It may be a form of insanity that prevents theorists, atheists, and Communists from addressing the facts that have been detailed in the context of: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21

…a class of agents called covalent peptidomimetic inhibitors that work by using strings of unnatural amino acids to bind to specific target proteins.

See for instance:  A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission 2/3/07

Happy Easter!

See also: The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review 3/31/21

Thirteen miRNAs were identified by four independent studies to target SARS-CoV-2 specific genes, suggested to act by interfering with their cleavage and/or translation process. The studies selected also reported on viral and host miRNAs that targeted host genes, on the expression levels of miRNAs in biological specimens of COVID-19 patients, and on the impact of viral genome mutations on miRNA function. Also, miRNAs that regulate the expression levels of the ACE2 and TMPRSS2 proteins, which are critical for the virus entrance in the host cells, were reported.

They linked God’s Creation of anti-entropic virucidal energy and humidity to biophysically constrained viral latency via pH-dependent microRNA-mediated fixation of amino acid substitutions in the context of the patent for naturally occurring light-activated carbon fixation, which prevents the virus-driven degradation of messenger RNA and mutations that cause all diseases.

See the patent: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

On 4/24/21 for a cost of $99-150, you can see:  Immune Dysfunction: Viral Causes, Impact, and Ways to Mitigate Risk

Course description:

This course helps clinicians understand how common viral infections can have long-term consequences carried out by the immune system. You will learn how lytic (actively replicating) and latent (quiescent) viral infections can raise the risk of autoimmune conditions, cancers, myocardial infarctions, and stroke. We will outline how to assess patient risk, and understand the current limitations of laboratory measures. You will understand how to intervene with specific nutrients and bioactives such as pro-resolving mediators, probiotics, and phytochemicals to modulate the immune response. You will learn from case examples what treatment implementation looks like in the real world, including challenges to managing postviral syndromes.

See for comparison: Energy as information and constrained endogenous RNA interference (4) from the 2017 LabRoots virtual conference on Precision Medicine. 

Photosynthesis links the creation of G protein-coupled receptor genes from the innate immune system to nutritional epigenetics and autophagy.

pH-taxis, chemotaxis, thermotaxis and phototaxis link microRNA biogenesis and microRNA flanking sequences from hydrogen energy-dependent changes in the microRNA/messenger RNA balance to autophagy.

Most pseudoscientists, Democrats, liberals, government subsidized academics, Communists, conspiracy theorists and other atheists, have not placed pH-taxis, chemotaxis, thermotaxis and phototaxis into the context of how sunlight and humidity link God’s Creation of energy-as-information to RNA interference across kingdoms. Their ignorance is exemplified in the corruption that former President Donald J. Trump revealed on 4/23/20 when he claimed that sunlight and humidity can weaken the coronavirus.

On 4/24/20 “Jonathan Reiner, professor of medicine at The George Washington University Hospital, said there’s no medical basis for Trump’s statements about sunlight.

Where does he think the phytochemicals that modulate the immune response come from?

See for comparison: Non-canonical ago loading of EV-derived exogenous single stranded miRNA in recipient cells 3/30/21 with specific mention that:

“…release of internalized miRNAs occurs in a pH-dependent manner…”

Also, God’s energy-dependent, (ATP-dependent) pH-dependent, Creation of RNA interference (#RNAi), which biophysically constrains viral latency, has been visualized.

See: Proton regulator of essential cancer microRNA 10/27/20

New findings unveil that a ‘hidden’ layer of regulation by which the intrinsic dynamic ensemble of miRNA processing intermediates can direct the outcome of important biological processes in response to environmental and cellular stimuli in the absence of protein factors.

The so called hidden layer clearly involves the light-activated assembly of the microRNA-RNA-peptide nanocomplex, which links peptide synthesis at the origin of life (11/13/20) to the definition of biophysically constrained energy-dependent life.

Thanks to Guenther Witzany for placing this into the proper context of what life is via “What is Life?” 3/18/20 for comparison to speculation by stupid theorists that chemical metabolism could exist before the Creation of ATP and enzymes.

Do you believe that “Life’s biochemical networks could have formed spontaneously on Earth” (3/3/19) If so, stop reading my blog posts. You are too stupid to understand biologically-based cause and effect.

See also: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography

Stop SARS-CoV-2. Stop cancer. Stop all virus-driven diseases by stopping the stupid theorists. Alternatively, suffer unnecessarily and die prematurely due to ignorance, Communism and atheism.

But wait, there’s more. See: Micro-RNA: The darkhorse of cancer 3/27/21

…we summarize the literature on these master regulators in clinical settings from last three decades…

See my summary in the 10-part series: The eternal significance of microRNAs (4/10/18 until 5/16/18)

The virus-driven degradation of mRNA links the ‘darkhorse’ of cancer to all virus-driven diseases. microRNA biogenesis links the patent for naturally occurring light activated carbon fixation and protonated RNA interference to healthy longevity.

See also the series from 4/8/20 until 5/10/20 The microRNA-mediated future of humanity

For the link to cancer prevention and/or effective treatment, see: Differential methylation and expression patterns of microRNAs in relation to breast cancer subtypes among American women of African and European ancestry 3/30/21

…altered microRNA (miRNA) expression, may contribute to racial differences in breast cancer.

The link from microRNA-mediated sex differences in phenotypes extends to ethnic diversity outside the context of pseudoscientific nonsense. Social scientists, mathematicians, and theoretical physicists are not serious serious scientists unless they have linked quantum coherence to coherently organized biology.

See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20

…naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.

If the lives of black women, or the lives of any other men or women mattered to people like this, they would tell the truth and link God’s Creation of energy-as-information from Darwin’s studies of pigeons to ethnic differences in cancer via nutrient-dependent pheromone-controlled genetic processes of reproduction in species of soil bacteria to humans.

To link one biophysically constrained amino acid from Darwin’s “conditions of life” to all biodiversity on Earth via the physiology of reproduction in Biblical Genesis, see: Genomic diversity and evolution of the head crest in the rock pigeon 1/31/13

This identified one gene with genome-wide significance: EphB2, and specifically the cr SNP (Pgenome = 2.0×10−8) (Fig. 2C,D). The cr allele has a predicted charge-changing arginine (basic) to cysteine (polar uncharged) transition in the catalytic loop of the intracellular tyrosine kinase domain of EphB2 (Fig. 2E). This amino acid position is invariant among other vertebrates suggesting strong purifying selection for conserved protein function. Notably, the same DLAARN to DLAACN motif change we observe in EphB2 is sufficient to abrogate kinase activity in human and mouse orthologs of the protein tyrosine kinase ZAP-70, and in both mammals and pigeons the mutant phenotypes are inherited recessively (). Hence, the pigeon cr mutation probably abrogates kinase activity in EphB2 and disrupts downstream signal propagation, consistent with the high VAAST score for this gene. EphB2 is therefore a convincing candidate for the cr locus of classical pigeon genetics (, ).

 

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