Predicting who wins the 2017 Nobel Prizes (3)
(click to enlarge)
Summary: The unique mechanism detailed in the context of “Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression ” is obviously not a unique mechanism. The mechanism exemplifies the fact that RNA-directed DNA methylation is energy-dependent and the fact that virus-driven energy theft causes the degradation of messenger RNA, which serious scientists have linked to all pathology.Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression in the context of my blog post about Viral infection linked to cancer via a “unique mechanism,” which was reported as: “Unique mechanism links viral infection by HPV with cancer through function of a single enzyme ”
The so-called unique mechanism is obviously the virus-driven degradation of messenger RNA, which has repeatedly been linked to all pathology, including the suicides of veterans who have served overseas.
See also experimental evidence of virus-driven degradation portrayed in the 2 October 2017 publication: Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability
Drosophila embryos with trr alleles encoding catalytic mutants manifest subtle developmental abnormalities when subjected to temperature stress or altered cohesin levels. Collectively, our findings suggest that animal development can occur in the context of Trr or mammalian COMPASS-like proteins deficient in H3K4 monomethylation activity and point to a possible role for H3K4me1 on cis -regulatory elements in specific settings to fine-tune transcriptional regulation in response to environmental stress.
The ability to fine-tune transcriptional regulation via energy-dependent changes in RNA-directed DNA methylation was reported as: Unexpected findings uncover new understanding of gene expression
“What is it about the whole body of the enzyme itself that functions in development and its mutations that can result in cancer? That’s what we need to figure out.”
Thanks for asking. The unique mechanism detailed in the context of Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression is obviously not a unique mechanism. The mechanism exemplifies the fact that RNA-directed DNA methylation is energy-dependent and the fact that virus-driven energy theft causes the degradation of messenger RNA, which serious scientists have linked to all pathology.microRNA or pre mrna .VIDEO
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5
0
Energy-dependent RNA methylation (1)
6
0
Secular humanism and ecoterrorism
4
0
Thermotolerance and longevity (2)
3
0
War Games: False Flag Terrorism
5
0
Energy-dependent biodiversity (2)
2
0
The tipping point? 50,000 publications (3)
6
0
Neo-Darwinism failed in 1995
3
0
Countdown to Genetics and Genomics
< 1
0
Energy-dependent creation and entropy
4
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7
0
RNA-mediated physics, chemistry, and molecular epigenetics
9
0
MicroRNAs and/or QTLs: Who buried what?
2
0
RNA splicing, genetic variation, and disease
2
0
Wasted Templeton Funding (3)
2
0
Wasted Templeton Funding (2)
2
0
Millions of water molecules vs years of evolution
2
0
A bumper crop of virus-infected weeds and people
2
0
From nothing to life and death everywhere
5
0
Molecular Diagnostics: What is unprotected life (4)
2
0
Molecular Diagnostics: What is unprotected life (3)
5
0
Molecular Microbial Ecology
8
0
Molecular Diagnostics: What is unprotected life? (2)
7
0
Molecular Diagnostics: What is unprotected life?
2
0
Virus-driven sex differences?
