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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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It’s cell type differention, not cell fate determination (2)

See: It’s cell type differention, not cell fate determination High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions Excerpt: “…deviation from the derived models is a characteristic hallmark of methylation changes associated with cancer states suggesting that this phenomenon is mechanistically distinct from differentiation related methylation changes.” My comment: The article helps to detail the difference between facts about the molecular mechanisms of RNA-mediated events that lead to cell type differentiation and theories…

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Are evolutionary theorists 'nob ends'?

Interview – Prof Brian Cox and Robin Ince Robin Ince “Am I wrong to sometimes be scared of science idiots?” Brian Cox  “…my favoured response would be: ‘you bunch of utter nob ends’.  See also:  “The problem with today’s world is that everyone believes they have the right to express their opinion AND have others listen to it. The correct statement of individual rights is that everyone has the right to an opinion, but crucially, that opinion can be roundly…

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ALPHA GENOMIX LABORATORIES INC Alpha genomics (for those unfamiliar with their spelling) Re: On this team, Dr. Hani El Shawa, is also first author of Prenatal Ethanol Exposure Disrupts Intraneocortical Circuitry, Cortical Gene Expression, and Behavior in a Mouse Model of FASD. The Journal of Neuroscience, 27 November 2013, 33(48): 18893-18905. Excerpt: “Changes in gene expression reported in this study may be caused by altered DNA methylation, an epigenetic modification that cells use to mediate gene expression (Moore et al.,…

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No excuses: Creation and the meaning of organismal complexity

E.O. Wilson On ‘The Meaning Of Human Existence’ Excerpt: “We’re one species — glorious though we are — we are just one species out of an estimated eight million,” Wilson said. “At the present time, we only know almost exactly two million species — enough to give them a scientific name. Six million species are out there, maintaining the planet for us as an autonomous ecosystem and stabilization system. Book Excerpt: ‘The Meaning of Human Existence’ “Six million species are…

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Nutrient-dependent gene duplication in plants (but not animals?)

Divergence of Gene Body DNA Methylation and Evolution of Plant Duplicate Genes Excerpt 1) “A recent study demonstrated that the DNA methylation in promoter may play a significant role for functional divergence of duplicated genes in human [48].” Excerpt 1 from the cited work [48]: “For 73% of gene pairs, one copy is always hypomethylated compared with the other. This refutes the idea that [RNA-directed] DNA methylation of genes is strictly determined in a tissue-by-tissue manner and indicates the presence…

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Evolutionary theorists justify fear of the Ebola viruses

Scientists Rein In Fears of Ebola, a Virus Whose Mysteries Tend to Invite Speculation By CARL ZIMMER OCT. 13, 2014 Excerpt: “Pardis C. Sabeti, a geneticist at Harvard, and her colleagues have analyzed the genomes of Ebola viruses isolated from patients in Sierra Leone to reconstruct the history of the current outbreak. Their research indicates it was the result of a single infection, probably last December. Since then, the viruses have acquired new mutations as they have spread from person…

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Evolutionary theorists and evolutionary theists live under rocks

CRISPR/Cas: Not Just for DNA Anymore Excerpt 1) “Unless you’ve been living under a rock the past two years, you’ve heard of CRISPR/Cas9, an RNA-guided nuclease that’s redefining synthetic biology and genome engineering.” Excerpt 2) “The authors propose several additional applications as well, including… altering pre-mRNA splicing, and transcript tracking in live cells.” My comment: Are you an evolutionary theorist or evolutionary theist who has continued to ignore everything known about RNA-mediated events that link nutrient-uptake to altered pre-mRNA splicing…

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No understanding of biodiversity

No single explanation for biodiversity in Madagascar Excerpt: “The study is part of a larger body of research aimed at identifying the climate, geology and other features of the environment that help bring new species of plants and animals into being in an area, and then sustain once they’re there.” My comment: Like many studies, this one posits that new species automagically arise and are somehow sustained in ecological niches. Excerpt: “What governs the distribution of, say, a particular group of…

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Understanding physical forces of ecological variation and adaptation

Discovery of new subatomic particle, type of meson, to ‘transform’ understanding of fundamental force of nature   Excerpt: “Because the Ds3*(2860)ˉ particle contains a heavy charm quark it is easier for theorists to calculate its properties. And because it has spin 3, there can be no ambiguity about what the particle is,” adds Professor Gershon. “Therefore it provides a benchmark for future theoretical calculations. Improvements in these calculations will transform our understanding of how nuclei are bound together.” My comment:…

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Eliminating evolutionary theory

Does evolutionary theory need a rethink? Excerpt 1) “…the theory neglects key processes, say Kevin Laland and colleagues.” My comment: “Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans (Keller et al., 2007; Kohl, 2007; Villarreal, 2009; Vosshall, Wong, & Axel, 2000).” — Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. (2012) Excerpt 2) “Theory accommodates evidence through relentless synthesis…” My comment: “An…

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