The Origin of Species (1859) linked the observations of Charles Darwin from his “conditions of life” to all biodiversity on Earth via the physiology of reproduction in all species. Scientific progress across disciplines has since linked his claims to an effective treatment, protonated RNA interference, for virus-driven pathology.
Our recent neutron crystallographic study of the ligand-free SARS-CoV-2 Mpro provided direct visualization of hydrogen (H) atom locations and hydrogen bonding interactions throughout the enzyme.
The authors linked God’s Creation of hydrogen and water to the pH-dependent creation of the enzyme.
See for review:
See for a historical perspective: Unusual zwitterionic catalytic site of SARS-CoV-2 main protease revealed by neutron crystallography 10/15/20
We have successfully determined the neutron structure of the ligand-free SARS–CoV-2 3CL Mpro at near-physiological (room) temperature and pH and mapped the locations of hydrogen atoms (observed as deuterium) in the enzyme. Thus, protonation states and electrical charges of the ionizable residues have been accurately resolved. Establishing the electrostatics in the enzyme active-site cavity and at the dimer interface is critical information to guide the structure-assisted and computational drug design of protease inhibitors, specifically targeting the enzyme from SARS–CoV-2.
The ability to observe how light-activated carbon fixation and pH-dependent effects on the creation of enzymes were linked to the creation of peptides was placed into the context of: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike 4/10/19
…peptide OC43-HR2P, derived from the HR2 domain of HCoV-OC43, exhibited broad fusion inhibitory activity against multiple HCoVs.
Former President Donald J. Trump placed that claim into the context of his 4/23/20 claim that sunlight and humidity weakened coronavirus pathology via Peptide synthesis at the origin of life 11/13/20.
Intelligent serious scientists know why people like Jonathan Reiner make such ridiculous claims. The Bayh-Dole Act of 1980 encouraged universities to patent discoveries, which were funded by taxpayers. It led to the patent for naturally occurring light-activated carbon fixation and prevention/effective treatment of all virus-driven diseases via protonated RNA interference (RNAi).
Like other government-funded academics, Jonathan Reiner is ‘paid’ to tout pseudoscientific nonsense. He has competing interests, whether or not he admits it.
See for comparison this game series for ages 8-14+ The series starts with God’s Creation of sunlight and humidity, which is the only obvious link to all pH-dependent biodiversity on Earth via the physiology of reproduction.
In all the STEM toys, including Genotype, which was also a publicly funded project, the works of Thomas Hunt Morgan were linked to chromosomal rearrangements and sympatric speciation across kingdoms as detailed in the context of Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13
…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.
More than 117,700 indexed publications mention ‘microRNA.’
Light-activated carbon fixation has been linked from the assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and healthy longevity via chromosomal rearrangements in species from microbes to humans.
Most winners of the Thomas Hunt Morgan medal are likely to attest to the fact that nutrient-dependent pheromone-regulated genetic processes link biophysically constrained viral latency across kingdoms to microRNA-mediated chromosomal rearrangements.
Masatoshi Nei may be an exception.
Nei’s work on genetic distances began with an American Naturalist article in 1972. He presented an elegant statistic involving allele frequencies from two populations that, under the infinite alleles mutation model, had an expected value proportional to the time since those populations had diverged from an ancestral population.
Statistical analyses have consistently obfuscated the facts about biophysically constrained viral latency that were linked from chromosomal rearrangements and sympatric speciation in flies by Thomas Hunt Morgan to all genotypes.
Works by Nei, and others who failed to start with God’s Creation of energy bastardized the Darwin’s claims about “conditions of life” and led atheists to ignore the facts that linked chromosomal rearrangements to the “conditions of life.”
Atheists who were taught to believe in stupid theories never recovered enough of their lost intellect to understand this representation of facts, which refuted the claims in Masatoshi Nei’s textbook Mutation-driven evolution. The facts were published on the same day as the textbook length pseudoscientific nonsense.
See also: We are all mutants 3/16/14
For comparison, see the patent for RNA-Guided Human Genome Engineering (2016) and facts about Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20
Something has gone horribly wrong since McEwen et al., 1964 published: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
How did pseudoscientists get from that fact to support for their stupid theories of natural selection for beneficial mutations and evolved biodiversity across billions to millions of years?
Did biologically uninformed science idiots like PZ Myers and his idiot minions manage to limit the curiosity of intelligent people?
See: One crank dies, another rises to take his place 1/6/14
He had a “scientific” theory, which was his, which he thought explained all that evolutionary change while refuting those silly scientists who believed that mutations occurred. No! Evolution was all due to chromosome rearrangements, which somehow are not mutations, and he also somehow ignored the existence of allelic differences between species…
Allelic differences between and among species are nutrient-dependent and pheromone-regulated genetic processes link chromosomal rearrangements to the stability of organized genomes. All intelligent serious scientists know this.
See for comparison: Criticisms of the nutrient-dependent pheromone-controlled evolutionary model 6/4/14
Based on his writings, both published and unpublished, James Kohl presents an unsupported challenge to modern evolutionary theory and misrepresentations of established scientific terms and others’ research. It was a mistake to let such a sloppy review through to be published.
Andrew Jones, BA
The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had been accepted by both reviewers.
For comparison, see: Sexual selection affects the evolution of physiological and life history traits 3/23/21
Don’t wait to ridicule J. Michael Bailey (owner/dictator at “SexNet”) and other so-called sex researchers who have refused to allow discussion of the science of sexual differentiation for ~2.5 decades.
The management of curiosity-driven science for profit delayed the energy-dependent microRNA-mediated effective treatment and/or cure for all virus-driven diseases: protonated RNAi.
And, Watch: Microrobots fight brain tumors in mice. 3/24/20
It recapitulates the claims made in the sci-fi novel “Blood Music” (1985) by Greg Bear which led to his claims about pheromone-regulated genetic processes in a new human species.
See for review of “Darwin’s Radio:” Evolution rising from the grave
Reactivation of a dormant message signals the dawn of a new humanity.
See for review of “Darwin’s Children:” Living with the Neanderthals
He also seeks to teach readers about science, to highlight our utilitarian politics and our inability to get along with each other, and to provide a quasi-rational basis for theology and morality.