Molecular and biochemical mechanisms of human iris color: A comprehensive review 6/2/20

MicroRNAs also affect melanocyte synthesis, which is usually affected by the downregulation of essential genes involved in pigmentation.

Researchers from Iran linked light-activated microRNA biogenesis in plants to the expression genes that effect the number, size and/or the pH of pathways that influence melanin synthesis in the context of human iris color and human skin pigmentation via the L‐tyrosine amino acid precursor.

The energy-dependent microRNA-mediated link from the pH of pathways to the amino acid precursor can now be placed into the context of this question, which was previously asked by researchers from Iran:  Why have microRNA biomarkers not been translated from bench to clinic? 1/17/19

More than 1800 human hemoglobin variants link light-activated microRNA biogenesis in plants from the food humans eat to the pheromone-regulated genetic processes of ethnic diversity.

See: HbVar: A Database of Human Hemoglobin Variants and Thalassemias

How many more examples of how human biodiversity arose do you need when all of them are nutrient-dependent and biophysically constrained by the physiology of reproduction that links them to the human hemoglobin variants?

See also:  Ignoring light-activated microRNA biogenesis 10/16/18

He frames his claims in the context of random mutations and evolved biodiversity despite the facts that serious scientists have detailed. For example, ages 10+ can learn how the creation of subatomic particles must be linked from cytosis to biophysically constrained viral latency and sympatric speciation.

The physiology of reproduction is linked to heredity in species from soil bacteria to humans via EDAR V370A (an amino acid substitution) in mice; in populations found in North and East Asia; and in populations in the New World.

I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. Alternatively, you could see the work that was published today: “MicroRNAs buffer genetic variation at specific temperatures during embryonic development” for comparison to our 1996 review of molecular epigenetics: “From Fertilization to Adult Sexual Behavior

See also: A novel microRNA, SlymiR208, promotes leaf senescence via regulating cytokinin biosynthesis in tomato 1/27/20

…SlymiR208 is a positive regulator in leaf senescence through negatively regulating CK biosynthesis via targeting SlIPT2 and SlIPT4 in tomato. This study indicated that post-transcriptional regulation via miRNA is a control point of CK biosynthesis and added a new layer to the understanding of the regulation of CK biosynthesis in tomato and a new factual proof to support that miRNAs are involved in leaf senescence.

Reported on 6/4/20 as:  Another thread in the tangled knot of leaf senescence

…Zhang et al. (2020) describes the way in which a novel microRNA (miRNA) affects the timing of leaf senescence in tomato (Solanum lycopersicum) by modulating biosynthesis of the phytohormone cytokinin.

Everyone who failed to link

1) light-activated microRNA biogenesis from changes in plant growth and

2) changes in the food energy-dependent pheromone-controlled stability of the amino acid substitution, EDARV370A in human populations and

3) more than 1800 human hemoglobin variants linked to ethnic diversity can now be blamed for the racism and riots that are currently occurring all over the world.

Look for the slogan “Black Lives Matter” and ask who ever claimed that they didn’t.

See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experiencedependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

Most people, especially those who parrot the “Black Lives Matter” motto, failed to learn that they were being played for fools in the context of the coronavirus/COVID-19 crisis for comparison to what is known about the end of the 1918 Spanish influenza pandemic.

See: A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission (2007).

The differences in amino acid changes are also linked to variations in contagion rates and the severity of coronaviruses linked to ethnic diversity. Who doesn’t know that?

Francis S. Collins, the USA’s director of the National Institutes of Health has since sided with the Chinese in the context of A Mouse Model of SARS-CoV-2 Infection and Pathogenesis 5/27/20

Something has gone horribly wrong, because this notice was published on 5/27/20 NIH releases strategic plan to accelerate nutrition research over next 10 years, which is when I learned that George M. Church collaborated with scientific creationists from Korea in Korean Genome Project: 1094 Korean personal genomes with clinical information 5/27/20

It’s as if Francis S. Collins and other stupid neo-Darwinian evolutionary theorists think they can have their cake and eat it, too. But see, Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

Food energy-dependent pheromone-controlled biophysically constrained RNA interference places the “Dawn of Creation” into the context of 5-6,000 years of ecological adaptations, not millions of years of theistic evolution.

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