From Fertilization to Adult Sexual Behavior (1996)

Excerpt: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…”

My comment: How far can this model of RNA-mediated cell type differentiation go? What links the model to ADHD? Could it be a single amino acid substitution (see below)? If so, can the response to ADHD pharmacotherapy be predicted by what is known about links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man? Are accurate representations of biologically-based cause and effect being ignored, except in presentations like this one?

Excerpt: Modern psychiatric drugs treat the chemistry of the whole brain, but neurobiologist David Anderson believes in a more nuanced view of how the brain functions. He illuminates new research that could lead to targeted psychiatric medications — that work better and avoid side effects. How’s he doing it? For a start, by making a bunch of fruit flies angry. (Filmed at TEDxCaltech.)

“If specific brain functions collapse as a result of irregular dopamine levels, researchers theorize, attention deficit hyperactivity disorder (ADHD), depression, or even schizophrenia may be the result.

My comments: What if that theory had been supported by experimental evidence of biologically-based cause and effect in organism from microbes to man beginning with what was known in 1996 about cell type differentiation. Could the link from RNA-mediated events to amino acid substitutions and cell type differentiation be important to consider in the context of epigenetic links to morphological and behavioral phenotypes? Of course!

There is only one way to link the epigenetic landscape to the physical landscape of DNA in the organized genomes of all species from microbes to nematodes to flies to other mammals and to humans. It is via nutrient-dependent amino acid substitutions.

See, for example: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Excerpt: Its function is known to be affected by a functional single nucleotide polymorphism (SNP) in COMT (G-to-A base-pair substitution) leading to a methionine (Met) valine (Val) substitution at codons 108/158 (COMT Val158Met). Carriers of the Met allele have been found to display a fourfold decrease in enzymatic activity compared to Val allele carriers going along with an increase of prefrontal DA activity (Lachman et al. 1996; Lotta et al. 1995).

The methionine (Met) valine (Val) substitution is the amino acid substitution that epigenetically links nutrient-uptake to the metabolism of nutrients and the epigenetic effects of metabolism to the pheromone-controlled physiology of reproduction. That means a single amino acid substitution links morphological and behavioral diversity from ecological variation in nutrient availability to the physiology of human behavior.

When atypical behaviors associated with ADHD are manifested, pharmacotherapy can be started immediately, or testing can be performed to determine which medication may be most effective / least detrimental. Was your child tested? Is your child a mutant? Evolutionary theorists continue to suppress accurate information about biologically-based cause and effect by presenting us all with their pseudoscientific nonsense about beneficial mutations that somehow lead to the evolution of biodiversity. You now have a choice. Believe in that nonsense, or find out how testing for variations that link genetic networks to metabolic networks may benefit you and your loved ones.

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