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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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A molecular visualizer of worthwhile molecular biology

September 16, 2014
James Kohl
Diseases & Disorders, Pharmacogenomics
No Comments

Ruben Gonzalez Jr.: Molecular Visualizer Associate Professor and Director of Graduate Studies, Department of Chemistry, Columbia University. Age 42 By Jef Akst | September 1, 2014 Excerpt: “Much of his group’s current work involves extending discoveries about translation in E. coli to the process in eukaryotes, with an eye toward human health and disease.” My comment: That sums up the frustration that other serious scientists must share when they hear pseudoscientific nonsense touted about mutations, natural selection, and the evolution…

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RNA-mediated species diversification from microbes to primates

September 16, 2014
James Kohl
Ecology, Pharmacogenomics, Physics
No Comments

Mycobacteriophage-drived diversification of Mycobacterium abscessus Biology Direct (15 September 2014) OPEN ACCESS Excerpt (with my emphasis): “Widespread occurrence of phage sequences in almost all studied M. abscessus complex isolates suggests that the rate of prophage invasion is faster than the rate of mutation, implying rapid evolution of M. abscessus.” My comment: The faster rate of prophase invasion suggests ecological adaptations occur more rapidly than evolution. That may be why no experimental evidence of biologically-based cause and effect suggests that evolution…

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RNA-mediated events found everywhere

September 15, 2014
James Kohl
Adaptations, Diseases & Disorders, Ecology, Pharmacogenomics
No Comments

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA Related articles Related blog posts on this site Reported as Scientists discover RNA modifications in some unexpected places Excerpt 1): “…there are multiple types of RNA, three of which—messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA)—are essential for proper protein production. Moreover, RNAs that are synthesized during the process known as transcription often undergo subsequent changes, which are referred to as “post-transcriptional modifications.” My comment: These microRNA/messenger RNA-mediated…

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Reseachers think copy number variation is genetically determined

September 15, 2014
James Kohl
Adaptations, Diseases & Disorders, Ecology
No Comments

Researchers develop new type of genetic test for identifying developmental disorders Excerpt: “…the team sought to find specific genes responsible for certain development disorders, and they appear to have done just that.” My comment: The genes cannot be responsible for any developmental disorders because morphological and behavioral phenotypes arise in the context of RNA-mediated events that differentiate cell types via amino acid substitutions. See also: Genotype, observed phenotype, and distinctly disordered behaviors Genetically distinct behavioral disorders are RNA-mediated just like…

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Some neuroscientists think a mutation led to human language development

September 15, 2014
James Kohl
Adaptations, Diseases & Disorders, Ecology
No Comments

Neuroscientists identify key role of language gene Excerpt: “Neuroscientists have found that a gene mutation that arose more than half a million years ago may be key to humans’ unique ability to produce and understand speech.” Excerpt: “…the gene that allowed us to speak may have something to do with a special kind of learning, The gene was first identified in a group of family members who had severe difficulties in speaking and understanding speech, and who were found to…

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Genotype, observed phenotype, and distinctly disordered behaviors

September 15, 2014
James Kohl
Diseases & Disorders, Ecology, Human Brain, Neuronal Plasticity, Variations
One Comment

Schizophrenia not a single disease but multiple genetically distinct disorders September 15, 2014 By Jim Dryden News article excerpt: “Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.” My comment: Robert Cloninger and Jay R. Feierman were psychiatry post-doc residents at…

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Is the problem an internet echo or Feierman's ethics?

September 15, 2014
James Kohl
Diseases & Disorders, Pharmacogenomics
No Comments

Docosahexaenoic acid (DHA) is an omega-3 fatty acid. It is found in cold water fatty fish… On 9/19/13, I posted here and to the evolutionary psychology yahoo group  (msg #152240) on the link between Aquatic Ape Theory, dietary DHA, my model, and brain development. Today, the moderator of the human ethology yahoo group posted a 9/13/13 link (msg # 49666) to Diet During Pregnancy and Early Life May Affect Children’s Behavior and Intelligence Excerpt: “Eating oily fish is also very…

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Behavior (3): All responses are RNA-mediated in bees

September 14, 2014
James Kohl
Adaptations, Ecology, Human Pheromones, Model Organisms
No Comments

See: Honey bees as a model for understanding mechanisms of life history transitions. Excerpt: “In this review we discuss the physiological and genetic mechanisms of this behavioral transition, which include large scale changes in hormonal activity, metabolism, flight ability, circadian rhythms, sensory perception and processing, neural architecture, learning ability, memory and gene expression.” My comment: An earlier review by Eleckonich and Robinson (2000) “Organizational and activational effects of hormones on insect behavior” cited our 1996 review of epigenetically-effected organization and activation…

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RNA-mediated ecological adaptation is not evolution

September 14, 2014
James Kohl
Adaptations, Ecology, Model Organisms
No Comments

Prehistoric Critters Change View of Mammal Evolution Three extinct squirrel-like species were identified from Jurassic-era fossils in China. By Molly Sharlach | September 12, 2014 Excerpt 1): “The fossils suggest that the slender animals spent time in trees, and had hands and feet adapted for grabbing branches. Their resemblance to present-day squirrels is a result of convergent evolution, as they belong to a lineage that diverged from that of modern mammals long ago.” My comment: Resemblance in the fossil record…

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Exploding genomes and chromosomal rearrangements via RNA-mediated events

September 13, 2014
James Kohl
Adaptations, Ecology, Model Organisms, Variations
2 Comments

Gibbon genome and the fast karyotype evolution of small apes This is an open access article reported as: Gibbon genome sequence deepens understanding of primates rapid chromosomal rearrangements Excerpt: The number of chromosomal rearrangements in the gibbons is remarkable, Rogers said. “It is like the genome just exploded and then was put back together,” he said. “Up until recently, it has been impossible to determine how one human chromosome could be aligned to any gibbon chromosome because there are so…

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