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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Comparing divergent model organisms

Comparative analysis of the transcriptome across distant species Excerpt: Overall, our results underscore the importance of comparing divergent model organisms to human to highlight conserved biological principles (and disentangle them from lineage-specific adaptations). My comment: In the detailed comparisons of divergent model organisms portrayed in Nutrient-dependent/pheromone-controlled adaptive evolution: a model, I underscored what is known about cell type differentiation in species from microbes to man. By placing what is known into the context of nutrient-dependent amino acid substitutions and biodiversity…

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A microRNA-mediated mechanism that is epigenetically inherited

Pregnancy Stress Spans Generations The stressors a female rat experiences during pregnancy can have repercussions for her granddaughters, a study shows. By Anna Azvolinsky | August 7, 2014 Excerpt: “These changes could be the result of a microRNA (miRNA)-mediated mechanism, which may be epigenetically inherited across generations.” My comment:  There is currently no alternative explanation for these changes. However, a model of how nutrient-dependent pheromone-controlled amino acid substitutions link cell type differentiation (e.g., from the epigenetic landscape to the physical landscape of DNA in…

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Epimutations: Attacking pseudoscientific dogmas

“Our principle aim in the lab is to attack scientific dogmas.” That claim went missing from the Oded Rechavi lab web page  in September 2014. Perhaps it drew unwanted attention to the lab. No matter, the short perspective: RNA and dynamic nuclear organization helped to clarify the fact that “…the interactions between pre-mRNA and proteins fine-tune alternative splicing in a manner that can gradually create new protein functionalities without the need to create additional genes and without affecting existing proteins…

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Order and disorder: Ecological adaptations not mutations

In the context of order and disorder that includes what is known about quantum physics and light-induced amino acid substitutions in plants and animals, as well as the control of the functional rearrangement of influenza hemagglutinin, I’m beginning to see even more confusion/obfuscation enter the picture of biophysically-constrained ecological adaptations. The nutrient-dependent ecological adaptations are now being put into the context of mutation-initiated natural selection and the evolution of biodiversity (i.e., “Evolution for Dummies”). ECOLOGICAL ADAPTATIONS (not mutations) Nutrient-dependent changes in…

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microRNAs differentiate neuronal cell types

microRNAs: key triggers of neuronal cell fate Excerpt: “In light of the fact that miRNAs have very precise expression patterns depending on the cell type, tissue and/or developmental stage; it is challenging to generalize a single mechanism to regulate their expression and to identify the target genes that each miRNA has during each stage of neurogenesis. Thus, the combination of bioinformatic tools and experimental techniques will help in the study of miRNAs role in early neurogenesis and how they, their…

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microRNAs and species relationships

Flaws emerge in RNA method to build tree of life Study finds problems with alluringly simple way to tease out evolutionary relationships through microRNA. Amy Maxmen 28 July 2014 Excerpt 1:  “…some pieces of RNA are only expressed at particular moments in an animal’s lifetime, whereas genes in the genome are steady.” Excerpt 2): “…microRNAs cannot alone unveil species relationships.” My comment: Until earlier today, I was not aware that anyone had been touting the evolution of microRNA (miRNA) or…

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Drunks and Monkeys: Pseudoscientific nonsense

Drunks and Monkeys Understanding our primate ancestors’ relationship with alcohol can inform its use by modern humans. By Robert Dudley | June 1, 2014 Excerpt: “…if the right kinds of bacteria are also present, fermentation will stabilize certain foodstuffs (think cheese, yogurt, sauerkraut, and kimchi, for example).” My comment:  Epigenetic changes induced by ethanol in astrocytes link histone acetylation, DNA methylation, and non-coding microRNAs in the developing and adult brain from frugivory to the nutrient-dependent de novo creation of olfactory receptor genes in bats. The…

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The quantum biology of consciousness

Everything known about quantum biology “…suggests conscious experience is intrinsically connected to the fine-scale structure of space–time geometry, and that consciousness could be deeply related to the operation of the laws of the universe.” See for review: Consciousness in the universe: A review of the ‘Orch OR’ theory. These laws of the universe might lead others to think in terms of “laws of biology” (biological laws). Indeed, many informed scientists could expect that ecological, social, and neurogenic niche construction would result…

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Behavior is receptor-mediated

Mechanism explains complex brain wiring Excerpt: “How neurons are created and integrate with each other is one of biology’s greatest riddles.” My comment: The biology of behavior is receptor-mediated. If you can convince people it is not receptor-mediated, you can probably convince them that the different morphological and behavioral phenotypes of species from microbes to man somehow evolved via mutations and natural selection rather than via RNA-mediated events. However, without the nutrient-dependent pheromone-controlled de novo creation of olfactory receptor genes,…

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Genes and Race: Human History?

Roundup of Book Reviews of Nicholas Wade’s A Troublesome Inheritance My comment: Many reviewers of Wade’s book on genes and race appear to think he has accurately represented issues of differences in cell types that evolutionary theorists associate with mutations, natural selection, and the evolution of human biodiversity. This may be cause for concern among those who are interested in accurate representations of biologically-based cause and effect. In this century, it has become clear that ecological variation results in biodiversity, which…

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