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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Photonics in Forensics (7)

March 10, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Living with the Neanderthals 8/14/03 …Bear pleads for biologists to write clearly: “Don’t they realize how important it is to get the word out to everybody?” Social media censorship prevents people from learning the facts. All intelligent serious scientists and many intelligent people know that sunlight is beneficial in the context of biophotonics and forensics In the context of coronavirus pathology, this was stated clearly as US government experiments with simulations to show the coronavirus can ‘quickly’ be destroyed by…

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Photonics in Forensics (6)

March 4, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic
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The alphavirus 3′-nontranslated region: size heterogeneity and arrangement of repeated sequence elements 1/5/98 The 19-nt conserved sequence element directly adjacent to the poly(A) tract was found in all viruses The 19-nt conserved sequence element is biophysically constrained across kingdoms. No experimental evidence of top-down energy-dependent causation suggests that this 19-nt conserved sequence evolved via natural selection for mutations during billions to millions of years. For comparison, the conservation of one 22-nucleotide ring was reported in Footprints of a Singular 22-Nucleotide…

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Photonics in Forensics (5)

March 1, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Forensics: a laboratory or department responsible for tests used in detection of crime, especially the crimes committed by corrupt politicians. Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21 However, the strength of this mechanism during embryogenesis, as well as its relationship with other known regulatory elements, such as microRNA, remains unclear. God’s Creation of sunlight and humidity biophysically constrains the pH-dependent crosstalk via oxidative phosphorylation and stem cell creation. That fact about microRNAs is perfectly clear. See:…

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Peptide synthesis and therapy update 2/28/22

February 28, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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I just discovered the URL I used for Peptide synthesis at the origin of life has changed from what I initially reported in more than 100 different blog posts. That could make it more difficult for most people to link peptide synthesis to the origin of information and to peptide therapy via Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20, which was published two days after former President Trump linked God’s Creation of sunlight and…

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Photonics in Forensics (4)

February 24, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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See first: Photonics in Forensics (3) MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position 2/22/22 ….the two 3′-binding modes both appear to be compatible with either of the two gene-regulatory  processes that involve 3′ pairing—TDMD (target-directed miRNA degradation (TDMD) and miRNA-mediated repression. All metabolic disease processes are microRNA-mediated see: microRNA 136,017 results and this 2/23/22 indexed adddition:”Spatially Resolved, Error-Robust Multiplexed MicroRNA Profiling in Single Living Cells” 2/22/22 The FluoELs enabled a single-cell…

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Photonics in Forensics (3)

February 23, 2022
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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On 2/22/22, I was able to reach many more stupid theorists than usual with one tweet, which was based on publication of: MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position 2/22/22 ….the two 3′-binding modes both appear to be compatible with either of the two gene-regulatory processes that involve 3′ pairing—TDMD (target-directed miRNA degradation (TDMD) and miRNA-mediated repression. In my model, all gene regulatory processes are energy-dependent and “MicroRNAs organize intrinsic variation…

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Photonics in Forensics (2)

February 22, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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MicroRNAs have been linked to the cause and/or the effective light-activated treatment of all virus-driven pathology in nearly 136,000 indexed published works. See: microRNA Use Meniere’s as an example: See: Distinct MicroRNA Profiles in the Perilymph and Serum of Patients With Menière’s Disease 6/16/21 See also: MicroRNA Profiling as a Methodology to Diagnose Ménière’s Disease: Potential Application of Machine Learning 7/14/20 On 2/20/22 I reported in microRNA-mediated biodiversity (10) that data from three databases linked former President Trump’s 4/23/20 claim…

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Photonics in Forensics (1)

February 21, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Effective 2/20/22, 135,840 results from a search of PubMed for “microRNAs” includes this article: MiRLoc: predicting miRNA subcellular localization by incorporating miRNA-mRNA interactions and mRNA subcellular localization …results show that miRNA functional similarity data can be effectively used to predict miRNA subcellular localization… Intelligent serious scientists know the claim about microRNA-mediated subcellular localization and functional similarity eliminates all the claims made by gene-centric theorists, since the time they started inventing their stupid theories. But wait, there’s more! For a historical…

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microRNA-mediated biodiversity (10)

February 20, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
2 Comments

“Barrage of disconnected posts” Sound familiar? Should be like looking in a mirror for you. 2/20/22 @ppchuman, @JikkyKjj, and @B3H3ALTHY are among the anonymous fools, biologically uninformed science idiots, and killer clowns such as @RNAsucks, who failed to link light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and healthy longevity via energy-dependent epigenetic effects on gene sequences and RNA interference (#RNAi), which I detailed in my model. There is no other model of naturally occurring biophysically constrained pH-dependent…

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microRNA-mediated biodiversity (9)

February 20, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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microRNA (miR-KT-635) encoded by Cyprinid herpesvirus 2 regulates the viral replication with targeting to the ORF23 (2/19/22) has been linked to the patented cure for all virus-driven diseases across kingdoms via Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency (2/8/22) Who, besides our NIH Director, Lawrence A. Tabak and former President Trump is not surprised to see that researchers from Harvard collaborated with researchers from China to obfuscate the facts from the patent for…

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