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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Soft atheism: a case for Creation

The Case for ‘Soft Atheism’ By GARY GUTTING   Excerpt: “…much as I admire Dawkins’s work in evolutionary biology and in enhancing the public understanding of science…” My comment: The case against evolution. Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes Biophysical constraints that enable the intermolecular tethering of RNA to DNA also link the epigenetic landscape to the physical landscape of DNA via the conserved molecular mechanisms of RNA-mediated events in species from…

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Nutrition, pheromones and cancer (2)

See: Nutrition, pheromones and cancer Despite the inaccurate reporting of exeperimental evidence, the link from the nutrient-dependent pheromone-controlled microRNA / messenger RNA balance is becoming clearer. Unfortunately, due to the inaccurate reporting, others may need to take the free course: Epigenetic Control of Gene Expression, before they can begin to understand the scientific progress in cancer research, which is occurring because some researchers have dispensed with the pseudoscientific nonsense of evolutionary theory. See for example: Biogenesis of intronic miRNAs located…

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Ecologically linked adapted ants and brains

Ants Swarm Like Brains Think A neuroscientist studies ant colonies to understand feedback in the brain. By Carrie Arnold April 24, 2014 Excerpt: “The behavior of each individual in the group is set by the rate at which it meets other ants and a set of basic rules. Its behavior alters that of its neighbors, which in turn affects the original ant, in a classic example of feedback. The result is astonishing, complex behavior.” My comment: The molecular mechanisms of…

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MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior.…

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Not focused and self-aggrandizing

Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity…

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Nutrient-dependent cooperation vs cannibalism (video)

Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections reported as: Researchers find surprising relationships in brain signaling Excerpt: “…the glycoprotein Reelin is crucial to developing healthy neural networks. Logically, taking away the two receptors that Reelin is known to act on early in the brain’s development should create the same malformations as taking away Reelin itself.  It didn’t. My comment: Differences in glucose metabolism lead to differences in cell types via receptor-mediated behavior. Mutated receptors are ecological dead ends because…

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Cell-type differentiation

How Do You Know When You’ve Found Them All? A Question That Applies To Beetles and Cancer Genes Alike by Carl Zimmer Conclusion: “Cancer biologists and beetle experts are not all that different when you think about it. They walk the same foggy road together, a long way from the end.” My comment: Only the cancer biologists and beetle experts who believe in mutation-driven evolution are walking a road together. It’s not a foggy road. It’s brain fog that makes them similar.…

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Another powerful refutation of mutation-initiated natural selection

Brain regions thought to be uniquely human share many similarities with monkeys Date: January 28, 2014 Summary: New research suggests a surprising degree of similarity in the organization of regions of the brain that control language and complex thought processes in humans and monkeys. The study also revealed some key differences. The findings may provide valuable insights into the evolutionary processes that established our ties to other primates but also made us distinctly human. Excerpt: “…some uniquely human cognitive traits may…

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The new light of chromosomal rearrangements

SCIENCE Seeing X Chromosomes in a New Light By CARL ZIMMER JAN. 20, 2014 NY TIMES Excerpt 1: In the journal Neuron, a team of scientists has unveiled an unprecedented view of X-chromosome inactivation in the body. They found a remarkable complexity to the pattern in which the chromosomes were switched on and off. My comment: The remarkable complexity of nutrient-dependent pheromone-controlled chromosomal rearrangements that led to difference in sex chromosomes was detailed in our 1996 Hormones and Behavior review article in the section on: Genetic…

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Darwinian theories vs Darwin's facts

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated natural selection in the video. For comparison, tenOever on microRNA and Vaccines  addresses what is currently known about glucose-dependent RNA-mediated amino acid substitutions and self vs non-self identification in viruses to living species with varying degrees of nutrient-dependent pheromone-controlled ecologically-adapted organismal complexity.…

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