“Dead” nucleotides are biophysically constrained pH-dependent single nucleotide substitutions (SNPs).

See first: microRNA-mediated cures (4)

Remember what’s been known for decades about dead nucleotides, nucleotide substitutions that are biophysically constrained, when you read about the prevention of bioterrorism and public health fascism in

Imagination and remembrance: what role should historical epidemiology play in a world bewitched by mathematical modelling of COVID-19 and other epidemics? 6/7/21

…every established respiratory pandemic of the last 130 years has caused seasonal waves of infection and has culminated in viral endemicity.

Naturally attenuated viral endemicity is energy-dependent and microRNA-mediated via changes in the electron transport chain. Moving forward, see: Fumarate is a terminal electron acceptor in the mammalian electron transport chain 12/2/21

Fumarate reduction is likely important in diseases that cause tissue hypoxia such as ischemia, diabetes, obesity, and cancer. Cancer is an area of particular interest… it is also possible that the nutrient limitations in the tumor microenvironment, particularly those of glucose and aspartate (23, 24, 59), may limit de novo pyrimidine biosynthesis.

de novo pyrimidine biosynthesis is reported as: How some tissues can “breathe” without oxygen 12/2/21

…the electron transport chain, electrons are passed along in a sort of cellular relay race, allowing the cell to create ATP, the molecule that gives our cells energy to complete their vital functions.

For comparison to de novo pyrimidine biosynthesis in 1964, Bruce S. McEwen et al., presciently linked the ATP-dependent creation of RNA from oxidative phosphorylation to every aspect of biophysically constrained life on Earth via RNA interference (#RNAi).

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” 

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

ATP-dependent RNA interference (RNAi) has since been linked to the prevention of all virus-driven diseases via the patent for RNA-guided human genome engineering.

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition… (in which nearly identical copies can be problematic).

Elimination of problematic endogenous viral elements was placed into the context of God’s Creation of energy-as-information and the fact that Photosynthesis tunes quantum-mechanical mixing of electronic and vibrational states to steer exciton energy transfer 3/16/21, which was reported by young earth creationists as: Bacterial Proteins Use Quantum Mechanics 4/8/21

…we are actually seeing God actively exploit quantum effects in his purposeful construction of photosynthetic bacteria.

People who dismissed the claims of young earth creationists can now put them into the context of the fact that  MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and compare the facts to what is known about MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20

Support for young earth creationism came from former President Donald J. Trump on 4/23/20 when claimed that sunlight and humidity weaken coronaviruses. See: Trump touts study on sunlight to kill coronavirus

In A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America, Scott Atlas repeats the false claim that former President Donald J. Trump suggested people drink disinfectants to prevent or cure COVID19.

I am not the first to complain about the self-aggrandizing nonsense touted by Scott Atlas.

See:  A President Betrayed by Bureaucrats: Scott Atlas’s Masterpiece on the Covid Disaster 11/27/21

…Atlas inadvertently seems to perpetuate the distortion that Trump recommended ingesting bleach during a press conference.

Unless, they learn about microRNAs, what hope is there for the biologically uninformed masses and people like Scott Atlas, who have not been taught to link God’s Creation of energy-as-information from light-activated carbon fixation and microRNA biogenesis to peptide synthesis at the origin of life and naturally attenuated viral endemicity across kingdoms via fixation of amino acid substitutions in organized genomes?

The entire basis for public health fascism will someday be examined in context of how the genetically engineered SARS-CoV-2 was developed for population control via ineffective vaccines and the development of the synthetic mRNA vaccine that prevents naturally occurring light-activated carbon fixation from leading to energy-dependent DNA repair via femtosecond blasts of invisible UV light. Thank God if you live long enough to learn how to help the intelligent masses learn that A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission 2/3/07

See also: Endocrine Manifestations and New Developments in Mitochondrial Disease 10/13/21 for an update on Endocrine disorders in mitochondrial disease10/15/13

The update includes a section on the Background Nature of Mitochondrial Biology and Genetics that helps to link God’s Creation of energy as information from oxidative phosphorylation, fatty acid oxidation, the Krebs cycle, the urea cycle, gluconeogenesis, and ketogenesis to several other important cellular processes including thermogenesis, light-activated carbon fixation, fixation of amino acid substitutions that differentiate all cell types in all individuals of all species, and lipid metabolism, biosynthesis of haem and iron-sulphur clusters, calcium homeostasis, and apoptosis.

See:

Mitochondrial oxidative phosphorylation (OXPHOS) system and other pathways that are commonly implicated in mitochondrial diseases. The OXPHOS system comprises complexes I to V and 2 mobile electron carriers, CoQ10 and cytochrome c. The breakdown of carbohydrate (glycolysis) and fatty acids (beta oxidation) lead to the production of acetyl-coenzyme A (CoA), which is the first substrate of the TCA cycle (also known as the citric acid cycle or Krebs cycle). NADH and FADH2 are generated through a series of enzymatic reactions in which electrons are transferred along the mitochondrial respiratory chain (complex I-IV). High-energy electrons are passed along the complexes and protons (H+) are pumped out of the matrix space, creating an electrochemical membrane potential that is used by the ATP synthase (complex V) to phosphorylate ADP and generate ATP. The mtDNA encodes 13 protein subunits, 22 tRNAs and 2 rRNAs; there are multiple copies of mtDNA per cell, ranging from hundreds to thousands depending on the cell type. The replication, maintenance, transcription, and translation of mtDNA and mtDNA-encoded proteins are dependent on many nuclear-encoded proteins that are synthesized in the cytosol and imported into mitochondria through specific transporters (not shown). Genetic defects in nucleotide synthesis and salvage (eg, DGUOK, TYMP, TK2), mtDNA replication and maintenance (eg, catalytic subunit [POLG] and accessory units [POLG2] of polymerase gamma and TWNK), fusion and fission machinery (eg, MFN2, OPA1) can perturb mtDNA integrity and copy number, leading to the formation of multiple deletions and mtDNA depletion, respectively. This figure is derived from a previous published work (1).

Everything known to intelligent serious scientists about God’s Creation of the sense of smell in bacteria and patented microRNA-mediated treatments is linked to their conclusion without mentioning the fact that treatments are energy-dependent.

Conclusion

A potential role of pathogenic mitochondrial gene variants in endocrine disease was first recognized in 1992… The major endocrine manifestation of mitochondrial disease is diabetes mellitus…in patients with the m.3243A > G pathogenic variant. Other endocrine abnormalities are less common but include hypogonadism and infertility, adrenal insufficiency, and hypoparathyroidism.

Establishing a genetic diagnosis also has consequences in terms of transmission of the pathogenic variant to offspring. Recent developments in reproductive technologies means that, for families with mitochondrial disease, reproductive options are available.

See our comprehensive review of energy-dependent biophysically constrained micoRNA- / pre-mRNA-mediated cell type differentiation in species from microbes to humans:  From Fertilization to Adult Sexual Behavior (1996)

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