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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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From optoribogenetics to HelioRiboGenetics (5)

October 6, 2020
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA interference
No Comments

Wen Zhou’s group linked quantum coherence to coherently organized biology via God’s Creation of the sense of smell and the space-time continuum in Olfaction Warps Visual Time Perception Ages 10-14+ can review what is known about God’s Creation of energy-as-information and link it from HelioRiboGenetics and RNA interference to Genotypes via game play of: ION: Covalence Peptide Virulence Subatomic Periodic Cytosis Virus Expansion Ecosystem Genotype (November 2020) Alternatively, see: Announcement of the 2020 Nobel Prize in Physics Reported in Physics…

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From optoribogenetics to HelioRiboGenetics (4)

October 6, 2020
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA interference
No Comments

The 2020 Nobel Laureates in Physiology or Medicine failed to link God’s Creation of energy-as-information in ultraviolet (UV) light and His Creation of water to biophysically constrained viral latency across kingdoms via oxidative phosphorylation and RNA interference. See for comparison: Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers 9/30/20 Conclusion The data indicate that PPMO have the ability to potently and specifically suppress SARS-CoV-2 growth and are promising candidates for further pre-clinical development. If the history of published…

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From optoribogenetics to HelioRiboGenetics (3)

October 6, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA interference
No Comments

See first: From optoribogenetics to HelioRiboGenetics (2) and From optoribogenetics to HelioRiboGenetics (1) “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients Chronic hepatitis C (CHC) evolves in 20% of cases to liver cirrhosis after progressive stages of fibrosis (Center for Diseases Control and Prevention – CDC, 2019). The most serious complication…

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From optoribogenetics to HelioRiboGenetics (2)

October 5, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
One Comment

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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From optoribogenetics to HelioRiboGenetics (1)

October 5, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference
2 Comments

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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Optoribogenetic-driven sympatric speciation (2)

October 4, 2020
James Kohl
Adaptations, Ecology, RNA Directed, RNA interference, Subatomic
No Comments

See the 7-part series: Predicting who wins the 2017 Nobel Prizes (7) Conclusion: The biggest threat to humanity is not the “Big Bang” theory of creation or the “Big Bang” theory of how life on Earth might end after an explosion of cosmic proportions. The biggest threat has always been “human idiocy.” For examples of human idiocy, see anything published by any researcher or any research group that failed to link God’s Creation of UV light and water from oxidative…

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Optoribogenetic-driven sympatric speciation (1)

September 30, 2020
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
No Comments

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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UV light, H2O, and epigenetic effects… (2)

September 27, 2020
James Kohl
Adaptations, Diseases & Disorders, Ecology, Physics, RNA interference
No Comments

UV light, H2O, and epigenetic effects… (1) 9/25/20 During the 9/26/20 “Benghazi and Twin Towers Memorial Ride and Veterans Event” at Band of Brothers Veterans Park in Murphy, North Carolina,  DW (Del) Wilber ( guest speaker and “Counterterrorism Analyst”) reminded me that in 2006, Greg Bear’s Quantico was near future, hard counterterrorism science fiction. Historical perspective:Greg Bear is the author of more than thirty books, spanning thrillers, science fiction, and fantasy, including Blood Music, Eon, The Forge of God, Darwin’s…

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UV light, H2O, and epigenetic effects… (3)

September 26, 2020
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
One Comment

Trump nominates conservative Amy Coney Barrett for Supreme Court She would be the only justice on the current court not to have received her law degree from an Ivy League school. The eight current justices all attended either Harvard or Yale. Most researchers at Harvard and Yale failed to admit, and failed to teach their students, that God’s Creation of UV light and water biophysically constrains viral latency across kingdoms via oxidative phosphorylation. They are being forced to tell the…

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UV light, H2O, and epigenetic effects… (1)

September 25, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
One Comment

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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