See first: Orchestrated death of Jews et al., by Egyptians (1)

Summary: Given the overwhelming amount of scientific progress made toward eliminating all virus-driven pathology via changes in diet and/or microRNA-mediated treatments, EL-Sayed Mahgoub‘s theft of intellectual property is not funny.

He has been parroting my claims for several months without linking to the sources for his information. This presents a threat to Homeland Security via acts linked from his support for stupid gene-centric theories to crimes against humanity. The crimes against humanity typically fail to link God’s Creation of energy-as-information from single nucleotide polymorphisms (SNPs) in microRNAs to biophysically constrained viral latency and healthy longevity via the physiology of reproduction.

For example, I reported these three things based on a conversation with friends who have worked with Homeland Security.

1) CCR5 Targeted Cell Therapy for HIV and Prevention of Viral Escape

2) Jon Stewart interviews Greg Bear 6/1/07

3) A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission

I was about to follow up when EL-Sayed Mahgoub blocked me from seeing his posts. I suspect he will continue to steal the content when I post on: The CCR5-Delta32 Genetic Polymorphism and HIV-1 Infection Susceptibility: a Meta-analysis and CCR5Delta32 deletion as a protective factor in Czech first-wave COVID-19 subjects.

The CCR5-Delta32 polymorphism may predict the severity of SARS-CoV-2 and HIV infection. That claim can be linked from an attempt to create a HIV vaccine to the genetic engineering of SARS-CoV-2 in the Wuhan lab and attempts to create an effective vaccine for coronaviruses.

The vaccines may be unnecessary because coronaviruses are weakened by sunlight and humidity — as stated clearly by former President Trump on 4/23/20. Sunlight and humidity biophysically constrain the effects of the environment on microRNA biogenesis, and downstream effects on cell type differentiation across kingdoms from microbes to humans.

I fell behind as newer articles were published and/or indexed, but I will now continue to list articles that were indexed on PubMed on 10/25/21 It will become obvious that spurious claims about being “the first” to link some aspect of microRNA-mediated biophysically constrained viral latency across kingdoms will continue to be made by those who have missed everything known to intelligent serious scientists for ~130 years.

…miRNAs have been shown to be highly specific and sensitive to the clinical condition being studied.

Regulation of autophagy by miRNAs in human diseases

…in some of these reports, the miRNAs do not solely regulate autophagy but also the crosstalk between autophagy and other cell death pathways (apoptosis) and stress (ER stress) pathways. This finding further expands the scope of miRNA-based targeted therapy beyond the realms of autophagy in these models. Finally, it is encouraging that certain traditional medicines and small molecule drugs are reported to employ the miRNA-autophagy network in some of the disease models.

Small molecules with huge impacts: the role of miRNA-regulated PI3K pathway in human malignancies

…a considerable number of signaling cascades have evolved within cells to meet their multifaceted needs.

It is foolish to link anything except food energy-dependent pheromone-regulated genetic processes of reproduction to “…the regulatory role of these small non-coding RNAs on the PI3K/Akt/mTOR signaling axis in carcinogenesis.”

Epigenetics of Immunoglobulin G Glycosylation

…the expression of many glycosyltransferases is regulated by DNA methylation and by microRNA (miRNA) molecules, but the involvement of other epigenetic mechanisms, such as histone modifications, in the regulation of glycosylation-related genes (glycogenes) is still poorly understood.

Glycosylation cannot be understood by fools who place DNA methylation before energy-dependent microRNA-mediated RNA interference (RNAi)

MicroRNAs in the Onset of Schizophrenia

…we examine how hemizygosity for DGCR8, which encodes an obligate component of the complex that synthesizes miRNA precursors, may contribute to the onset of psychosis in patients with 22q11.2 microdeletions and how animal models of this disorder can help us understand the many roles of miRNAs in the onset of schizophrenia.

The virus-driven degradation of messenger RNA has been linked to schizophrenia, suicides and mass murders via changes in one amino acid substitution: See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

See also: Uncovering the Roles of MicroRNAs in Major Depressive Disorder: From Candidate Diagnostic Biomarkers to Treatment Response Indicators

…we critically and systematically reviewed herein the studies assessing the potential biomarker role of several candidate miRs for MDD, as well as treatment response monitoring indicators, in order to enrich the current knowledge and facilitate possible diagnostic biomarker development…

Role of microRNAs in Disorders of Gut-Brain Interactions: Clinical Insights and Therapeutic Alternatives

Studies have shown miRNAs regulate gut functions such as visceral sensation, gut immune response, GI barrier function, enteric neuronal development, and GI motility. These biological processes are highly relevant to the gut where neuroimmune interactions are key contributors in controlling gut homeostasis and functional defects lead to DGBIs.

Noncoding-RNA-Mediated Regulation in Response to Macronutrient Stress in Plants

…we highlight the recent findings of ncRNA-mediated regulation in response to macronutrient stress, with special emphasis on the large-scale sequencing efforts for screening out candidate nutrient-responsive ncRNAs in plants, and discuss potential improvements in theoretical study to provide better guidance for crop breeding practices.

