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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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The eternal significance of microRNAs (4)

April 20, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Light Energy, microRNA editing, Model Organisms, RNA Directed
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Conclusion: Conserved energy biophysically constrains viral latency. Metatranscriptomics High-throughput sequencing and analysis of microbial community cDNA are providing valuable insight into in situ microbial activity and metabolism in the oceans. When faced with the eternal significance of quantized energy-dependent natural selection for codon optimality, theorists must attack the basics of what is known to serious scientists about biophysically constrained life on Earth. See for example: Virus-mediated archaeal hecatomb in the deep seafloor By starting with “raw assemblies” instead of the…

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Abiogenesis vs microRNA biogenesis (3)

April 20, 2018
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Reappraising the human mitochondrial DNA recombination dogma   My comment to BioRxiv (Hold on, this is waiting to be approved by BioRxiv) Thank you for helping to show what has been missing from neo-Darwinian theories and other claims that were based on de Vries 1902 definition of mutation. Theorists may now want to learn more about the energy-dependent molecular mechanisms of recombination. Most of them will not like the findings you have provided. The peer-review process is especially deadly to…

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For God and Country

Abiogenesis vs microRNA biogenesis (2)

April 20, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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All serious scientists learned about Schrödinger’s claims in “What is Life?” (1944).  All serious scientists have since linked the creation of the sun’s anti-entropic virucidal energy to “negentropy” and healthy longevity. See also: Reappraising the human mitochondrial DNA recombination dogma …paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.   Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction. See the works of those who are scheduled to present during Schrödinger at…

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Abiogenesis vs microRNA biogenesis

April 18, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories. See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group: ——————————- Abiogenesis (2017) Microscopic dissipative structuring and proliferation at the origin of life (Oct 13, 2017) Some fundamental molecules…

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2018 March for Science vs microRNAs (2)

April 18, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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The anti-entropic virucidal energy of sunlight on contact with water has been linked from the creation of ATP synthase to the creation of ATP and to the creation of RNA. Energy-dependent RNA-mediated DNA repair has been linked to biophysically constrained viral latency via the creation of microRNAs and feedback loops linked to the food energy-dependent microRNA-mediated physiology of reproduction. The physiology of energy-dependent pheromone-controlled reproduction biophysically constrains viral latency in the context of the creation of the innate immune system…

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2018 March for Science vs microRNAs

April 17, 2018
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, RNA Directed
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Summary: Only biologically uninformed theorists and other pseudoscientists do not seem to know that all carbon-based life is quantized energy-dependent and that biophotonic energy as information comes from the sun. It is obvious to all serious scientists that proton gradients link photons from quantized energy as information to the proton motive force, which is how the potential of hydrogen (pH) is linked to changes in the microRNA/messenger RNA balance that biophysically constrain viral latency in the context of hydrogen-atom transfer…

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An evolutionary theory killer

The eternal significance of microRNAs (3)

April 13, 2018
James Kohl
Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary:  RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong.   I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. When trapped by their ridiculous theories, they no longer kick, scream, or bite (like weasels). They participate in so-called marches like the 2018 March for…

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The eternal significance of microRNAs (2)

April 12, 2018
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril. The Immune Landscape of Cancer (2018) Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune…

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The eternal significance of microRNAs (1) – revisited

April 11, 2018
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology
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I have never been forced to revisit a blog post on the day after it was posted, until now. The Scientist has misrepresented everything known to all serious scientists about the eternal significance of microRNAs in: Sweet Tooth Gene Tied to Less Body Fat “These results suggest that FGF21 has pleiotropic effects, with separate effects on macronutrient intake to those on body shape and blood pressure,” the authors write in their report. My comment to The Scientist See All About…

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The eternal significance of microRNAs (1)

April 10, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Common Allele Linked to Sugar Consumption Leads to Lower Body Fat, Higher Blood Pressure One energy-dependent change in a base pair is linked from the FGF21 rs838133 variant to microRNA-mediated changes in morphology and behavior. The quantized energy as information link from microRNAs to morphology and behavior is common to my mouse-to-human model of sympatric speciation. By linking the common allele to sugar consumption, the authors attest to the fact that sympatric speciation is quantized energy-dependent. Energy as information biophysically constrains…

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