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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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microRNA-mediated cures (10)

December 25, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Merry Christmas 2021! Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans. As presciently predicted in Biblical Genesis, the physiology of pheromone-regulated genetic processes is required. That fact has been exemplified in at least 3 different patents, all of which attest…

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microRNA-mediated cures (9)

December 24, 2021
James Kohl
RNA Directed
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Systematic Characterization of MicroRNA Processing Modes in Plants With Parallel Amplification of RNA Ends 12/7/21 links light-activated carbon fixation from the ATP-dependent creation of RNA and Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) to microRNA-mediated cures via this claim: The synthesis of RNA in isolated thymus nuclei is ATP dependent. Moving forward, The two-step process of ovarian follicular growth and maturation in mammals can be compared to…

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microRNA-mediated cures (8)

December 24, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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A clear indicator of what is required to end the SARS-CoV-2 pandemic was published as: Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review) 12/20/21 The pathophysiology of coronavirus disease 2019 (COVID‑19) is mainly dependent on the underlying mechanisms that mediate the entry of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) into the host cells of the various human tissues/organs.…

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microRNA-mediated cures (7)

December 22, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA interference, RNA–Mediated Epigenetic Heredity
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Pharmacogenomics: A road ahead for precision medicine in psychiatry 10/6/21 In this 2017 Precision Medicine Virtual Conference presentation, I linked the National Microbiome Initiative from microbial quorum sensing to the physiology of pheromone-regulated genetic processes of reproduction and endogenous RNA interference (#RNAi) via chromosomal rearrangements in flies from the works of Thomas Hunt Morgan (1910) to sympatric speciation across kingdoms. The chromosomal rearrangements link light-activated carbon fixation to the ATP-dependent creation of RNA and fixation of amino acid substitutions links…

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microRNA-mediated cures (6)

December 16, 2021
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
One Comment

Aaron Siri tweeted this on 12/9/21 “Call to action for all MDs, DOs, and PhDs: If you want the FDA to release the documents submitted by Pfizer to license its Covid V as soon as possible, please join PHMPT right now at Public Health and Medical Professionals for Transparency” Four days after the Pfizer vaccine was approved for ages 16+, we submitted a Freedom of Information Act Request to the FDA for all of the data within Pfizer’s COVID-19 vaccine…

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microRNA-mediated cures (5)

December 13, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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“Dead” nucleotides are biophysically constrained pH-dependent single nucleotide substitutions (SNPs). See first: microRNA-mediated cures (4) Remember what’s been known for decades about dead nucleotides, nucleotide substitutions that are biophysically constrained, when you read about the prevention of bioterrorism and public health fascism in Imagination and remembrance: what role should historical epidemiology play in a world bewitched by mathematical modelling of COVID-19 and other epidemics? 6/7/21 …every established respiratory pandemic of the last 130 years has caused seasonal waves of infection…

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microRNA-mediated cures (4)

December 9, 2021
James Kohl
RNA Directed
One Comment

The link from God’s Creation of sunlight and humidity to the ATP-dependent Creation of RNA was reported in 1964. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” The synthesis of RNA in isolated thymus nuclei is ATP dependent. That fact has been linked to biophysically constrained viral latency across kingdoms at every level of examination by all intelligent serious scientists, since 1964. For example, start with God’s Creation…

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microRNA-mediated cures (3)

December 6, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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See first:  microRNA-mediated cures (2) For comparison to Genetic variations creating microRNA target sites…, and Nutrient-dependent/pheromone-controlled adaptive evolution, Masatoshi Nei claimed that nucleotide substitutions, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, horizontal gene transfer et al., were mutations. Simply put, simple-minded theorists start with the idea that everything the happens to our supercoiled DNA is a mutation and they link mutations to evolution across billions to millions of years after energy-emerged from the…

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microRNA-mediated cures (2)

December 2, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Neuronal Plasticity, Physics, replication timing, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity, What's in the News
One Comment

If you find a recently published article that does not link “How microRNAs control cell division, differentiation and death” (2005) to healthy longevity instead of virus-driven diseases, please share it for comparison to “Advances in Genetics: Chapter One – miRNA, Development and Disease (2012) and Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors (3/15/12). Neo-Darwinian theorists and Big Bang cosmologists desparately need experimental evidence of energy-dependent top-down causation to support their stupid theories, and…

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microRNA-mediated cures (1)

December 1, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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See first: Naturally attenuated viral endemicity (10) All effective cancer therapies and drug therapies are energy-dependent and microRNA-mediated. Princeton team disables long-targeted gene behind spread of major cancers 11/29/21 This discovery has its roots in 2004 research in which Princeton scientists identified a gene implicated in metastatic breast cancer, called metadherin, or MTDH. Prevent obfuscation of facts that link energy-dependent changes in single nucleotide polymorphisms (SNPs) in microRNAs to all effective cancer treatments via the RBP-noncoding RNA regulation network. Read:…

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