Summary: If the pathway is ancestral, how and when did it evolve to protect species from microbes to humans from the virus-driven degradation of their messenger RNA?
The theorem addresses only the effects of natural selection. Fisher did not directly address any other effect (mutation, genetic drift, environmental change, etc.) as he considered them to be insignificant. Later mathematicians took issue with Fisher’s lack of rigor, some at considerable length. But the omission of the effects of mutation got the most attention.
The effects of mutation are revisited in: Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus
The automagical creation of receptors is an important determinant of viral tropism. A comparison of amino acid frequencies is linked to ecological adaptation in the virus without concern for the fact that all ecological adaptations are quantized energy-dependent. The authors seem to know nothing about the energy-dependent creation of enzymes and receptors.
Again, where did the energy come from for the adaptations to viruses by these organisms? Is the diversity caused by mutations and evolution in:
…fungi, green algae, diatoms, slime molds, oomycetes, dinoflagellates, apicomplexans, kinetoplastids, diplomonads, and trichomonads…
The authors cite: The evolution of RNAi as a defence against viruses and transposable elements. (2009) and claim that the RNAi pathway is “believed to be ancestral to all eukaryotes.”
If the pathway is ancestral, how and when did it evolve to protect species from microbes to humans from the virus-driven degradation of their messenger RNA?
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
Viruses (aka bacteriophages) kill bacteria. That is how they control archaeal dynamics. Viruses steal the quantized energy from bacteria, which causes bacteria to become archaea and cells out walls (L-forms). Bacteria, for comparison, use the sun’s anti-entropic virucidal energy to ecologically adapt. All life on Earth depends on the anti-entropic virucidal energy of sunlight. The virus-driven degradation of messenger RNA links mutations to all pathology. Theorists may be unable to understand that fact, because they never learned how to link sunlight to error-free RNA-mediated DNA repair via endogenous RNA interference.
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes minutes.
Something has gone horribly wrong among pseudoscientists, and that fact is being exposed.
Let’s put this into perspective of the extraordinary example of pseudoscientific nonsense published by researchers at Johns Hopkins who have a “bad luck” theory of cancer.
They published in “Science”. No charges have been filed for discrimination against intelligent serious scientists.