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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Quantum Darwinism (4)

April 15, 2021
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference, What's in the News
No Comments

How metformin affects various malignancies by means of microRNAs: a brief review 4/13/21 Metformin adjusts cellular energy metabolism through…an important metabolic sensor that is activated under cellular stress conditions and limits energy consumption by affecting ATP production and consumption [1, 2]. The link from naturally occurring light-activated carbon fixation to God’s ATP-dependent Creation of RNA, protonated RNA interference, and biophysically constrained viral latency became clearer in 1964. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism…

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Quantum Darwinism (3)

April 15, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference
No Comments

“Quantum biology” is quantum Darwinism Starting from…discovery of quantum coherence in low-temperature photosynthetic microbes in 2007, quantum coherence is emerging as a general principle of biological systems. See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. Theorists chose neo-Darwinian pseudoscientific nonsense about beneficial mutations and evolution via natural selection across billions to millions of years instead of the explanatory power of quantum Darwinism. Their ignorance…

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Quantum Darwinism (2)

April 9, 2021
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, Subatomic, Variations
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Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid 2/5/21 Orgel and Szostak introduced an amino group into 2′- and 3′-positions9, which enabled effective RNA copying due to acceleration of the ligation reaction10,11. Reported as: Origins of life could have started with DNA-like XNAs 4/6/21 …shorter L-aTNA fragments came together and linked up with each other on the longer L-aTNA template. Critically, this happened in the presence of a compound, called N-cyanoimidazole, and a metal ion, like manganese, both of…

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Quantum Darwinism (1)

April 8, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
No Comments

See first: Pheromones protect us from viruses parts 1-10 For a historical perspective on the development of healthy ecosystems, see: Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) (1994) and From Fertilization to Adult Sexual Behavior (1996) For links from quantum Darwinism to all energy-dependent biophysically constrained biodiversity, see also: Quantum Criticality at the Origin of Life 3/3/15 The number of proteins grows exponentially with the number n of amino acids… Peptide synthesis at the…

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Pheromones protect us from viruses (10)

April 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, Subatomic, Variations
One Comment

Twitter Profile: MicroRNA.pro, http://Autophagy.pro & http://RNA-mediated.com link subatomic particles from pH-dependent peptide synthesis to sympatric speciation and healthy ecosystems. Before 4/6/21, I had contributed 40,000 tweets @microRNApro to support claims about how light-activated carbon fixation is linked to healthy longevity in more than 118,400 indexed publications that mention ‘microRNA.’ For a historical perspective on the development of healthy ecosystems, see: Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) (1994) “The specificity of pheromonal regulation depends…

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Pheromones protect us from viruses (9)

April 4, 2021
James Kohl
biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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It may be a form of insanity that prevents theorists, atheists, and Communists from addressing the facts that have been detailed in the context of: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 …a class of agents called covalent peptidomimetic inhibitors that work by using strings of unnatural amino acids to bind to specific target proteins. See for instance:  A two-amino acid change in the hemagglutinin of the 1918 influenza virus…

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Pheromones protect us from viruses (8)

March 31, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed
No Comments

See first: Pheromones protect us from viruses (7) Summary: When others link God’s Creation of anti-entropic virucidal light to pH-dependent biophysically constrained viral latency via His Creation of water, which is required for the creation of all oxygen-dependent life on Earth, we will see how God’s Creation of Genotypes in all species once protected them, and us, from the virus-driven degradation of messenger RNA. More than 118,000 indexed published articles mention ‘microRNA.’ It is long past time for theorists to…

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Pheromones protect us from viruses (7)

March 30, 2021
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
One Comment

It’s been more than one year since Guenther Witzany published What is Life? 3/18/20 “A new definition of life must integrate the current empirical knowledge about interactions between cells, viruses, and RNA networks to provide a better explanatory power than the twentieth century narrative.” The need for the new definition of life is consistent with my claims from “What is life when it is not protected from virus-driven entropy.” It’s been 5 years since this virtual conference presentation on 3/30/16. The…

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Pheromones protect us from viruses (6)

March 25, 2021
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, Light Energy, Model Organisms, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic
No Comments

The Origin of Species (1859) linked the observations of Charles Darwin from his “conditions of life” to all biodiversity on Earth via the physiology of reproduction in all species. Scientific progress across disciplines has since linked his claims to an effective treatment, protonated RNA interference, for virus-driven pathology. See: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 Our recent neutron crystallographic study of the ligand-free SARS-CoV-2 Mpro provided direct visualization of…

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Pheromones protect us from viruses (5)

March 24, 2021
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
No Comments

Timothy Normand Miller (Digital circuit designer, software engineer, master debugger, computer engineering PhD, former college professor) @theosib2 wrote: If they didn’t mention God, then they didn’t make a link to God’s creation of anything. Adam Karaba (Assistant Professor, Department of Organic Technology, UCT Prague) @KarabaAdam wrote: I really dont like when anybody forces his faith into science, or issue his faith as a science. There is no place for such things in the science. It is not rational even ethic.…

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