2
0
Creating and/or programming the immune system
< 1
0
Half truths support theories without facts
4
0
Ricki Lewis’ Time Machine (3)
5
0
Creating nutrient-dependent life with enough genes to survive
3
0
Confusing effects and affects of visual input
2
0
Selective reporting of inferences: examples of pseudoscience
14
0
Ignore the evidence: Rachel Feltman
5
0
Virus-driven disorder prevention and health promotion
6
0
Stress-linked population-level history dependence
5
0
Do not miss the misrepresentations
2
0
Energy dependent RNA-mediated immunity (3)
8
0
RNA-mediated DNA modifications
5
0
Science vs semantics
4
0
From angstroms to ecosystems and entropy
2
0
Bacteria see the light and they adapt (2)
5
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3
0
Effects on invertebrate GnRH and affects on primate behavior
6
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2
0
Hydrogen-atom transfer in DNA base pairs (7)
5
0
Organic Compounds and the Miracle of Smell and Taste
7
0
Neuroscience Virtual Event vs AAAS Symposium
3
0
Cancer: Evolution 2.0’s Blind Spot
13
0
Ricki Lewis’ Time Machine (2)
6
0
Hydrogen-atom transfer in DNA base pairs (6)
7
0
Center stage RNA-mediated events (since 1996)
3
0
Blood test links atoms to ecosystems
2
0
Teleophobes vs teleophiles: a recent history
2
0
Ecological genomics: teleophobes respond (too late)
10
0
Ecological law, cooperation, and DNA repair
4
0
Genes, orchid odors, and pheromones from blonds
5
0
Amino acid substitutions, stress, and human behavior
3
0
Finding peace and π in the light of H bond energy (2)
8
0
MicroRNA-mediated RNA epigenetics
2
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3
0
Finding peace and π in the light of H bond energy
5
0
Perry Marshall: too much information for atheist PZ Myers
3
0
Assumptions prove ignorance (2)
5
0
Epigenetic (re)programming of behavior
4
0
Assumptions prove ignorance
5
0
Neo-Darwinian sink testing
2
0
NORAD: air defense and defense against genomic entropy
7
0
Life history transitions and RNA-mediated survial
2
0
Did Dobzhansky see the UV light of creation?
10
0
Researchers rename, reshuffle, and reveal their ignorance
3
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5
0
Does metabolism link beneficial mutations to cancer?
10
0
Manufacturing fossil “evidence”
4
0
RNA-mediated theory killers (4)
9
0
RNA-mediated theory killers (5)
2
0
RNA-mediated theory killers (3)
7
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5
0
RNA-mediated theory killers
6
0
Natural cooperation and Evolution 2.0
6
0
A two-faced protein enables RNA-mediated DNA repair (4)
6
0
A two-faced protein enables RNA-mediated DNA repair (5)
4
0
A two-faced protein enables RNA-mediated DNA repair (3)
8
0
A two-faced protein enables RNA-mediated DNA repair (2)
4
0
Sulfated steroids and RNA-mediated identity codes
< 1
0
Neo-Darwinism vs the neocortex
4
0
Life and death predicted by DNA methylation
3
0
Organization of biological sequences
2
0
Virally derived RNA molecules and cell types
2
0
Positive feedback loops and epigenetic traps
2
0
Stress-perturbed mitochondrial dysfunction (2)
5
0
Behavioral Immune System model
4
0
Stress-perturbed mitochondrial dysfunction
4
0
Theorists can’t understand biology
6
0
Neuroplasticity
4
0
Sensationalizing no new mechanism
2
0
Too complex for the Complex Biological Systems Alliance
4
0
Receptor methylation controls behavior
2
0
Virus, transposon and plasmid evolution
< 1
0
Models are not theories (2)
2
0
Models are not theories (1)
2
0
Can veterans and other prisoners escape pseudoscience?
2
0
eQTLs and ecological adaptation
< 1
0
Unraveling the secrets of RNA-mediated events
2
0
RNA central and RNA-mediated.com
6
0
Ecological speciation. Get it, theorists?
< 1
0
Designing, engineering, and protecting biodiversity
3
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
Neo-Darwinian logic is nonsense
3
0
FREE* SAMPLE: Histone modification
4
0
700 million years of evolution?
5
0
Biophysically constrained or unconstrained?
2
0
Mutated mitochondrial genes vs Supercoiled DNA
2
0
Mystery machine vs medical intelligence
2
0
Preventing genomic entropy
4
0
Molecule of life vs animal experiments
< 1
0
Keep the gay gene theory?
< 1
0
Supercoiled DNA constrains virus-driven genomic entropy
2
0
Let there be anti-entropic light (2)
4
0
Nutrient-dependent RNA-directed DNA methylation
5
0
Non-mainstream scientist shares Nobel prize in Medicine
3
0
Is mainstream science in “Science” pseudoscience?
