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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Behavior: The first response is RNA-mediated not genetically-determined

Diana Maria Petrosanu asked a question in an Evolutionary Psychology News discussion about Evolution’s Random Paths Lead to One Place. I’ve been very vocal in other discussions that tout ridiculous theories that have been repeatedly refuted by biological facts. My answer to her question might help others to understand the language of RNA-mediated events. That’s why I added details to my representation at Combating Evolution to Fight Disease.  Whether or not the addition to my comments is published or understood…

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Mechanisms that are not understood increase clarity

Science 12 September 2014: Vol. 345 no. 6202 pp. 1240-1241 DOI: 10.1126/science.1252966 Perspective RNA Function RNA and dynamic nuclear organization John Rinn1,2,3, Mitchell Guttman4 Excerpt: “While the mechanism for how lncRNAs establish these domains is not fully understood, it is becoming increasingly clear that lncRNAs are important at all levels of nuclear organization—exploiting, driving, and maintaining nuclear compartmentalization.” My comment to Science Magazine: Title: RNA and dynamic nuclear organization Received: Fri, 12 Sep 2014 03:12:03 -0400 Your Comment: The authors…

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Pattern recognition and conserved receptors (TAARs)

Olfactory Receptor Patterning in a Higher Primate Excerpt: We found that TAARs are also expressed in the macaque OE, suggesting that these receptors may also function as chemosensory receptors in the human nose. My comment: The article links the senior author’s prior works from nutrient-dependent RNA-mediated events and the de novo Creation of odorant receptor (OR) genes to her 2005 co-authored work on the hormone-organized control of these RNA-mediated events: Feedback loops link odor and pheromone signaling with reproduction. Excerpt:”At…

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Nutrient-dependent erythropoiesis and anemia

A critical role for mTORC1 in erythropoiesis and anemia Excerpt 1): “Cells must coordinate their rate of growth and proliferation with the availability of nutrients. mTOR , a serine-threonine kinase, is one the key proteins responsible for nutrient signaling in eukaryotic cells. mTOR is activated by conditions that signal energy abundance, such as the availability of amino acids, growth factors, and intracellular ATP. Activated mTOR then phosphorylates a set of downstream targets that promote anabolic processes, such as protein translation…

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Evolutionary heritage or ecological adaptation? Racism versus reality

Jewish Heritage Written in DNA Fully sequenced genomes of more than 100 Ashkenazi people clarify the group’s history and provide a reference for researchers and physicians trying to pinpoint disease-associated genes. By Kate Yandell | September 9, 2014 Excerpt: These results are compatible with those of prior work on mitochondrial DNA (mtDNA), which is passed on maternally. This prior work suggested that Ashkenazi men from the Middle East intermarried with local European women. The Ashkenazi population “hasn’t been likely as…

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A relatively young branch of science called epigenetics

Epigenetics: genes, environment and the generation game New research claims that environmental factors affect not just an individual’s genes but those of their offspring too. Diabetes, obesity – even certain phobias – may all be influenced by the behaviour of our forebears by Angela Saini, The Observer, Saturday 6 September 2014 Excerpt 1): “…she was kept on a near-starvation diet when she was close to giving birth.” Excerpt 2: with my emphasis): This puzzling study, published last month, echoes many…

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Insect homology and diversity attributed to mutations

Ancient homology underlies adaptive mimetic diversity across butterflies Excerpt: “Surprisingly, our results suggest that modulation of this conserved developmental gene has occurred in tandem between these two deeply divergent butterfly lineages, implying an unexpected and remarkable level of predictability in the evolutionary process.” Reported as: A single evolutionary road may lead to Rome Excerpt: “Copying errors and genomic viruses directly lead to the wing patterns of these beautiful butterflies,” Gallant said. “It’s these accidents that allow the evolutionary process to…

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Biophysically constrained beginnings of RNA and DNA

Any anonymous participant in the discussion of: DNA may have had humble beginnings as nutrient carrier (Sep 01, 2014 by Adam Hadhazy) asks: “when are you going to keep quiet?” In a series of responses, I have explained the problem I have with honoring his request. The following excerpts from Wikipedia and other sources are loosely strung together because there is no point to providing more extensive details of biologically-based cause and effect until others accept the fact that mutations…

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Baby talk: More misrepresentations of ecological adaptations

Evolution’s Baby Steps by Carl Zimmer Excerpt 1) “When organisms find themselves in a new environment, they develop in a way that helps them cope with their new surroundings. Their descendants may acquire mutations that encode that anatomy in their genes. Eventually evolution takes them beyond where plasticity alone could take them.” My comment: It’s time for science journalists to stop touting this nonsense (above). Ecological variation leads from nutrient uptake in new environments to RNA-mediated amino acid substitutions. If…

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Comparing divergent model organisms

Comparative analysis of the transcriptome across distant species Excerpt: Overall, our results underscore the importance of comparing divergent model organisms to human to highlight conserved biological principles (and disentangle them from lineage-specific adaptations). My comment: In the detailed comparisons of divergent model organisms portrayed in Nutrient-dependent/pheromone-controlled adaptive evolution: a model, I underscored what is known about cell type differentiation in species from microbes to man. By placing what is known into the context of nutrient-dependent amino acid substitutions and biodiversity…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]