See first: Naturally attenuated viral endemicity (7)

MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly 11/19/21

…we describe a new role for miR-101-3p as a modulator of mitochondrial metabolism via its regulation of multiple mitochondrial processes, including mtDNA transcription and complex II biogenesis.”

See also: Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function 11/24/21

Exposure to long wavelength light (650–900 nm) in animals improves mitochondrial function, increasing ATP production and reducing ROS8,9.

More than 131,000 indexed publications mention microRNAs. By the time you read this, light-activated microRNA-mediated regulation of complex II biogenesis will again have been linked from the ATP-dependent Creation of RNA and multiple mitochondrial processes to reduced ROS via oxidative phosphorylation and epigenetic effects on mitochondrial DNA transcription.

Intelligent serious scientists know that the microRNA-mediated epigenetic effects of light extend across kingdoms and across the space-time continuum via: Perspectives and challenges of epigenetic determinants of childhood obesity: A systematic review 11/23/21.

…evidence suggestive of an association with childhood obesity for DNA methylation of specific genes and microRNAs (miRNAs).

The facts links our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996) to the transgenerational epigenetic inheritance of all biophysically constrained morphological and behavioral phenotypes across kingdoms via pre-mRNAs, which are now also called microRNAs.

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

Indeed, intelligent serious scientists start with light-activated energy-dependent changes in microRNA-mediated plant life and link them to sexual orientation from yeasts to humans. That scares all theorists. See; Genome-Wide Analysis of Alternative Splicing and Non-Coding RNAs Reveal Complicated Transcriptional Regulation in Cannabis sativa L 11/5/21

…results provided insights into the complicated network of gene expression and regulation in C. sativa.

Growth of C. sativa, and other plants, requires light-activated carbon fixation of endogenous substrates in the context of humidity and pH-dependent biophysically viral latency.

Links from  Analysis of microRNA expression profile in Emiliania huxleyi in response to virus infection are perfectly clear in the context of Rosalind Franklin’s work with the tobacco mosaic virus and what is known about the functional structure and the diversity of supercoiled DNA.

See:  Structural diversity of supercoiled DNA 10/12/15

By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism.

These authors hinted at the virus-driven cause of negative supercoiling via polite ridicule of theorists who appear to know nothing about it. See:

 

Reminder (circle-back): “MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly 11/19/21

See also:  Integrated Analysis of Mutations, miRNA and mRNA Expression in Glioblastoma 11/16/21 and link microRNA-mediated mitochondrial metabolism to healthy longevity via biophysical constraints on the death gene.

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11

If you do not want to know anything about how to prevent unnecessary suffering and premature death, ignore what is known about light-activated carbon fixation and naturally attenuated biophysically constrained viral latency, which was detailed in this patent:  RNA-Guided Human Genome Engineering for what McEwen et al. detailed in 1964.  Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

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