My domains may remain in a key position for information dissemination, or they may be placed into the background by Google’s algorithms. In either case, it has become clear that RNA-mediated events link the nutrient-dependent pheromone-controlled physiology of reproduction to biodiversity in species from microbes to man via amino acid substitutions.
Claims by theorists can now be viewed in the context of a model that links biologically-based cause and effect to biophysically constrained cell type differentiation in all genera.
Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.
For comparison, see: Mutation-Driven Evolution
In other words, genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world. In this view of evolution there is no need of considering teleological elements. (p. 199)
See also (posted yesterday, June 29, 2015):
Introduction: Proteins are complex structures folded from a linear strand of amino acids. These structures are involved in almost every process in the cell. In this iBiology talk, Susan Lindquist discusses the incredible diversity of protein structures, the importance of proper protein folding, and the problems that arise when proteins are misfolded.
My comment: Do you think the mutations that link perturbed protein folding to pathology can also be linked to “…the enormous amount of biodiversity in this world” via “biological innovations?” If so, you may also think there is a model of protein folding that links mutations to something besides pathology.
There is no model of biologically-based cause and effect that links mutations to the organized genomes of all genera.
What is the basis for your ridiculous belief in the pseudoscientific nonsense of population genetics?
It is disingenuous for anyone to place protein folding into the context of “music” after the excellent representations of Denis Noble did so in a series of presentations that established the changes required to link physiology to cell type differentiation.