A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation Excerpt (with my emphasis): Highlights • A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed. • Dynamics and replication timing of Xi were visualized. • Critical amino acids for the stability and/or folding of the mintbody were revealed. Reported as: Catching histones by the tail: A … Chromatin: The structure of DNA (2)
See: Chromatin: The structure of DNA (2) Inherited parental methylation shifts over time, may have functional effects in the brain and other tissues Excerpt: …researchers have theorized that inherited methylation, also referred to as parental imprinting, largely remains stable throughout development, except during two important developmental milestones: after fertilization and during the creation of sperm … Chromatin: The structure of DNA (3)
Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how … Chromatin: The structure of DNA
Initiating DNA repair To communicate stress signals within cells, JNKs add phosphate groups to proteins, and the Rochester study found the amino acid residue on SIRT6 that is modified by JNK. They found an energy-dependent RNA-mediated amino acid substitution linked to the physiology of reproduction. It makes DNA repair and transgenerational epigentic inheritance of biologically-based … DNA repair via junk DNA (1)
Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice Excerpt: Our findings suggest that m6A is regulated in an activity-dependent manner in the adult brain, and may function to fine-tune mRNA turnover during memory-related processes. My comment: They cite: Alarcón CR, Lee H, Goodarzi H, Halberg N, … RNA methylation, learning, memory and behavior,
Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus Several studies have provided evidence suggesting that “placebo effects” represent conditioning phenomena and that learning processes influence the response to placebo medication. This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose … RNA methylation (2)
This is a brief history of events that led me to found the domain RNA-mediated.com with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the … RNA methylation
Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016) My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must … RNA methylation, behavior, and disease
Epigenetics and How Our Decisions Affect Our DNA Excerpt (with my emphasis): With the Genetics and Genomics 2016 virtual conference now on demand, we are extending the genetics conversation into this month with a new infographic. Epigenetics has been in the news quite a bit lately as researchers have been able to learn more about … Energy-dependent RNA methylation (9)
Plexciton Dirac points and topological modes Reported as: Scientists design energy-carrying particles called ‘topological plexcitons’ Excerpt: This should eventually enable engineers to create plexcitonic switches to distribute energy selectively across different components of a new kind of solar cell or light-harvesting device. My comment: “Single-residue insertion switches the quaternary structure and exciton states of cryptophyte … Energy-dependent RNA methylation (10)
