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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Nutrient-dependent erythropoiesis and anemia

A critical role for mTORC1 in erythropoiesis and anemia Excerpt 1): “Cells must coordinate their rate of growth and proliferation with the availability of nutrients. mTOR , a serine-threonine kinase, is one the key proteins responsible for nutrient signaling in eukaryotic cells. mTOR is activated by conditions that signal energy abundance, such as the availability of amino acids, growth factors, and intracellular ATP. Activated mTOR then phosphorylates a set of downstream targets that promote anabolic processes, such as protein translation…

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Evolutionary heritage or ecological adaptation? Racism versus reality

Jewish Heritage Written in DNA Fully sequenced genomes of more than 100 Ashkenazi people clarify the group’s history and provide a reference for researchers and physicians trying to pinpoint disease-associated genes. By Kate Yandell | September 9, 2014 Excerpt: These results are compatible with those of prior work on mitochondrial DNA (mtDNA), which is passed on maternally. This prior work suggested that Ashkenazi men from the Middle East intermarried with local European women. The Ashkenazi population “hasn’t been likely as…

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A relatively young branch of science called epigenetics

Epigenetics: genes, environment and the generation game New research claims that environmental factors affect not just an individual’s genes but those of their offspring too. Diabetes, obesity – even certain phobias – may all be influenced by the behaviour of our forebears by Angela Saini, The Observer, Saturday 6 September 2014 Excerpt 1): “…she was kept on a near-starvation diet when she was close to giving birth.” Excerpt 2: with my emphasis): This puzzling study, published last month, echoes many…

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Insect homology and diversity attributed to mutations

Ancient homology underlies adaptive mimetic diversity across butterflies Excerpt: “Surprisingly, our results suggest that modulation of this conserved developmental gene has occurred in tandem between these two deeply divergent butterfly lineages, implying an unexpected and remarkable level of predictability in the evolutionary process.” Reported as: A single evolutionary road may lead to Rome Excerpt: “Copying errors and genomic viruses directly lead to the wing patterns of these beautiful butterflies,” Gallant said. “It’s these accidents that allow the evolutionary process to…

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Biophysically constrained beginnings of RNA and DNA

Any anonymous participant in the discussion of: DNA may have had humble beginnings as nutrient carrier (Sep 01, 2014 by Adam Hadhazy) asks: “when are you going to keep quiet?” In a series of responses, I have explained the problem I have with honoring his request. The following excerpts from Wikipedia and other sources are loosely strung together because there is no point to providing more extensive details of biologically-based cause and effect until others accept the fact that mutations…

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Baby talk: More misrepresentations of ecological adaptations

Evolution’s Baby Steps by Carl Zimmer Excerpt 1) “When organisms find themselves in a new environment, they develop in a way that helps them cope with their new surroundings. Their descendants may acquire mutations that encode that anatomy in their genes. Eventually evolution takes them beyond where plasticity alone could take them.” My comment: It’s time for science journalists to stop touting this nonsense (above). Ecological variation leads from nutrient uptake in new environments to RNA-mediated amino acid substitutions. If…

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Comparing divergent model organisms

Comparative analysis of the transcriptome across distant species Excerpt: Overall, our results underscore the importance of comparing divergent model organisms to human to highlight conserved biological principles (and disentangle them from lineage-specific adaptations). My comment: In the detailed comparisons of divergent model organisms portrayed in Nutrient-dependent/pheromone-controlled adaptive evolution: a model, I underscored what is known about cell type differentiation in species from microbes to man. By placing what is known into the context of nutrient-dependent amino acid substitutions and biodiversity…

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A microRNA-mediated mechanism that is epigenetically inherited

Pregnancy Stress Spans Generations The stressors a female rat experiences during pregnancy can have repercussions for her granddaughters, a study shows. By Anna Azvolinsky | August 7, 2014 Excerpt: “These changes could be the result of a microRNA (miRNA)-mediated mechanism, which may be epigenetically inherited across generations.” My comment:  There is currently no alternative explanation for these changes. However, a model of how nutrient-dependent pheromone-controlled amino acid substitutions link cell type differentiation (e.g., from the epigenetic landscape to the physical landscape of DNA in…

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Epimutations: Attacking pseudoscientific dogmas

“Our principle aim in the lab is to attack scientific dogmas.” That claim went missing from the Oded Rechavi lab web page  in September 2014. Perhaps it drew unwanted attention to the lab. No matter, the short perspective: RNA and dynamic nuclear organization helped to clarify the fact that “…the interactions between pre-mRNA and proteins fine-tune alternative splicing in a manner that can gradually create new protein functionalities without the need to create additional genes and without affecting existing proteins…

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Order and disorder: Ecological adaptations not mutations

In the context of order and disorder that includes what is known about quantum physics and light-induced amino acid substitutions in plants and animals, as well as the control of the functional rearrangement of influenza hemagglutinin, I’m beginning to see even more confusion/obfuscation enter the picture of biophysically-constrained ecological adaptations. The nutrient-dependent ecological adaptations are now being put into the context of mutation-initiated natural selection and the evolution of biodiversity (i.e., “Evolution for Dummies”). ECOLOGICAL ADAPTATIONS (not mutations) Nutrient-dependent changes in…

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