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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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The eternal significance of microRNAs (1)

April 10, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Common Allele Linked to Sugar Consumption Leads to Lower Body Fat, Higher Blood Pressure One energy-dependent change in a base pair is linked from the FGF21 rs838133 variant to microRNA-mediated changes in morphology and behavior. The quantized energy as information link from microRNAs to morphology and behavior is common to my mouse-to-human model of sympatric speciation. By linking the common allele to sugar consumption, the authors attest to the fact that sympatric speciation is quantized energy-dependent. Energy as information biophysically constrains…

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Sympatric Speciation vs pseudosceintific nonsense (4)

April 10, 2018
James Kohl
RNA Directed
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The energy-dependent creation of ATP synthase and the energy-dependent creation of the microRNA repertoire have now been linked to biophysically constrained RNA-mediated sympatric speciation via the innate immune system in species from Axolotyls to A. davidianus infected with ranavirus. MicroRNA repertoire and comparative analysis of Andrias davidianus infected with ranavirus using deep sequencing MicroRNA mediated host-pathogen interactions are important in antiviral defense. See: Meet the creature that can regenerate its brain and resist cancer. (video) Identification and characterization of the…

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Sympatric Speciation vs pseudoscientific nonsense (3)

April 7, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Excerpt: The plausibility and ecological validity of Kohl’s Laws in the context of Darwin’s ‘conditions of life’ can be compared to theories about biologically-based cause and effect in the context of species diversity. In mammals, for example, the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. Origin, Evolution, and Loss of Bacterial Small RNAs (April 6, 2018) …we examine cases of sRNA loss and describe how…

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Sympatric speciation vs pseudoscientic nonsense (2)

April 7, 2018
James Kohl
Adaptations, Autophagy, Diseases & Disorders, Ecology, Light Energy
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This is how intermittent fasting protects us from viruses in the context of using stored fat for quantized energy-dependent RNA-mediated DNA repair. Fat cells converted into stem cells can repair any damaged tissues (video 3:48) Some whales use the molecular mechanisms of quantized energy-dependent RNA-mediated DNA repair during their migration, which is when they may not eat anything until after completing their route. See for details: Energy as information and constrained endogenous RNA interference (video 6:46) Feedback loops link quantized…

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Sympatric Speciation vs Pseudoscientific Nonsense (1)

April 7, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary: The “Science Behind the Game” from the cell biology game “Cytosis” supports all claims that clearly link energy-dependent alternative splicings of pre-mRNAs (aka microRNAs) to biophysically constrained viral latency. Game play by ages 10+ establishes the requirement for viral latency in the context of ecological variation and ecological adaptation outside the context of neo-Darwinian pseudoscientific nonsense. Simply put, Darwin presciently placed his “conditions of life” into the current perspective on ecological niche construction and sympatric speciation, which exemplifies ecological…

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Complexity: Routes and Patterns (4)

April 5, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA Directed
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Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors (2015) …the current models are both consistent with available and new experimental data and offer a number of predictions – notably, through revelation of highly constrained residues (Supplementary Data 9–10) – to guide and visualise structure-function analyses of these unusual sensory receptors. No experimental evidence of top-down causation links anything except the quantized energy-dependent creation of enzymes, hormones, and receptors to biophysically constrained viral latency and ecological…

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Is meat protein unhealthy? (2)

April 5, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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See also: Microbiome-Grade DNA Extraction Kits …the thermal and chemical methods effectively lyse the gram-negative organisms and boost their population in the final profile, amplifying the bias. This suggests that all links from food energy-dependent de novo creation of the pheromone-controlled biophysically constrained bull sperm microRNAome have been misinterpreted in the context of virus-driven fescue toxicosis. The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression …the miRNA profile of mature ejaculated sperm may in fact…

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Is meat protein unhealthy? (1)

April 5, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality Reported as: Meat protein is unhealthy, but protein from nuts and seeds is heart smart In the context of everything known about how the creation of anti-entropic virucidal light must be linked to all biodiversity on Earth, watch this ridiculous misrepresentation of the honeybee model organism. Food energy-dependent microRNA-mediated pheromone-controlled biophysically constrained viral latency is portrayed as if visual input was most important. Bee swarms work like…

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What happened to Timothy J. Cunningham?

April 4, 2018
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, RNA editing, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Missing CDC scientist: What happened to Tim Cunningham? Police release new details (video) My comment: He linked racial/ethnic disparities from epigenetically-effected RNA-mediated sex differences to all virus-driven pathology before anyone else did it. His published works clearly refute all neo-Darwinian pseudoscientific nonsense and he also refuted all the claims made by Big Bang cosmologists. See: 1) Racial/ethnic disparities in self-reported short sleep duration among US-born and foreign-born adults 2) Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease…

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Laws of Biology / Rules of Life

April 3, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, Subatomic, What's in the News
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Summary: Slide number 6 clearly states the “Levels of Biological Organization” that the “NSF’s 10 Big Ideas” finally places into the context of what has been known to all serious scientists for more than a century. Simply put, Hugo de Vries definition of mutation (sudden energy jumps) should never have been accepted as anything besides the claim of a biologically uninformed science idiot. Instead, the definition bastardized every aspect of what is now known about biophysically constrained viral latency and…

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RSS Pheromones.com
  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
RSS Perfuming the Mind
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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