The alphavirus 3′-nontranslated region: size heterogeneity and arrangement of repeated sequence elements 1/5/98

The 19-nt conserved sequence element directly adjacent to the poly(A) tract was found in all viruses

The 19-nt conserved sequence element is biophysically constrained across kingdoms. No experimental evidence of top-down energy-dependent causation suggests that this 19-nt conserved sequence evolved via natural selection for mutations during billions to millions of years.

For comparison, the conservation of one 22-nucleotide ring was reported in Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20

Gene-centric theories failed to include facts about the energy-dependent conservation of the 19-nt sequence element and the 22 nucleotide RNA ring. They also ignored the fact that their stupid theories began to be eliminated by intelligent serious scientists in 1999.

See: Gene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses 7/1/99

…post-transcriptional gene silencing of nuclear genes is a manifestation of a natural defense mechanism that is induced by a wide range of viruses.

See also: Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication 1/31/18

Reported as: ID’ing Features of Flu Virus Genome May Help Target Surveillance for Pandemic Flu 1/31/18

Moving forward, learn how SARS-CoV-2 was created in the Wuhan lab.

The proximal origin of SARS-CoV-2 3/17/20

…the spike protein of SARS-CoV-2 has a functional polybasic (furin) cleavage site at the S1–S2 boundary through the insertion of 12 nucleotides, which additionally led to the predicted acquisition of three O-linked glycans around the site.

The creation of SARS-CoV-2 in the lab was reported as: The COVID-19 coronavirus epidemic has a natural origin, scientists say 3/17/20

The article and the report pit the ability of Edward C. Holmes to obfuscate facts about biophysically constrained viral endemicity against the claims of those who know how natural selection for food energy-dependent codon optimality is linked from RNA interference to healthy longevity across kingdoms.

Thank God, the Committee on Oversight and Reform has finally caught up to Holmes and others like him.

Dear Dr. Holmes:
We are conducting oversight of the U.S. government’s response to the ongoing COVID-
19 pandemic, and specifically apparent conflicts of interest, suppression of scientific discourse,
and abuse of official government resources.

Q: What took them so long?