A clear indicator of what is required to end the SARS-CoV-2 pandemic was published as: Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review) 12/20/21
The pathophysiology of coronavirus disease 2019 (COVID‑19) is mainly dependent on the underlying mechanisms that mediate the entry of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) into the host cells of the various human tissues/organs.
Ending the pathophysiology requires focus on biophysical constraints that prevent the entry of SARS‑CoV‑2 into the different cell types of various human tissues and organs. In some cases, intelligent serious scientists know how to stop entry and control microRNA-mediated replication cycles of viruses.
…these data demonstrate that platelet-derived miRNAs modulate solid tumor growth in vivo by broad-spectrum restructuring of the tumor cell transcriptome.
Experimentally established facts about energy-dependent changes in the microRNA-mediated complexity of viral‑host interactions link co‑localization of SARS‑CoV‑2 host cell entry mediators in different human tissues/organs to prevention or effective treatment of cancers and all other virus-driven pathology. That fact requires theorists to link quantum coherence to coherently organized biology.
Unfortunately, that is not what theorists do. Instead, they invent more theories, or they change existing theories.
I appeal to the masses: Help stop their nonsense. Learn how MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and learn about MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20
For instance, on 12/22/21, I discussed young earth creationism with someone who was beginning to understand the importance of linking UV light-induced fluorescence in microbes to claims about mutation-driven evolution in the context of soft tissue in fossilized bone.
That discussion, and the possibility of collaboration, prompted me to examine the cited works that link God’s Creation of sunlight and humidity from pH-dependent peptide synthesis at the origin of life to all biodiversity via the physiology of pheromone-regulated genetic processes of reproduction. The energy-dependent pheromone-regulated genetic processes have been detailed in species from cyanobacteria to humans via the energy-dependent Creation of the sense of smell.
The fact that Evolutionists Cannot Account for the Origin of the Sense of Smell can be compared to what I found.
Further studies of specific OR gene clusters in humans may identify the selected changes and shed light on what olfactory stimuli have exercised selective pressures on the human OR gene repertoire.
Selective pressures would only occur after the Creation of the sense of smell.
We find that simple changes in gene expression levels, plausibly driven by mutations in cis-regulatory elements, accumulate at similar rates in all three evolutionary lineages. What sharply distinguishes humans from other species is change in the timing and shape of developmental expression patterns.
The timing and shape of developmental expression patterns is microRNA-mediated/microRNA-driven. Thus, the energy-dependent Creation of microRNAs becomes the most important consideration as the basis for selective pressures.
Differences in DNA sequences correspond to nucleotide substitutions that have accumulated since their split from a most recent common ancestor (MRCA).
Link the revised timescale to light-activated changes in single nucleotide polymorphisms (SNPs) in microRNAs via this link from SNPs to the light-activated origin of life 5-10,000 years ago. See: Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20
Link the “footprints” to human-specific brain development via: Reduced purine biosynthesis in humans after their divergence from Neandertals 5/4/21
It is interesting that although ADSL is expressed and functions in all tissues, the down-regulation of purine biosynthesis in humans relative to apes, and in humanized mice relative to wild-type mice, is most pronounced in the brain. It is also interesting that mutations in humans that affect enzymes involved in purine metabolism have more pathological consequences in the nervous system than in other organs (Fumagalli et al., 2017; Micheli et al., 2011). Although no overt morphological or other brain-related phenotypes are observed in the mice humanized at pos. 428 and 429 (data not shown), it is thus possible that the A429V substitution in ADSL has contributed to human-specific changes in brain development and function. Future work will have to address this and other possibilities.
Despite clear links to facts about how light-activated microRNA biogenesis in marine bacteria and in soil bacteria plants has been linked from the pheromone-controlled genetic processes of reproduction in species from cyanobacteria to brain development in other primates and humans via A429V substitution in ADSL, the facts about olfaction and natural selection for food odors and pheromones were ignored when A high-resolution picture of kinship practices in an Early Neolithic tomb was published on 12/22/21
Results were reported as Ancient DNA reveals the world’s oldest family tree
The group lived about 5700 years ago.
The facts about the world’s oldest family trees and differences in primate brain development are consistent with this report: “Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants” (11/28/12).
The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.
The experimentally established facts are not consistent with the claims of human evolution across hundreds of thousands of years. See also: DNA methylation mediates the association between breastfeeding and early-life growth trajectories 12/22/21.
DNA methylation constrains energy-dependent RNA-mediated growth trajectories. We linked that fact from differentiation of cell types in species from microbes to humans in: From Fertilization to Adult Sexual Behavior (1996) See our section on molecular epigenetics.
It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. These sexually dimorphic patterns are labeled genomic or parental imprinting, and these imprintings are inheritable but non-genetic modifications of specific genes (Razin and Shemer, 1995; Reik, 1989; Surani, 1991; Zuccotti and Monk, 1995).
Ignoring the facts that link light-activated changes in SNPs in microRNAs to non-genetic modifications of specific genes exemplifies the epic failure of gene-centric theorists whose theories have not been linked to prevention or to effective treatment of virus-driven pathology via Peptide synthesis at the origin of life 11/13/20 and Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20