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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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pH-dependent viral latency (5)

June 5, 2020
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Nutrigenomics, RNA Directed, RNA interference, What's in the News
One Comment

Molecular and biochemical mechanisms of human iris color: A comprehensive review 6/2/20 MicroRNAs also affect melanocyte synthesis, which is usually affected by the downregulation of essential genes involved in pigmentation. Researchers from Iran linked light-activated microRNA biogenesis in plants to the expression genes that effect the number, size and/or the pH of pathways that influence melanin synthesis in the context of human iris color and human skin pigmentation via the L‐tyrosine amino acid precursor. The energy-dependent microRNA-mediated link from the…

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pH-dependent viral latency (4)

May 29, 2020
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA interference
No Comments

My top tweet @microRNApro during the month of March 2018 earned 3,884 impressions. I wrote: See also my series on “Interethnic biodiversity” via this search: Interethnic genetic simiarities and a PubMed search for microRNA See also: Denying Genetics Isn’t Shutting Down Racism, It’s Fueling It 3/30/18 On the male-female divide, for example, Reich cites profound differences, “reflecting more than 100 million years of evolution and adaptation.” On race, he is both agnostic about what we will eventually find out with respect…

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pH-dependent viral latency (3)

May 25, 2020
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference
No Comments

Most Memorial Day 2020 celebrations and services were cancelled due to the well-orchestrated coronavirus crisis, which led to restrictions on our Constitutional rights. During the past two years, I’ve linked the eternal significance of light-activated microRNA biogenesis to our Constitutional rights. See the 10-part series: The eternal significance of microRNAs (10) and the 10-part series: The microRNA-mediated future of humanity (10) See also: pH-dependent viral latency and pH-dependent viral latency (2) Ages 10-14+ can learn what is known about pH-dependent…

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pH-dependent viral latency (2)

May 24, 2020
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, What's in the News
No Comments

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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pH-dependent viral latency (1)

May 22, 2020
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference
One Comment

Four back-to-back articles in Science Magazine on May 15, 2020 attest to facts about how God’s Creation of energy-as-information was linked to all biodiversity on Earth via President Donald J. Trump’s claim about UV light and facts about light activated microRNA biogenesis, which biophysically constrains viral latency via the pH-dependent physiology of reproduction.   1) Modeling infectious disease dynamics The current pandemic has no parallel…, but the new virus is following rules common to other pathogens. The so-called “rules” are…

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The tipping point (revisited): 102K (1)

May 15, 2020
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference, RNA-mediated gene silencing
No Comments

See first:  The tipping point (revisited): 101K (1) 4/22/20 and Vaccines do not control pandemics (1) 5/15/20 Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion 5/11/20 They linked virus-driven changes in light-activated energy-dependent differences in hydrogen-atom transfer in DNA base pairs in solution from microRNA flanking sequences to the degradation of messenger RNA and all obesity-linked diseases via changes in the potential of hydrogen (pH). See: Control of pH responsive peptide self-association…

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Vaccines do not control pandemics (1)

May 15, 2020
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA interference, Subatomic
2 Comments

See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/16/18 Compared to the G2 RotaTeq vaccine strain, 17-24 amino acid changes, specifically A87T, D96N, S213D, and S242N substitutions in G2 epitopes, were observed. Amino acid changes control pandemics. Congo: MSF Ebola vaccination begins 5/30/18 The Ebola vaccine (rVSVDG-ZEBOV-GP) is being used as part of the overall strategy to control the Ebola outbreak. There was no indication that the vaccine strategy…

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The microRNA-mediated future of humanity (8)

May 8, 2020
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, Subatomic, Variations
No Comments

The levels of complexity linked to the microRNA-mediated future of humanity can be examined by ages 10-14+ via game-play of: Bacillus (failed project) See instead: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana 10/17/19 Peptide Players compete to link amino acids to build a peptide chain (a fancy word for a protein). Virulence Players take on the role of viruses and compete to infect a host cell in…

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The microRNA-mediated future of humanity (7)

May 6, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference
No Comments

Until recently, particle physics could not be linked to coherently organized biology by arbitrarily large energies. But KB Whaley and others have linked quantum coherence to high energy completion and President Donald J. Trump’s claims about effective coronavirus treatment with remdesivir. See also: INDY inhibition attenuates diet-induced NASH  (March 2020) Conserved molecular mechanisms link the light-activated assembly of the microRNA-RNA-peptide nanocomplex from the plasma-membrane tricarboxylate transporter INDY (I’m Not Dead Yet) to effective treatment of coronavirus pathology with remdesivir. If…

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The microRNA-mediated future of humanity (5)

May 1, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA interference, Subatomic, Variations
No Comments

Coronavirus facts from Scientific Creationists in South Korea (reported as a coronavirus tip to Business Insider on 5/1/2020) Re: “South Korea says recovered coronavirus patients who tested positive again did not relapse: Tests picked up ‘dead virus fragments’ Summary: Scientists from the so-called “Creationist Capital of the World” linked inaccurate test results to the end of the ongoing well-orchestrated coronavirus crisis. They also linked President Trump’s claims about UV light-activated microRNA biogenesis to protection from stress-linked virus-driven pathology in all…

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