See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18
Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications that mention microRNAs. Stop ignoring the facts from DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition 9/5/21
The bispecific intracellular miRNA controllable DNA circuit…easily extends to various cell type discrimination by adjusting the [energy-dependent Creation of] miRNA species…
The facts eliminate stupid theories. Eliminating them…
…provides huge opportunities for accurately differentiating multiple cell types at the molecular level.
The authors linked energy-dependent changes in SNPs in microRNAs to biophysically constrained viral latency. That fact links virus-driven energy theft from the degradation of mRNA to all virus-driven pathology (from SARS-CoV-2 to cancers).
See for reviews of how SNPs in microRNAs are linked to healthy longevity or to virus-driven diseases.
Genome-Wide Analysis of MicroRNA-related Single Nucleotide Polymorphisms (SNPs) in Mouse Genome” 4/1/20 and Role of SNPs in the Biogenesis of Mature miRNAs 6/18/21
See also: miR-155 T/A (rs767649) and miR-146a A/G (rs57095329) single nucleotide polymorphisms as risk factors for chronic hepatitis B virus infection among Egyptian patients 8/26/21 and Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review 8/28/21
If you still believe in stupid theories about beneficial mutations and evolution across billions to millions of years, see Role of miRNA and lncRNAs in organ fibrosis and aging (9/1/21) and Nucleoporins’ exclusive amino acid sequence features regulate their transient interaction with and selectivity of cargo complexes in the nuclear pore 9/2/21
For a historical perspective on food energy-dependent pheromone-regulated genetic processes of reproduction and biophysically constrained biodiversity see: Genetic Crossroads: The Middle East and the Science of Human Heredity (2021)
It links the history of light-activated carbon fixation from Peptide synthesis at the origin of life 11/13/20 to microRNA-mediated pH-dependent viral latency via protonated RNA interference (RNAi) and Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2 9/2/21
The mouse to human model of light-activated carbon fixation, nutrient-dependent pheromone-regulated genetic processes, fixation of amino acid substitutions and ecological adaptations was published as: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18
The companion papers [159,160] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.
The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.
See for comparison:
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7], and the last few years have seen considerable progress in our understanding of their genetic basis.
“It is still not clear how elevated cryptic transcription contributes to aging, but the evidence is accumulating that it is detrimental to mammals as it is for yeast and worms,”