Add your custom tagline title here.

Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

Please subscribe and share with your friends and colleagues.

God’s microRNA-mediated Creation of genotypes (7)

October 1, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
One Comment

Molecular Biology Empowering a community publishing articles in Molecular Biology, including RNA biology, chromatin and epigenetics, gene expression, translation, DNA replication and repair, nuclear organization, gene editing, and much more. Advanced Search 13,006 results for microRNA Most recent: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 See also: 43,893 results for viruses and Micrornas 73,770 results for Potential Therapeutic Effect of Micrornas See for comparison: More than 128,300 indexed publications on PubMed…

Read More

God’s microRNA-mediated Creation of genotypes (6)

October 1, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
No Comments

microRNA 128,290 results. I was too busy to post links to articles when the total number of indexed publications hit 128,000. But see: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 These results indicate possible therapeutic use of stable anti-miR-24, albeit administered by other routes, in diseases that are alleviated by STING. miR-24 is known to affect brain development and fetal neuronal differentiation [69]; however these effects should have little bearing on…

Read More

God’s microRNA-mediated Creation of genotypes (5)

September 21, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
No Comments

Summary: Energy-dependent changes in single nucleotide polymorphisms (SNPs) in microribonucleic acids (microRNAs/miRNAs) were linked from femotosecond blasts of UV light to DNA repair via an extremely sensitive assay for the label-free optical detection and suppression of interfering effects caused by non-specific binding. Interactions in Augmented and Mixed Reality: An Overview 9/20/21 (This article belongs to the Special Issue Extended Reality: From Theory to Applications) All interactions are energy-dependent and microRNA-mediated. ~250 newly indexed articles attest to that fact, which is…

Read More

God’s microRNA-mediated Creation of genotypes (4)

September 16, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
No Comments

Non-random distribution of individual genetic diversity along an environmental gradient 6/12/09 links the energy-dependent Creation of ecologically relevant phenotypes to pH-dependent biophysically constrained viral latency across kingdoms via single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs). See also:  T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals 9/16/21 …we report on T cell immunity in infected and vaccinated individuals, identifying CD4+/CD8+ T cell cytokine responses to SARS-CoV-2 and variant peptides… Light-activated carbon…

Read More

God’s microRNA-mediated Creation of genotypes (3)

September 11, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity
No Comments

Commentary: Origin and evolution of pathogenic coronaviruses 4/21/20 Both fieldworks and experimental biology are required to understand the viruses concomitantly with predicting or preventing potential outbreaks. On 4/23/20 former President Trump linked God’s Creation of sunlight and humidity to weakened #COVID19 and the end or effective treatment of all virus-driven pathology via RNA interference (#RNAi). See for comparison: Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues  5/25/21 Reported as:…

Read More

God’s microRNA-mediated Creation of genotypes (2)

September 9, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
No Comments

More than 127,000 indexed published works link God’s energy-dependent Creation of microRNAs to all biodiversity via energy-dependent microRNA-mediated DNA supercoiling . See: microRNA See first: God’s microRNA-mediated Creation of genotypes (1) See also: MiR-125b regulates the differentiation of hair follicles in Fine-wool Sheep and Cashmere goats by targeting MXD4 and FGFR2 9/6/21 If you can’t link this to chromosomal rearrangements and sympatric speciation in species from flies to labradoodles, you haven’t played the STEM toy for ages 14+ “Genotype.” One…

Read More

God’s microRNA-mediated Creation of genotypes (1)

September 8, 2021
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
One Comment

See first: Natural selection for adaptation (10) DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition  9/5/21 The bispecific intracellular miRNA controllable DNA circuit…easily extends to various cell type discrimination by adjusting the [energy-dependent biophysically constrained Creation of] miRNA species… When Fauci claimed it was molecularly impossible to engineer SARS-CoV-2 in the Wuhan lab, the extent of his lies became clear. The fact that he lied before Congress is now clearer. See: Learning noncoding RNA…

Read More

Natural selection for adaptation (10)

September 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18 Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications…

Read More

Natural selection for adaptation (9)

September 7, 2021
James Kohl
Adaptations, Diseases & Disorders, Ecology, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
No Comments

“Mapping the dynamic transfer functions of eukaryotic gene regulation” 8/31/21 links energy-dependent changes from angstroms to ecosystems via “Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion“ For review see Lynn Zechiedrich‘s group: “Structural diversity of supercoiled DNA” and the representation of God’s Creation of energy-dependent microRNA-mediated biodiversity in: See also: Chemists Know (10/6/14) Remember to start with Feynman’s claims about food energy. Stop the killing spree! Protect yourself sans synthetic mRNA vaccine-induced pathology. See also: Getting Closer to…

Read More

Natural selection for adaptation (8)

September 2, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
No Comments

Facts about natural selection for adaptation can be compared to theories of Evolution by Gene Duplication (1970) The creation of metazoans, vertebrates and finally mammals from unicellular organisms… required the creation of new gene loci with previously nonexistent functions. The persistent theories of evolution by gene duplication can be compared to facts natural selection for adaptation in the context of God’s Creation of subatomic particles, such as protons and the ATP-dependent creation of RNA, which was required to link the…

Read More
RSS Perfuming the Mind