Pharmacogenomics: A road ahead for precision medicine in psychiatry 10/6/21

In this 2017 Precision Medicine Virtual Conference presentation, I linked the National Microbiome Initiative from microbial quorum sensing to the physiology of pheromone-regulated genetic processes of reproduction and endogenous RNA interference (#RNAi) via chromosomal rearrangements in flies from the works of Thomas Hunt Morgan (1910) to sympatric speciation across kingdoms.

The chromosomal rearrangements link light-activated carbon fixation to the ATP-dependent creation of RNA and fixation of amino acid substitutions links RNA interference (#RNAi) to the Precision Medicine Initiative via genome wide inferences of natural selection and facts about natural selection for energy-dependent codon optimality in the context of the pH-dependent physiology of reproduction.

I prefer to focus on facts rather than inferences. For example see: The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression 9/30/21

SARS-CoV-2 Nsp1 inhibits host mRNA translation and promotes mRNA decay

For comparison, natural selection for energy-dependent codon optimality establishes mRNA stability in the context of: Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21

…the availability of tRNAs and charged amino acids has been associated with translation efficiency and mRNA stability in vertebrates [12, 22, 24, 31, 56]. As such, it will be important to integrate tRNA profiles into our model predicting mRNA stability.

After linking fixation of charged amino acids to mRNA stability, who wants to focus on the facts about how pharmaceuticals and vaccines work, or why they do not work at the level of hydrogen-atom transfer in DNA base pairs in solution?

Obviously, there are researcher who do not want intelligent people to examine the “big picture” of how God’s Creation of sunlight and humidity biophysically constrain viral latency. The reseachers who obfuscate cause and effect may be working with atheist and Communists from China. See: Harvard’s Lieber Found Guilty

For comparison, Harvard’s George M. Church openly collaborates with the Chinese to show how light-activated pH-dependent naturally attenuated viral latency is linked to all energy-dependent biodiversity on Earth. See: Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency 2/8/21

Who are the good guys and who are the bad guys? 676 results from a search for “microRNAs and latency” link God’s energy-dependent regulation of the virus-driven lytic cycle and stress-linked reactivation of human endogenous retroviruses (HERVs) to healthy longevity or to virus-driven pathology via changes in single nucleotide polymorphisms (SNPs) in microRNAs.

Start tracking the footprints from Trump’s 4/23/20 claim about how sunlight and humidity weaken #COVID19 to the origin of life 5-10K years ago via Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20

Unless biologically uninformed science idiots can trace their claims about mutation-driven evolution back further than 5-10,000 years, they are stuck with the facts reported by intelligent serious scientists who have linked Fluorescence and ratiometric photoacoustic imaging of endogenous furin activity via peptide functionalized MoS(2) nanosheets to the fact that what is known about RNA interference links facts to the claim that “findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.” 11/28/12

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