Genotype is a betting and manipulation game about cross-breeding pea plants, as in Gregor Mendel’s famous experiments. Players compete over three generations to predict the traits of new offspring, by controlling the parent plants’ genetic makeup (“genotype”). The offspring are determined by a die-roll at the end of each round and become the starting parents for the next generation. Changing the parent genotypes dramatically alters the likelihood of the offspring genotypes, and players will have to balance betting on outcomes with manipulating their chances for success.
In each round, players take turns placing one of their action cubes, either as a bet, which may earn points for any future generation; or to determine a parent’s genotype in one trait area. If a player matches one of the public genotype goals for a parent, they may receive a special bonus power for the round. They would also receive a parent token, which can be collected for points at end-game scoring.
After three generations, the player with the most points wins!
Darwin knew nothing about genetics but he still got the part right about placing energy-dependent “conditions of life” and parent genotypes before natural selection.
Ecological adaptations start with energy-dependent niche construction.
“If the Gli1-positive cells are eliminated or unable to secrete Wnt proteins, the activation signal is lost. Consequently the colon’s stem cells as well as the epithelium will perish, and the organism dies,” says Basler.
The creation of stem cells is food energy-dependent. All organisms must find food or they die. See for comparison: The Connectomic Revolution What the Insect Brain Can Tell Us About Ourselves
The honeybee model organism of quantized energy-dependent biophysically constrained viral latency is placed into the context of neo-Darwinian evolution.
I tried to dispense with that pseudoscientific nonsense in: Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)
An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.
For the obvious link from ecological adaptations to human consciousness without the nonsense about the evolution of an environmental drive, see:
See also: Molecular Vibration-Sensing Component in Human Olfaction (2013) and this report on the article: Quantum smell (2013)
Most of today’s science news ignores everything known to serious scientists about molecular vibrations and electron spin, which are the links from quantum physics to quantum souls.
I continue to be amazed by the level of ignorance displayed by so-called experts who have fallen decades behind the extant literature. For example, Gene Robinson cited our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation [From fertilization to adult sexual behavior] in Organizational and activational effects of hormones on insect behavior (2000). We included a section on molecular epigenetics and, in 2017 Gene Robinson coauthored: Epigenetics and the evolution of instincts with Andres Barron.
Both these so-called experts seem to think that no one else has learned how my food energy-dependent “plasticity first” model of ecological variation was repeatedly linked from electron spin to ecological adaptation without any nonsense about evolution.
See also: Bodley Head signs ‘Freakonomics-style’ peer-reviews exposé (2018)
Hypeology will explain how “bad practice and dodgy results have become endemic in contemporary science”, and it will provide a “devastating and gripping take-down of the over-simplified way many of us – including scientists – present and interpret even those results that are reliable”. It will also be a “celebration of everything that is great about science
Reliable results that link quantized energy-dependent top-down causation to biophysically constrained viral latency and all biodiversity are now being placed into the context of reports on nonhomologous end joining (NHEJ) to chromosomal rearrangements and the homology‐directed repair (HDR) pathway.
Nothing good can come from this. See: Tiny giants of gene regulation: experimental strategies for microRNA functional studies (2016)
The error‐prone nonhomologous end‐joining pathway (NHEJ) can generate high‐frequency insertion or deletion mutations (indels), which if induced in close proximity or overlapping a miRNA target site, could result in loss of MRE function. Alternatively, if an exogenous ‘donor template’ is provided, the homology‐directed repair (HDR) pathway can be exploited to incorporate or remove specific sequences at precise genomic locations.
Use of the terms and acronyms nonhomologous end‐joining pathway (NHEJ) / homology‐directed repair (HDR) pathway are attacks on the knowledge base of serious scientists. Only pseudoscientists and other biologically uninformed theorists eliminate the need to link quantized energy to all biophysically constrained RNA-mediated DNA repair in the context of what is known about energy-dependent changes in the microRNA/messenger RNA balance that link angstroms to ecosystems in all living genera.