Yesterday, on the topic of vaccines used to prevent Ebola virus transmission, I wrote:

…. There is no such thing as an extinct virus. Their ability to steal energy is biophysically constrained until nutrient stress and/or social stress cause their reactivation.

I provided a link to The Darwin Code

Today, I read about The misleading evidence that fooled scientists for decades

After posting this comment to “The Conversation,” I learned I was blocked from posting anything to Facebook.

The misleading evidence that fooled some scientists for decades has never fooled serious scientists. Some have linked the creation of sunlight from the creation of microRNAs via links from photoluminescence to healthy longevity.  Simply put, serious scientists know that all life on Earth requires a source of anti-entropic energy (i.e., sunlight). See for example: Schrödinger (1944) What is Life?

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See for comparison:

Published on 30 Mar 2016

Poster: The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

See also: Energy as information and constrained endogenous RNA interference

Published on 15 Feb 2017

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes

See also: Raman Hyperspectroscopy Shows Promise for Diagnosis of Alzheimer’s

The method involves irradiating a sample with monochromatic light. This irradiation causes the molecules in the sample to vibrate, producing shifts in energy of the scattered photons.

The energy shifts result in a characteristic Raman spectrum, with individual peaks corresponding to a particular vibrational mode. All biochemical components of the sample contribute to the Raman spectrum proportionally to their concentration and inelastic light-scattering efficiency. With such detailed spectra produced, minute differences in composition can be illuminated when comparing two different samples, such as healthy and diseased tissue.

The light-activated endogenous substrates have been linked from differences in the energy of two photons to the proton motive force via the measurement of pH (the potential of hydrogen). In the context of pH, the differences in healthy or diseased tissue are perfectly clear. The technology will not be used only for the diagnosis of Alzheimer’s.

See for example: Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women 

Reported as: Cervical cancer may be driven by imbalance in vaginal bacteria, research finds

“High pH is a great reflection of the vaginal microbiome composition,” said Dr. Herbst-Kralovetz. “Lactobacilli produce lactic acid that directly lowers the pH. If you have high levels of lactobacilli you’re going to have a lower vaginal pH, and that’s associated with health.”

The anti-entropic virucidal energy of sunlight  has been linked from the creation of microRNAs to biophysically constrained viral latency and all biodiversity on Earth via changes in pH.  A lower pH, for example, links the proliferation of viruses in seawater to the destruction of coral reefs.  The viruses are found in bacteria, but pseudoscientists have ignored the facts that link the Virus-mediated archaeal hecatomb in the deep seafloor from virus-mediated changes in the pH of the vagina to neurodegenerative diseases such as Alzheimer’s.

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

In the context of light-activated endogenous substrates in all cell types of all living genera, the biologically uniformed science journalist, John Hewitt wrote: The vibrational theory of olfaction for the win October 31, 2017. He then proceeded to argue his case for neo-Darwinian pseudoscientific nonsense by putting “the win” back into the context of random mutations and natural selection. Then, he blocked me from seeing his Tweets so that I could not continue to comment on his moronic representations of what he claimed was:

“…an intrinsic covalently-bonded chromophore is spontaneously constructed from the side chains of the tripeptide Ser65-Tyr66-Gly67.”

Only biologically uninformed science idiots use terms like “intrinsic covalently-bonded” and “spontaneously constructed.” Natural selection for quantized energy-dependent codon optimality is the obvious link from biophysically constrained viral latency to fixation of amino acid substitutions in the organized genomes of all living genera.

But see: A universal trend of amino acid gain and loss in protein evolution

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

See for comparison:

From hydrogen atom transfer in DNA base pairs to ecosystems (video)

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on DNA base pairs in solution and RNA-mediated amino acid substitutions to chromosomal rearrangements via pheromone-controlled changes in the microRNA / messenger RNA balance. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent & pH-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Critical limits for enhanced medical care already include what is known about the RNA-mediated physics and chemistry of biologically-based ecological, social, neurogenic and socio-cognitive niche construction. The epigenetic landscape is clearly linked to the physical landscape of supercoiled DNA and top-down causation is manifested in increasing organismal complexity in species from microbes to humans. In all vertebrates and invertebrates the reciprocal relationships of species-typical nutrient-dependent & pH-dependent morphological and behavioral diversity are enabled by microRNAs, adhesion proteins, and pheromone-controlled reproduction. Ecological variation and biophysically constrained natural selection of nutrients cause the RNA-mediated behaviors that enable ecological adaptations, which include development of the brain during life history transitions. Ideas from population genetics typically exclude ecological factors, which must be linked to cell type differentiation. Theories are integrated with an experimental evidence-based approach that establishes what is currently known in the context of this mammalian model.

See also:

Upconversion nanocrystal ‘armoured’ silica fibres with superior photoluminescence for miRNA detection.

The regulation of survival and differentiation of neural stem cells by miR-124 via modulating PAX3.

MicroRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience.

miRNA editing landscape reveals miR-34c regulated spermatogenesis through structure and target change in pig and mouse.

The small non-coding RNA response to virus infection in the Leishmania vector Lutzomyia longipalpis.

Association of CD14 and macrophage migration inhibitory factor gene polymorphisms with inflammatory microRNAs expression levels in ankylosing spondylitis and polyarthralgia.

MicroRNA-221: biogenesis, function and signatures in human cancers.

Identification and Evaluation of Two Circulating microRNAs for Non-small Cell Lung Cancer Diagnosis.