Luis P. Villarreal has led the way towards discovery of the “origins of life.” He has helped to elucidate what is currently known about how the epigenetic landscape becomes the physical landscape of DNA in the organized genomes of species from microbes to humans.
Kudos to Suzan Mazur for admitting that she missed learning about his works. Perhaps a few neo-Darwinian evolutionary theorists will also admit they have missed something very important about the role of viruses in cell type differentiation because they were taught to believe in pseudoscientific nonsense about mutations, natural selection and the evolution of biodiversity.
I got the alert notice on this article after commenting about the role of viruses here: Researchers may have solved origin-of-life conundrum
They appear to be portraying the anti-entropic epigenetic effect of the sun’s biological energy and top-down causation that links light-induced amino acid substitutions to RNA-mediated cell type differentiation in all cell types of all plants and animals.
See for example Dobzhansky (1973) “Nothing in Biology Makes Any Sense Except in the Light of Evolution”
Excerpt: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla” (p. 127).
My comment: There seems to be no question that the biophysically constrained chemistry of RNA-mediated protein folding links the effect of light-induced amino acid substitutions to the anti-entropic creation of the first self-organized self-replicating plant cell. Does anyone know who decided that light-induced anti-entropic top-down causation should be placed into the context of the “big bang” cosmology industry and the evolution industry?
I think it might be wise to approach “origins of life” research starting from non-living viruses and entropic elasticity. That enables the link from the sun’s anti-entropic light energy to nutrient-dependent microRNAs via photosynthesis.
Starting with photosynthesis and the control of entropic elasticity linked to the energy-dependent nutrient-dependent control of viral microRNAs, serious scientists can get from mutations and physiopathology and compare ridiculous theories about beneficial mutations to the conserved molecular mechanisms of healthy metabolic networks and genetic networks via what is currently known about the physics, chemistry, and conserved molecular mechanisms of cell type differentiation.
Starting with “origin of life” on Earth paradoxes biologically uninformed pseudoscientists may get to simultaneous RNA-mediated hen and egg emergence (Pitkanen, 2015). But that has no explanatory power in the context of biologically-based cause and effect linked to the biological energy of the sun.
Excerpt: “There are actually relatively few formally-trained evolutionary scientists who will accept the virus-first perspective.”
My comment: That perspective changes everything. Viral microRNAs are linked to entropic elasticity. Nutrient-dependent microRNAs are linked from the anti-entropic epigenetic effect of light-induced amino acid substitutions to cell type differentiation in all genera.
The balance of viral microRNAs to nutrient-dependent microRNAs enables fixation of the amino acid substitutions via the biophysically constrained chemistry of protein folding and conserved molecular mechanisms of epigenesis and epistasis linked to biodiversity via everything currently known about physics, chemistry, and molecular biology.
Alternatively, “…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world. In this view of evolution there is no need of considering teleological elements.” –Nei (2013) Mutation-Driven Evolution
This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.