5
0
Theorists have not seen the light
4
0
Exosomes and the RNA-mediated future of medicine
5
0
Phytochemical link from the sun to cell types
2
0
Genome sequencing, cadherins, and quantum consciousness
6
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
The “great filter” is an epigenetic trap
4
0
The stability of organized genomes (3)
3
0
Viruses, amino acids, and somatic cell types (2)
5
0
Picornaviruses moving between primates (or not)
2
0
Riding the wrong direction
3
0
MicroRNA – controlled ecological adaptations
5
0
Becoming biologically informed (2)
3
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4
0
“New” epigenetic mechanism for lifelong learning?
3
0
Is SUMOylation RNA-directed DNA methylation?
2
0
RNA-mediated development (2)
< 1
0
Unknown mechanisms and conclusions
2
0
Alternative splicings: epigenetics meets pharmacogenomics
4
0
Pattern recognition: biogeochemical structure and function
5
0
Viruses and the human-like microbiome
3
0
Informing the biologically uninformed
< 1
0
Ignoring systems complexity (it’s too complicated)
3
0
Virus-driven cancer treatment and prevention
2
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
RNA-mediated silencing of a chromosome
3
0
Amino acid-dependent cell type differentiation
8
0
Silencing genes and serious scientists
3
0
MicroRNAs and memory
< 1
0
Creating nothing but a theory (2)
4
0
Viruses and ecologically adapted animals
2
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Mimicking claims and ignoring facts
4
0
Questions about life’s diversity
21
0
RNA directed DNA methylation and cell types
4
0
From 3-D to epigenetically-effected 4-D genome make-up
5
0
Are viruses microRNAs? (2)
5
0
Sneaking up from behind
4
0
All of “like kind” (Part 2)
2
0
From Hydra to humans vs a Lakatosian research program
4
0
Dual genomes: exposing the evolution industry
5
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3
0
Biologists puzzled by evolved RNAs and decaying DNA
6
0
More than a bag of chemicals?
2
0
RNA eclipses the importance of DNA to cell type differentiation
4
0
Pharmacogenomics
3
0
It’s cell type differention, not cell fate determination (2)
3
0
Are evolutionary theorists 'nob ends'?
5
2
No understanding of biodiversity
2
0
Understanding physical forces of ecological variation and adaptation
< 1
0
Behavioral ecology: please continue to believe in our fantasies
3
0
Color vision refutes the evolutionary dogma of gene duplication
4
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2
0
RNA-mediated cell type differentiation and behavior
3
0
RNA-directed DNA methylation and RNA-mediated events
5
1
Genotype, observed phenotype, and distinctly disordered behaviors
3
0
RNA-mediated ecological adaptation is not evolution
2
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4
0
A relatively young branch of science called epigenetics
4
0
Comparing divergent model organisms
2
1
A microRNA-mediated mechanism that is epigenetically inherited
2
0
Order and disorder: Ecological adaptations not mutations
6
0
microRNAs differentiate neuronal cell types
3
0
microRNAs and species relationships
3
0
Drunks and Monkeys: Pseudoscientific nonsense
2
0
Cell-type differentiation
2
0
Another powerful refutation of mutation-initiated natural selection
4
0
96 fixed amino acid substitutions, not 96 genes
6
0
Alternative splicings (very technical)
2
0
Alzheimer's, microRNAs, and olfaction
< 1
0
Pheromones and cancer
4
0
Constraints on mutational drift
< 1
0
Epigenetic effects underlie sexual preferences IV
< 1
0
The hormone-miRNA axis, life span, and sexual orientation
3
0
MicroRNA binds messenger RNA: Adaptive Evolution
< 1
0
Disorders of development: altered microRNA / messenger RNA balance
< 1
0
Evolution at work sans random mutations
2
0
Sex differences in Alzheimer's and everything else
2
0
(click to enlarge)