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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Natural selection for adaptation (7)

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome 8/31/21 was reported as: High virus count in the lungs drives COVID-19 deaths 8/31/21 …the study revealed that those who died had on average 50 percent lower production of a type of immune chemical that targets the coronavirus compared with the COVID-19 patients who survived the illness. These customized proteins are part of the body’s adaptive immune system, a subset of cells and chemicals…

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Natural selection for adaptation (6)

I’ve published 3 letters to the editor of a local newspaper, The News Observer, during the past 3 weeks. If this is published on September 1, it may be the end of several multi-part series on the eternal significance of microRNAs, which has been linked to microRNA-mediated population control 7/23/21-8/13/21. See also: Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits 8/24/21 The results indicated that during the design of MREs in synthetic gene circuits,…

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Natural selection for adaptation (5)

See first: Natural selection for adaptation (4) If you have not yet linked God’s Creation of energy-as-information from the pH-dependent physiology of reproduction to biophysically constrained viral latency and all phenotypes, start with Regulation of MicroRNAs 8/26/21. For comparison, Charles Darwin invented his theory based on no ability to observe biophysically constrained energy-dependent top-down causation at the molecular level. He bred pigeons, which led him to focus on morphology and link the food that finches ate to beak morphology because…

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Natural selection for adaptation (4)

See first: Natural selection for adaptation (3) See also: “pericentromeric satellite RNA expression” Did you mean “pericentromeric satellite dna expression” No. I am not a stupid gene-centric theorist. I am a Creationist who knows how energy-dependent supercoiled DNA is Created. For instance, light-activated microRNA-mediated “Biogenesis is regulated by many checkpoints at every step, primarily at the transcriptional level, in the nucleus, cytoplasm, with RNA regulation, RISC loading, miRNA strand selection, RNA methylation/uridylation, and turnover rate.” If you have not yet…

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Natural selection for adaptation (3)

See: Natural selection for adaptation (2) Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 8/19/21 Senior author Jean-Laurent Casanova‘s claims have consistently linked energy-dependent biophysically constrained viral latency across kingdoms. They can be linked to prevention of unnecessary suffering and premature COVID-19 deaths via my 10-part series on microRNA-mediated replication. Facts about microRNA-mediated replication were presciently placed into the context of healthy longevity via refutations…

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Natural selection for adaptation (2)

See first: Natural selection for adaptation (1) It’s been 20 days since biologically uninformed science idiots reported everything known to intelligent serious scientists about natural selection for biophysically constrained viral latency and ecologically adapted phenotypes in the context of cryptic transmission. See: Altered chromatin states drive cryptic transcription in aging mammalian stem cells 8/2/21 This nonsense was reported on 8/3/21 as Aging Cells May Lose Control of Where an mRNA Sequence Starts The cell’s machinery ‘reads’ DNA sequences in sets…

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Natural selection for adaptation (1)

My August 12, 2021 tweet made more than 34,000 impressions. That fact was reported on August 18, 2021 after I publicly complained about the delay in making it my “Top Tweet” for the month. My complaint was based on the fact that nearly 126,000 citations to published works mention microRNAs. Each of them attests to facts about natural selection for energy-dependent codon optimality. All intelligent serious scientists know that codon optimality biophysically constrains viral latency and healthy longevity across kingdoms…

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Wars caused by metaphors: 1964

Theorists tend to use metaphors to support their stupid theories. Intelligent serious scientists consistently use facts. For example, researchers from Japan and the USA attacked the Chinese Communist Party’s representations of naturally evolved virus-driven pathology with claims in Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197 6/11/21 …the first example of modulation of activity of endogenous noncoding RNA using M-modified triplex-forming PNA. It is clear that peptide synthesis at the origin of life is linked from biophysically…

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MicroRNA-mediated population control (10)

32694 impressions in 1 day. 8/12/21 Virus-driven degradation of mRNA has been linked to all pathology & microRNA-mediated DNA repair links oxidative phosphorylation to the stability of all organized genomes via natural selection for energy-dependent codon optimality and God’s microRNA-mediated stem cell Creation. Researchers who understand energy-dependent cell type Creation are moving forward with facts that refute all the stupid theories touted by neo-Darwinists and Big Bang cosmologists. See: Deciphering epigenetic(s) role in modulating susceptibility to and severity of COVID-19…

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MicroRNA-mediated population control (9)

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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