1) On the Origins of Life

The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in all vertebrates.

The role of food odors and hormone-controlled cell type differentiation in all vertebrates also links changes in the balance of viral microRNAs and nutrient-dependent microRNAs to the physiology of their pheromone-controlled reproduction via GnRH and feedback loops linked to chromatin loops. See: Feedback loops link odor and pheromone signaling with reproduction and A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping, which was reported as: 3-D maps of folded genome: Catalog of 10,000 loops reveals new form of genetic regulation

Excerpt: “More and more, we’re realizing that folding is regulation,” said study co-first author Suhas Rao, a researcher at Baylor’s Center for Genome Architecture and a 2012 graduate of Harvard College. “When you see genes turn on or off, what lies behind that is a change in folding. It’s a different way of thinking about how cells work.”

2) Biologists identify brain tumor weakness

Excerpt 1)  “Without GLDC, glycine enters a different metabolic pathway that generates toxic products that accumulate and kill the cell.”

My comment: They linked glycine and one enzyme from nutrient-dependent pheromone-controlled metabolic networks to genetic networks in all vertebrates via the conserved molecular mechanisms of epigenetically-effected RNA-mediated amino acid substitutions and cell type differentiation.

3) Beyond Genetic Evolution. A Conversation With Eva Jablonka

Excerpt 1) “There was no molecular mechanism to describe the developmental effects…”

Excerpt 2) “An important epigenetic inheritance mechanisms, that was fully characterize only after 1998 and is now being investigated very intensely, is the one that is mediated by small RNAs.”

Excerpt 3) “DNA is not just a very stable molecule. In fact it is not very stable at all. It requires all the machinery of the cell to make it stable, to edit away and to get rid of mistakes.”

My comment: David M. Sabatini’s group appears to have just linked “Nutrient-Sensing Mechanisms across Evolution” from the light-induced de novo creation of amino acids to the RNA-mediated stability of all organized vertebrate genomes via insertion of glycine in the GnRH decapetide. See “SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

The link from the de novo creation of amino acids and cell type differentiation also appears to link viruses and entropic elasticity to mutations and physiopathology. However, top-down causation links the anti-entropic energy of the sun to RNA-mediated amino acid substitutions and cell type differentiation in all individuals of all genera via the conserved molecular mechanisms of biophysically constrained RNA-mediated protein folding.

Fixation of the amino acid substitutions in the organized genomes of all genera occurs via the physiology of reproduction, which links ecological variation to ecological adaptation without using or re-defining the term “evolution.”  All biodiversity is nutrient-dependent and in species from microbes to man the metabolism of nutrients is linked to the pheromone-controlled physiology of reproduction. The role of viruses is becoming clearer at the same time evolutionists seem to be avoiding links from perturbed protein folding to pathology because amino acid substitutions are clearly linked to biodiversity, which is exemplified as ecological adaptation.

 

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