Epstein-Barr Virus miR-BART1-3p Regulates the miR-17-92 Cluster by Targeting E2F3

Our results suggest a possible role of miR-BART1-3p in cell cycle regulation and in regulation of the miR-17-92 cluster through E2F3 suppression.

Identifying Complex lncRNA/Pseudogene-miRNA-mRNA Crosstalk in Hormone-Dependent Cancers

This study is the first to investigate pseudogene-associated ceRNAs across a group of related cancers and highlights the value of this approach to understanding the shared molecular pathogenesis in a group of related diseases.

Virus-Induced Tumorigenesis and IFN System

This review aims to collect recent studies on the complex relationship between the host innate response to oncogenic viruses (i.e., HPV, HTLV-1, MCPyV, JCPyV, Herpesviruses, HBV, HCV) and tumorigenic processes by focusing mainly on regulatory crosstalks between viral components and the type I IFN system. It is a picture of new mechanisms by which type I IFNs may be affected and, in turn, affect signaling pathways to mediate anti-proliferative and antiviral responses in virus-induced tumorigenic context. Studies on cellular and viral miRNAs machinery, as well as cellular communication and microenvironment modification via classical secretion mechanisms and extracellular vesicle-mediated delivery are described.

Home and Away: The Role of Non-Coding RNA in Intracellular and Intercellular DNA Damage Response

Non-coding RNA (ncRNA) has recently emerged as a vital component of the DNA damage response (DDR), which was previously believed to be solely regulated by proteins. Many species of ncRNA can directly or indirectly influence DDR and enhance DNA repair, particularly in response to double-strand DNA breaks, which may hold therapeutic potential in the context of cancer.

Footprints of microRNAs in Cancer Biology

The mechanisms by which miRNA exerts its cancer-promoting or inhibitory effects are apparent through the various cancer hallmarks, which include selective proliferative advantage, altered stress response, vascularization, invasion and metastasis, metabolic rewiring, the tumor microenvironment and immune modulation; therefore, this review aims to highlight the association between miRNAs and the various cancer hallmarks by dissecting the mechanisms of miRNA regulation in each hallmark separately.

Small Extracellular Vesicle-Derived microRNAs Stratify Prostate Cancer Patients According to Gleason Score, Race and Associate with Survival of African American and Caucasian Men

…we identified novel sEV-associated miRs that can differentiate PCa patients from normal, AA from CA and high from low GS and predicts RFS.

MicroRNAs and Metabolism: Revisiting the Warburg Effect with Emphasis on Epigenetic Background and Clinical Applications

A better understanding of reversible epigenetic and metabolic alterations opened up new horizons in the personalized treatment of cancer. MicroRNA expression levels can be utilized in differential diagnosis, prognosis stratification and prediction of chemoresistance. The therapeutic modulation of microRNA levels is an area of particular interest that provides a promising tool for restoring altered metabolism of cancer cells.

Dysregulation of miRNAs in DLBCL: Causative Factor for Pathogenesis, Diagnosis and Prognosis

…miRNAs play an essential role in the pathogenesis of numerous diseases, including diabetes, cardiovascular diseases, viral diseases and cancer. Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin’s lymphoma (NHL), arising from different stages of B-cell differentiation whose pathogenesis involves miRNAs. Various viral and non-viral vectors are used as a delivery vehicle for introducing specific miRNA inside the cell.

MMV-db: vaccinomics and RNA-based therapeutics database for infectious hemorrhagic fever-causing mammarenaviruses

The database integrates vaccinomics and RNA-based therapeutics data for seven human pathogenic MMVs associated with severe viral hemorrhagic fever and lethality in humans. Protein-specific cytotoxic T lymphocytes, B lymphocytes, helper T-cell and interferon-inducing epitopes were mapped using a cluster of immune-omics-based algorithms and tools for the seven human pathogenic viral species. Furthermore, the physiochemical and antigenic properties were also explored to guide protein-specific multi-epitope subunit vaccine for each species. Moreover, highly efficacious RNAs (small Interfering RNA (siRNA), microRNA and single guide RNA (sgRNA)) after extensive genome-based analysis with therapeutic relevance were explored.

Stress-induced miRNAs isolated from wheat have a unique therapeutic potential in ultraviolet-stressed human keratinocyte cells

…stress-induced wheat miRNAs produced using a biofactory approach have strong potential as a novel and effective alternative therapy for UV stress-related skin damage.

Genetic polymorphisms in the miR-372 (rs12983273) and LncRNA HULC (rs7763881) genes and susceptibility to Hepatitis B virus (HBV) infection

To the best of our knowledge, the present study was the first to investigate the relevance of miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) gene polymorphisms to the risk of HBV infection in the Egyptian population.

miRNA profile and disease severity in patients with sickle cell anemia

…low levels of miR510 and miR629 expression are associated with greater SCA disease severity. Further studies are still necessary to elucidate mechanism of these miRNAs and their related proteins.

See also: Naturally attenuated viral endemicity (1) in prep.

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