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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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RNA-mediated species diversification from microbes to primates

Mycobacteriophage-drived diversification of Mycobacterium abscessus Biology Direct (15 September 2014) OPEN ACCESS Excerpt (with my emphasis): “Widespread occurrence of phage sequences in almost all studied M. abscessus complex isolates suggests that the rate of prophage invasion is faster than the rate of mutation, implying rapid evolution of M. abscessus.” My comment: The faster rate of prophase invasion suggests ecological adaptations occur more rapidly than evolution. That may be why no experimental evidence of biologically-based cause and effect suggests that evolution…

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RNA-mediated events found everywhere

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA Related articles Related blog posts on this site Reported as Scientists discover RNA modifications in some unexpected places Excerpt 1): “…there are multiple types of RNA, three of which—messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA)—are essential for proper protein production. Moreover, RNAs that are synthesized during the process known as transcription often undergo subsequent changes, which are referred to as “post-transcriptional modifications.” My comment: These microRNA/messenger RNA-mediated…

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Reseachers think copy number variation is genetically determined

Researchers develop new type of genetic test for identifying developmental disorders Excerpt: “…the team sought to find specific genes responsible for certain development disorders, and they appear to have done just that.” My comment: The genes cannot be responsible for any developmental disorders because morphological and behavioral phenotypes arise in the context of RNA-mediated events that differentiate cell types via amino acid substitutions. See also: Genotype, observed phenotype, and distinctly disordered behaviors Genetically distinct behavioral disorders are RNA-mediated just like…

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Some neuroscientists think a mutation led to human language development

Neuroscientists identify key role of language gene Excerpt: “Neuroscientists have found that a gene mutation that arose more than half a million years ago may be key to humans’ unique ability to produce and understand speech.” Excerpt: “…the gene that allowed us to speak may have something to do with a special kind of learning, The gene was first identified in a group of family members who had severe difficulties in speaking and understanding speech, and who were found to…

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Genotype, observed phenotype, and distinctly disordered behaviors

Schizophrenia not a single disease but multiple genetically distinct disorders September 15, 2014 By Jim Dryden News article excerpt: “Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.” My comment: Robert Cloninger and Jay R. Feierman were psychiatry post-doc residents at…

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Is the problem an internet echo or Feierman's ethics?

Docosahexaenoic acid (DHA) is an omega-3 fatty acid. It is found in cold water fatty fish… On 9/19/13, I posted here and to the evolutionary psychology yahoo group  (msg #152240) on the link between Aquatic Ape Theory, dietary DHA, my model, and brain development. Today, the moderator of the human ethology yahoo group posted a 9/13/13 link (msg # 49666) to Diet During Pregnancy and Early Life May Affect Children’s Behavior and Intelligence Excerpt: “Eating oily fish is also very…

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Behavior (3): All responses are RNA-mediated in bees

See: Honey bees as a model for understanding mechanisms of life history transitions. Excerpt: “In this review we discuss the physiological and genetic mechanisms of this behavioral transition, which include large scale changes in hormonal activity, metabolism, flight ability, circadian rhythms, sensory perception and processing, neural architecture, learning ability, memory and gene expression.” My comment: An earlier review by Eleckonich and Robinson (2000) “Organizational and activational effects of hormones on insect behavior” cited our 1996 review of epigenetically-effected organization and activation…

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RNA-mediated ecological adaptation is not evolution

Prehistoric Critters Change View of Mammal Evolution Three extinct squirrel-like species were identified from Jurassic-era fossils in China. By Molly Sharlach | September 12, 2014 Excerpt 1): “The fossils suggest that the slender animals spent time in trees, and had hands and feet adapted for grabbing branches. Their resemblance to present-day squirrels is a result of convergent evolution, as they belong to a lineage that diverged from that of modern mammals long ago.” My comment: Resemblance in the fossil record…

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Exploding genomes and chromosomal rearrangements via RNA-mediated events

Gibbon genome and the fast karyotype evolution of small apes This is an open access article reported as: Gibbon genome sequence deepens understanding of primates rapid chromosomal rearrangements Excerpt: The number of chromosomal rearrangements in the gibbons is remarkable, Rogers said. “It is like the genome just exploded and then was put back together,” he said. “Up until recently, it has been impossible to determine how one human chromosome could be aligned to any gibbon chromosome because there are so…

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Behavior (2): All responses are RNA-mediated not genetically-determined

Diana Maria Petrosanu also asked: “who was the author of the article that had stolen your ideas?“ I cannot recall claiming that anyone had stolen our ideas or my ideas. See: Behavior: The first response is RNA-mediated not genetically-determined. In subsequent published works, I extended what we detailed about the molecular epigenetics of sex differences in cell types from yeasts to mammals via examples from model organisms of RNA-mediated cell type differentiation in different species. That is why I was…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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