GENERALIZATION
…the quantal interpretation, proposes that a stimulus-response relation functions as a unit that may or may not occur. From the latter viewpoint, the continuity typically obtained during generalization tests is deemed to be artifactual and to result from averaging across multiple controlling stimulus-response relations.
The “omnipresent adaptation to E2D” links multiple controlling stimulus-response relations from the energy-dependent de novo creation of G protein-coupled receptors to the foraging behavior of bacteria and to the physiology of pheromone-controlled human reproduction. Without the ability to sense differences in the fixation of amino acid substitutions in organized genomes DNA, biologically uninformed science idiots have no way to explain omnipresent pathology. Simply put, they have failed to link our choices to all pathology.
Clearly, serious scientists have linked the physiology of pheromone-controlled human reproduction from food energy to the ability to reproduce in all living genera. That is how the omnipresent pathology links the virus-driven degradation of messenger RNA from bacteria to the creation of archaea and L-forms. The L-forms are the last representation of what happens to all life forms that cannot find enough food energy to biophysically constrain viral latency.
See: Virus-mediated archaeal hecatomb in the deep seafloor
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
For comparison, see: A universal trend of amino acid gain and loss in protein evolution
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
Eugene Koonin knows that: “The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…”
That fact forces him to fight against the claims of adaptationists who have refuted his pseudoscientific nonsense about mutations and evolution.
See: Splendor and misery of adaptation, or the importance of neutral null for understanding evolution
Koonin thinks that serious scientists who have linked the creation of energy to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans must prove that everything the serious scientists know did not occur randomly after the sun’s anti-entropic virucidal energy emerged from nothing.
See for comparison:
VIDEO
“Light Unshackled” will be shown in its entirety during a special screening at 527 Forge Mill Road in Morganton, GA on Tuesday, October 24, at 6 p.m.
The game “Cytosis” is also already being distributed. Everyone over age 10 can learn to link the creation of anti-entropic virucidal light to all biophysically constrained biodiversity via what is known about the molecular mechanisms that link the physiology of pheromone-controlled reproduction to RNA-mediated viral latency.
No one I know expects you to understand the overwhelming complexity of the links from quantum physics to chemistry and molecular epigenetics to quantum souls. Many people I know expect you to be able to understand the claims about “Light Unshackled.”
2/4: Lighting a Flame – Light Unshackled – English
Episode 3 has been released, and Episode 4 will be released on October 27.
See: Light Unshackled Film
See also: Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy
In this study, across 60 melanoma cell lines, we find bimodal expression patterns of MHC-II, while MHC-I expression was ubiquitous. A unique subset of melanomas are capable of expressing MHC-II under basal or IFNγ-stimulated conditions. Using pathway analysis, we show that MHC-II(+) cell lines demonstrate signatures of ‘PD-1 signalling’, ‘allograft rejection’ and ‘T-cell receptor signalling’, among others.
UV light induced changes in the microRNA/messenger RNA balance have been linked to healthy longevity via the food energy-dependent RNA-mediated fixation of pheromone-controlled amino acid substitutions in organized genomes. Differences in the amino acid substitutions have been found in the organized genomes of all species.
The virus-driven theft of quantized energy such as UV light has been linked from the degradation of messenger RNA to all pathology.
See also: Medical Breakthroughs: Cancer
During clinical trials, the medication was famously used to treat former President Jimmy Carter , who two years ago announced he had cancer in his brain and liver and said his fate was “in the hands of God, whom I worship.” Four months later, his cancer was gone.
Was it God who caused the cancer, or did God cause its demise? From my perspective on light energy as information and energy-dependent RNA-mediated DNA repair, it is clear that melanoma-specific MHC-II expression represents a link from the virus-driven degradation of messenger RNA to a predicatable response from the innate immune system. That response has been made somewhat more predictable in the context of the phenotype that predicts the response to anti-PD-1/PD-L1 therapy.
See also: New Dancing Couple: PD-L1 and MicroRNA
MicroRNAs are regulatory molecules (~20 nt in length) with the ability to regulate the expression of genes. The recently described PD-1 and PD-L1 molecules have great importance for potential use in immunotherapy of many cancers. These molecules are associated with immune checkpoints and provide an opportunity for the treatment of advanced NSCLC patients with synthetic monoclonal antibodies. PD-L1 expression is strictly associated with microRNA function in lung cancer cells. The group of microRNAs related to PD-L1 includes, among others, miR-200, miR-197 or miRNA-34. Expression of these molecules may be useful in lung cancer diagnosis, qualification to anti-PD-1 or anti-PD-L1 antibody therapy and could be a potential therapeutic target. However, studies on PD-L1 -related microRNAs are necessary to develop advanced targeted molecular therapies.
Studies of studies on PD-L1 -related microRNAs and other microRNAs link the changes in electrons to ecosystems in all living genera. Focus on prevention and effective treatments of all pathology has been delayed by the focus on the CRISPR/Cas 9 gene editing technology. That focus is much more closely linked to the pseudoscientific nonsense touted by neo-Darwinian theorists who failed to link the virus-driven degradation of messenger RNA to all pathology.
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4 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (3)
3 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
The last RNA-mediated theory killer
< 1 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Exosomes, Inflammatory Disease, Pathogenesis, Treatment
< 1 MIN READ
0
Virus-driven energy theft: honeybee model
3 MIN READ
0
Antithetical conclusions (7)
3 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Energy-dependent RNA methylation (10)
4 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (4)
5 MIN READ
0
Virus-driven energy theft: definition?
5 MIN READ
0
The tipping point? 50, 000 publications (2)
2 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
MicroRNAs and/or QTLs: Who buried what?
2 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Genome-gate: Follow the money?
4 MIN READ
0
Creating and/or programming the immune system
< 1 MIN READ
0
Creating nutrient-dependent life with enough genes to survive
3 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Energy-dependent purpose vs teleophobic telorexia
12 MIN READ
0
Stress-linked population-level history dependence
5 MIN READ
0
Do not miss the misrepresentations
2 MIN READ
0
Energy dependent RNA-mediated immunity (5)
4 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
Science vs semantics
4 MIN READ
0
Bacteria see the light and they adapt (2)
5 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
0
Nutrient-dependent RNA-mediated cause and effect
3 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (7)
5 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
Will modern human populations adapt to the Zika virus?
5 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Cancer: Evolution 2.0’s Blind Spot
13 MIN READ
0
The unoffically uninvited
3 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
0
Stress-induced energy-dependent DNA repair
4 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Brain Atrophy Evolve?
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (5)
4 MIN READ
0
MicroRNAs vs Red Queen hypothesis
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Nutrient-dependent trophic analogs
3 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Cyclic cosmology and the stability of organized genomes
4 MIN READ
0
Unraveling the secrets of RNA-mediated events
2 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
FREE* SAMPLE: Histone modification
4 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs model
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Non-mainstream scientist shares Nobel prize in Medicine
3 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
Information and communication (2)
6 MIN READ
0
Information and communication
2 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Thermodynamic constraints did not evolve
3 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
The stability of organized genomes (2)
5 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Koonin: viruses killed neo-Darwinism
3 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
An unprecedented view of genomic complexity
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
Virus-driven death by evolutionary theory
3 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
RNA-mediated development
2 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
MicroRNAs and the exposome (2)
< 1 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Seeds of life: astrobiological theory and mutations theory
3 MIN READ
0
Pheromones and multicellularity
< 1 MIN READ
0
Is oxygen required for sensing nutrient chemicals and pheromones?
2 MIN READ
0
Pheromones: from microbes to man
< 1 MIN READ
0