microRNA 130,014 results

The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19 (4/28/20) and other virus-driven diseases was published less than one week after former President Trump clearly stated that sunlight and humidity kill coronaviruses.

See also: Imagination and remembrance: what role should historical epidemiology play in a world bewitched by mathematical modelling of COVID-19 and other epidemics? 6/7/21

…every established respiratory pandemic of the last 130 years has caused seasonal waves of infection and has culminated in viral endemicity.

Remember, one of the world’s leading experts on stress, Bruce S. McEwen et al., (1964) linked God’s Creation of sunlight and humidity to biophysically constrained viral endemicity (viral latency) across kingdoms via oxidative phosphorylation and the pH-dependent physiology of pheromone-regulated genetic processes

In the same year, Dobzhansky (1964) linked substitution of one amino acid, valine in place of glutamic acid in the beta chain of the hemoglobin molecule to sympatric speciation in primates and established the claim that molecular biologists / good men, like McEwen, are serious scientists.

For comparison, Feynman claimed that theoretical physicists exemplify human idiocy. See: Richard Feynman on units of energy (video). That claim can be linked to his claim that social scientists are pseudoscientists (video).

Pseudoscientists, who failed to link the virus-driven degradation of messenger RNA to all diseases via changes in fixation of energy-dependent amino acid substitutions, followed a course that led to the APA’s apology for supporting racism 10/29/21

The APA apology could have been based on something as critical to the understanding of racism as the Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups 9/19/21 via this claim from Bruce S. McEwen et al., (1964):

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The main difference between thymus and thyroid is that thymus is mainly involved in the development and differentiation of T cells whereas thyroid is mainly involved in the secretion of thyroxine and triiodothyronine, which govern the metabolism

That links the ATP-dependent Creation of RNA from single nucleotide polymorphisms in microRNAs to pH-dependent diversity of all cell types in all tissues of all species via what is known about how RNA interference governs metabolism linked to the food energy-dependent creation of the immune system.

See the patent for light-activated carbon fixation and biophysically constrained RNA interference (RNAi):

RNA-Guided Human Genome Engineering 

In the context of biophysically constrained RNAi, it is long past time to reconsider the claims from Return of the Lost Evolutionary Psychology Interviews and Who Are Psychology’s Geniuses? Part 2”  (2016)

I don’t think it is too grand a claim to say that this group of researchers has radically changed how literate people now think about human nature.

I’ve never met a psychologist who I thought was an intelligent serious scientist. However, each of the scientifically illiterate researchers I met changed how some literate people think about human nature. But most of those people are equally scientifically illiterate.

Scientific literacy requires the ability to link physics, chemistry, and biology to energy-dependent links from quantum coherence to coherently organized biology via biophysically constrained viral latency.

See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20

…naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.

That fact links scientific literacy to other facts that led to the APA’s apology and the claims in this 2018 review of nutritional epigenetics.

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems  4/18/18  One amino acid substitution, EDAR V370A was linked to ecological adaptations across kingdoms via the laws of physics, the basic principles of chemistry, and the biologically based physiology of reproduction. See: “Kohl’s Laws of Biology”

All pseudoscientists who study race and/or “gender” may be forced to apologize for failing to link “Kohl’s Laws of Biology” from Ben Feringa’s 2018 claims to scientific progress and the cure for all virus-driven diseases via the claim that “2013 was the year in which prophesy from the bible became reality.” (video)

For a historical perspective on how God’s Creation of sunlight and humidity were linked to prevention of all virus-driven diseases from COVID-19 to cancer, see: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination 11/5/13

We found that miR-200/ZEB forms a tristable circuit that acts as a ternary switch, driven by miR-34/SNAIL, that is a monostable module that acts as a noise-buffering integrator of internal and external signals.

For a recent update, see: The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells 11/3/21

Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates motility and invasion.

That fact was placed into this context:

ZEB1 drives turnover of the MET receptor tyrosine kinase by hastening receptor endocytosis and transport to the lysosomal compartment for degradation. ZEB1 relieves a plus-end-directed microtubule-dependent kinesin motor protein (KIF13A) and a clathrin-associated adaptor protein complex subunit (AP1S2) from microRNA-dependent silencing, thereby accelerating cargo transport through the endocytic recycling and retrograde vesicular pathways, respectively. Depletion of KIF13A or AP1S2 mitigates ZEB1-dependent focal adhesion dynamics, front-rear axis polarization, and cancer cell motility. Thus, ZEB1-dependent transcriptional networks govern vesicular trafficking dynamics to effect cell polarity change.

The challenge for intelligent serious scientists is to explain energy-dependent cell type differentiation to scientifically illiterate psychologists  and to other pseudoscientists who know nothing about naturally attenuated viral endemicity. Most psychologists believe in stupid theories about the emergence of energy from the cosmic void and the evolution of humans from pond scum during the past billions to millions of years.

Most will not look at the experimental evidence detailed in more than 130,000 indexed published works that mention microRNAs. You and your children and/or grandchildren may suffer unnecessarily and die prematurely for that reason.

See: What you need to know about the coronavirus vaccine for kids ages 5 to 11 10/29/21

You should know that “…every established respiratory pandemic of the last 130 years has caused seasonal waves of infection and has culminated in viral endemicity.”

Injections of synthetic mRNA may stop the viral endemicity and be used for population control.

See also:  Footprints of Multiple Interspecies Re-assortment Events

Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed.

The effect of synthetic mRNA vaccines on fertility and behavior has been reported as the biggest threat to humanity there has ever been. To view the magnitude of the threat, see: From Fertilization to Adult Sexual Behavior (1996). Every aspect is energy-dependent and  microRNA-mediated in all species. Note, however, in 1996, microRNAs were referred to as pre-messenger RNAs (pre-mRNAs). Still, everyone knew that no matter what they were called, they did not automagically create themselves. For fun, ask a theorist where they came from.

Keep Reading