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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior.…

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Not focused and self-aggrandizing

Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity…

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Nutrient-dependent cooperation vs cannibalism (video)

Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections reported as: Researchers find surprising relationships in brain signaling Excerpt: “…the glycoprotein Reelin is crucial to developing healthy neural networks. Logically, taking away the two receptors that Reelin is known to act on early in the brain’s development should create the same malformations as taking away Reelin itself.  It didn’t. My comment: Differences in glucose metabolism lead to differences in cell types via receptor-mediated behavior. Mutated receptors are ecological dead ends because…

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Cell-type differentiation

How Do You Know When You’ve Found Them All? A Question That Applies To Beetles and Cancer Genes Alike by Carl Zimmer Conclusion: “Cancer biologists and beetle experts are not all that different when you think about it. They walk the same foggy road together, a long way from the end.” My comment: Only the cancer biologists and beetle experts who believe in mutation-driven evolution are walking a road together. It’s not a foggy road. It’s brain fog that makes them similar.…

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Another powerful refutation of mutation-initiated natural selection

Brain regions thought to be uniquely human share many similarities with monkeys Date: January 28, 2014 Summary: New research suggests a surprising degree of similarity in the organization of regions of the brain that control language and complex thought processes in humans and monkeys. The study also revealed some key differences. The findings may provide valuable insights into the evolutionary processes that established our ties to other primates but also made us distinctly human. Excerpt: “…some uniquely human cognitive traits may…

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The new light of chromosomal rearrangements

SCIENCE Seeing X Chromosomes in a New Light By CARL ZIMMER JAN. 20, 2014 NY TIMES Excerpt 1: In the journal Neuron, a team of scientists has unveiled an unprecedented view of X-chromosome inactivation in the body. They found a remarkable complexity to the pattern in which the chromosomes were switched on and off. My comment: The remarkable complexity of nutrient-dependent pheromone-controlled chromosomal rearrangements that led to difference in sex chromosomes was detailed in our 1996 Hormones and Behavior review article in the section on: Genetic…

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Darwinian theories vs Darwin's facts

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated natural selection in the video. For comparison, tenOever on microRNA and Vaccines  addresses what is currently known about glucose-dependent RNA-mediated amino acid substitutions and self vs non-self identification in viruses to living species with varying degrees of nutrient-dependent pheromone-controlled ecologically-adapted organismal complexity.…

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Chromosomal rearrangements and ecological adaptations

PZ Myers is an atheistic biology teacher who believes in mutation-driven evolution. Myers thinks I am  “crank” and he compared me to John A. Davison, who Myers also thinks is a crank. According to Myers, Davison was a crank for proposing a theory that Evolution was all due to chromosome rearrangements… Discussion of who’s the crank ensured with more misinformation than I have ever seen spread by evolutionary theorists and atheists across 740 posts to Myers blog. Every comment I made was…

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The wrong picture of our evolution

“We have built a picture of our evolution based on the morphology of fossils and it was wrong.” I’ve repeatedly cited the latest literature, especially in the context of Skull 5. The article linked below is another clear representation of how the wrong picture of our evolution was built via a series of misrepresentations that ignored biological constraints while theorists touted mutation-initiated natural selection. Why don’t they simply admit that they are wrong, so others can move on? Fifty years…

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96 fixed amino acid substitutions, not 96 genes

19 December, 2013 – 09:31 april holloway Entire Neanderthal genome finally mapped – with amazing results Excerpt (with my emphasis): “Only 96 genes responsible for making proteins in cells are different between modern humans and Neanderthals. Intriguingly, some of the gene differences involve ones involved in both immune responses and the development of brain cells in people.” “Somewhere within these 96 genes may lay the answer to why Neanderthals and Denisovans became extinct.” Journal article: The complete genome sequence of a Neanderthal from the Altai Mountains Excerpt (with…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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