Add your custom tagline title here.

Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

Please subscribe and share with your friends and colleagues.


Drunks and Monkeys: Pseudoscientific nonsense

Drunks and Monkeys Understanding our primate ancestors’ relationship with alcohol can inform its use by modern humans. By Robert Dudley | June 1, 2014 Excerpt: “…if the right kinds of bacteria are also present, fermentation will stabilize certain foodstuffs (think cheese, yogurt, sauerkraut, and kimchi, for example).” My comment:  Epigenetic changes induced by ethanol in astrocytes link histone acetylation, DNA methylation, and non-coding microRNAs in the developing and adult brain from frugivory to the nutrient-dependent de novo creation of olfactory receptor genes in bats. The…

Read More

The quantum biology of consciousness

Everything known about quantum biology “…suggests conscious experience is intrinsically connected to the fine-scale structure of space–time geometry, and that consciousness could be deeply related to the operation of the laws of the universe.” See for review: Consciousness in the universe: A review of the ‘Orch OR’ theory. These laws of the universe might lead others to think in terms of “laws of biology” (biological laws). Indeed, many informed scientists could expect that ecological, social, and neurogenic niche construction would result…

Read More

Behavior is receptor-mediated

Mechanism explains complex brain wiring Excerpt: “How neurons are created and integrate with each other is one of biology’s greatest riddles.” My comment: The biology of behavior is receptor-mediated. If you can convince people it is not receptor-mediated, you can probably convince them that the different morphological and behavioral phenotypes of species from microbes to man somehow evolved via mutations and natural selection rather than via RNA-mediated events. However, without the nutrient-dependent pheromone-controlled de novo creation of olfactory receptor genes,…

Read More

Genes and Race: Human History?

Roundup of Book Reviews of Nicholas Wade’s A Troublesome Inheritance My comment: Many reviewers of Wade’s book on genes and race appear to think he has accurately represented issues of differences in cell types that evolutionary theorists associate with mutations, natural selection, and the evolution of human biodiversity. This may be cause for concern among those who are interested in accurate representations of biologically-based cause and effect. In this century, it has become clear that ecological variation results in biodiversity, which…

Read More

Soft atheism: a case for Creation

The Case for ‘Soft Atheism’ By GARY GUTTING   Excerpt: “…much as I admire Dawkins’s work in evolutionary biology and in enhancing the public understanding of science…” My comment: The case against evolution. Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes Biophysical constraints that enable the intermolecular tethering of RNA to DNA also link the epigenetic landscape to the physical landscape of DNA via the conserved molecular mechanisms of RNA-mediated events in species from…

Read More

Nutrition, pheromones and cancer (2)

See: Nutrition, pheromones and cancer Despite the inaccurate reporting of exeperimental evidence, the link from the nutrient-dependent pheromone-controlled microRNA / messenger RNA balance is becoming clearer. Unfortunately, due to the inaccurate reporting, others may need to take the free course: Epigenetic Control of Gene Expression, before they can begin to understand the scientific progress in cancer research, which is occurring because some researchers have dispensed with the pseudoscientific nonsense of evolutionary theory. See for example: Biogenesis of intronic miRNAs located…

Read More

Ecologically linked adapted ants and brains

Ants Swarm Like Brains Think A neuroscientist studies ant colonies to understand feedback in the brain. By Carrie Arnold April 24, 2014 Excerpt: “The behavior of each individual in the group is set by the rate at which it meets other ants and a set of basic rules. Its behavior alters that of its neighbors, which in turn affects the original ant, in a classic example of feedback. The result is astonishing, complex behavior.” My comment: The molecular mechanisms of…

Read More

MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior.…

Read More

Not focused and self-aggrandizing

Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity…

Read More

Nutrient-dependent cooperation vs cannibalism (video)

Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections reported as: Researchers find surprising relationships in brain signaling Excerpt: “…the glycoprotein Reelin is crucial to developing healthy neural networks. Logically, taking away the two receptors that Reelin is known to act on early in the brain’s development should create the same malformations as taking away Reelin itself.  It didn’t. My comment: Differences in glucose metabolism lead to differences in cell types via receptor-mediated behavior. Mutated receptors are ecological dead ends because…

Read More