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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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microRNA-mediated replication timing (5)

Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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microRNA-mediated replication timing (4)

See first: microRNA-mediated replication timing (1) 6/17/21 microRNA-mediated replication timing (2) 6/27/21 microRNA-mediated replication timing (3) 6/29/21 Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome 1/15/21 was reported on 6/29/21 as Study provides first genome-wide evidence for functional importance of unusual DNA structures Some regions of the human genome where the DNA can fold into unusual three-dimensional structures called c (G4s) show signs that they are preserved by natural selection. The…

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microRNA-mediated replication timing (3)

miRNAs; a novel strategy for the treatment of COVID-19 6/28/21 Several previous studies have shown that host miRNAs play an anti-viral role and improve the treatment of patients with COVID-19. miRNAs by binding to the 3′-UTR or 5′-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. That fact makes it easier to convict Facebook of crimes against humanity because their censors prevent me from including links to autophagy.pro, and to microRNA.pro which expose the scientific…

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microRNA-mediated replication timing (2)

Transcription typically requires the energy-dependent Creation of the enzyme RNA polymerase. Intelligent serious scientists know that enzymes do not automagically create themselves, and most of them realize that transcription began when God Created the anti-entropic virucidal energy of sunlight. The 6/4/21 cover of Science Magazine, places that fact about biophysically constrained transcription into the context of pH-dependent oxidative phosphorylation. However, McEwen et al’s claims from 1964 are not included in the content from “Structures of the human Mediator and Mediator-bound…

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microRNA-mediated replication timing (1)

The phylogenetic utility and functional constraint of microRNA flanking sequences links the patent for naturally occurring light-activated carbon fixation to viral latency and healthy longevity across kingdoms. The patent: RNA-Guided Human Genome Engineering was linked from functional constraints to gain-of-function research in High-Quality Overlapping Paired-End Reads for the Detection of A-to-I Editing on Small RNA WHO failed to examine the problems associated with gain-of-function research, which researchers now suggest led to the creation of SARs-CoV-2. The creation of SARs-CoV-2 can be…

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Light-activated carbon fixation did not evolve (5)

See first: The tipping point (revisited): 120K 5/12/21 Church Speaks: The cyanobacteria fix [carbon via] light…Under ideal circumstances, they can be maybe seven to ten times more productive per photon.” George M. Church et al patented this naturally occurring process. On 5/12/21, I was pleasantly surprised to see the facts represented in this trail-side placard at Canyonlands National Park. The facts make this patent worthless: RNA-Guided Human Genome Engineering See why: Light-activated binding together of sand and other soil particles…

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Quantum biology vs atheism (2)

One year ago, on 4/23/20 former President Donald J. Trump linked sunlight and humidity to weakened Covid-19 via everything known to intelligent serious scientists about light-activated microRNA biogenesis, RNA interference, and biophysically constrained viral latency across kingdoms. On 4/24/20 Jonathan Reiner, professor of medicine at The George Washington University Hospital, said there’s no medical basis for Trump’s statements about sunlight. God’s Creation of sunlight and humidity were linked across kingdoms from Cascade diversification directs generation of neuronal diversity in the…

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Quantum biology vs atheism (1)

Peptide synthesis at the origin of life links quantum coherence to coherently organized biology via biophysically constrained viral latency. See: Identification of a micropeptide and multiple secondary cell genes that modulate Drosophila male reproductive success 4/13/21 A noncoding RNA generates amino acid peptides and energy-dependent sperm-competition phenotypes. Moving forward across species, see: Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy‐related diseases 4/20/21 Circular RNAs (circRNAs) are endogenous noncoding RNAs with unique cyclic structures. Although they were previously considered…

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Quantum Darwinism (10)

Evolution after whole genome duplication: teleost microRNAs 4/19/21 …provides the first genome-wide, multi-species analysis of the mechanisms influencing metazoan miRNA evolution after whole genome duplication. Shows that energy must be linked from biophysically constrained viral latency to ecological adaptations. For other refutations of neo-Darwinian pseudoscietific nonsense follow the scientific progress via a search for microRNA as the number of indexed publications continues to rise at a rate of 1000+ each month. For a recent obfuscation of facts in a curated…

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Quantum Darwinism (9)

Beyond the Elements: Life (video with transcript) There was a turning point, the evolution of a transformative series of chemical reactions that, over time, remade the planet… They place God’s Creation of sunlight and humidity at the origin of life (THE turning point) into the context of experimental evidence of enzyme-dependent directed evolution, which requires this stupid assumption from 2005. “Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.” Enzymes are proteins. No experimental evidence of…

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