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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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The new light of chromosomal rearrangements

SCIENCE Seeing X Chromosomes in a New Light By CARL ZIMMER JAN. 20, 2014 NY TIMES Excerpt 1: In the journal Neuron, a team of scientists has unveiled an unprecedented view of X-chromosome inactivation in the body. They found a remarkable complexity to the pattern in which the chromosomes were switched on and off. My comment: The remarkable complexity of nutrient-dependent pheromone-controlled chromosomal rearrangements that led to difference in sex chromosomes was detailed in our 1996 Hormones and Behavior review article in the section on: Genetic…

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Darwinian theories vs Darwin's facts

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated natural selection in the video. For comparison, tenOever on microRNA and Vaccines  addresses what is currently known about glucose-dependent RNA-mediated amino acid substitutions and self vs non-self identification in viruses to living species with varying degrees of nutrient-dependent pheromone-controlled ecologically-adapted organismal complexity.…

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Chromosomal rearrangements and ecological adaptations

PZ Myers is an atheistic biology teacher who believes in mutation-driven evolution. Myers thinks I am  “crank” and he compared me to John A. Davison, who Myers also thinks is a crank. According to Myers, Davison was a crank for proposing a theory that Evolution was all due to chromosome rearrangements… Discussion of who’s the crank ensured with more misinformation than I have ever seen spread by evolutionary theorists and atheists across 740 posts to Myers blog. Every comment I made was…

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The wrong picture of our evolution

“We have built a picture of our evolution based on the morphology of fossils and it was wrong.” I’ve repeatedly cited the latest literature, especially in the context of Skull 5. The article linked below is another clear representation of how the wrong picture of our evolution was built via a series of misrepresentations that ignored biological constraints while theorists touted mutation-initiated natural selection. Why don’t they simply admit that they are wrong, so others can move on? Fifty years…

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96 fixed amino acid substitutions, not 96 genes

19 December, 2013 – 09:31 april holloway Entire Neanderthal genome finally mapped – with amazing results Excerpt (with my emphasis): “Only 96 genes responsible for making proteins in cells are different between modern humans and Neanderthals. Intriguingly, some of the gene differences involve ones involved in both immune responses and the development of brain cells in people.” “Somewhere within these 96 genes may lay the answer to why Neanderthals and Denisovans became extinct.” Journal article: The complete genome sequence of a Neanderthal from the Altai Mountains Excerpt (with…

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Jay R. Feierman

In his posts that I have linked below, Jay R. Feierman takes us from random mutations on which natural selection acts to natural selection for phenotypes and changes in the brain that lead to increased reproductive success. According to him, the change in the brain can be called an adaptation. In my model, ecological variation and nutrient-dependent pheromone-controlled epigenetically-effected ecological, social, neurogenic, and socio-cognitive niche construction enable organismal complexity of the human brain. Ecological variation links the epigenetic landscape to…

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Don't tell the Creationists

Misquoting Science in the Texas Textbook Battles James A. Shapiro Author, ‘Evolution: A View from the 21st Century’; Professor of Microbiology, University of Chicago Posted: 12/05/2013 3:57 pm Excerpt: “Uncovering the molecular mechanisms by which living organisms modify their genomes is a major accomplishment of late 20th Century molecular biology.” Collectively, I call these processes Natural Genetic Engineering. Symbiogenetic cell fusions, horizontal DNA transfer, mutagenic DNA repair, reverse transcription of RNA into DNA, mobile genetic elements, interspecific hybridization and whole…

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Targeting a cancer gene

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous masterminds of malignancies.” and see K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions [subscription required] Excerpt: “…initial evaluation of our compounds in lung cancer cell lines suggests allele-specific impairment of K-Ras function.” My comment: 1) They ignored any aspect…

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Alternative splicings (very technical)

From time to time I try to update my knowledge base on specific aspects included in my model. Here is the link to an open access article that may be of interest to others who want to learn more about biologically based cause and effect. This is not the type of information that you are likely to see in news reported by science journalists. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition Excerpt 1) DNA…

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Pulses of olfactory/pheromonal input

Signal and noise: Spike correlations in the olfactory system by John Hewitt Excerpt: “The olfactory system is not so much a hard-wired telephone network where channels can be instantaneously specified and connected by number codes, and then used to transmit further codes. There is significant overgrowth and back-pruning in olfactory networks during development, and some ongoing cell replacement, but once etched, many of its larger features remain stable.” My comment: This comparison is meaningful: “…any message can not stand out…

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