Summary: Genetic mutations do not drive evolution.  Energy-dependent RNA-mediated fixation of amino acid substitutions links the physiology of reproduction to biophysically constrained viral latency.

With minimal effort, you can peruse the science news each day to see how many pseudoscientists report their findings outside the context of food energy-dependent pheromone-controlled biophysically constrained RNA-mediated cell type differentiation.

See for example:

Type 2 diabetes has hepatic origins

The researchers are now working on identifying the endogenous ligand produced by the body, or on developing molecules that could mimic its function.

Clearly, they are aware of the fact that they must link food energy to the endogenous substrate without claiming that gene activation and the creation of the protein automagically occur.

Diabetes, obesity behind 800,000 cancers worldwide: study

“Our study shows that diabetes—either on its own or combined with being overweight—is responsible for hundreds of thousands of cancer cases each year across the world.”

Who did not know that?

New study finds mycobacteria can sense presence of proteins that cause disease

The transcription factor regulates the levels of the protein cargo transported by the machinery. When the bacteria sense the machinery is absent, the levels of the protein substrates are reduced.

Fat distribution in women and men provides clues to heart attack risk

“We hypothesized that there are gender-based differences in body composition and ectopic fat depots and that these could be associated with gender-specific risk profiles for diseases like diabetes, heart disease and stroke,” said lead author Miriam A. Bredella, M.D., radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston.

Sex-differences in cell types link the food energy-dependent pheromone-controlled physiology of reproduction to RNA-mediated cell type stability in all living genera.

Women may be more vulnerable to concussions because of ‘leaner’ nerve fibers

The paper shows us that there is a fundamental, anatomical difference between male and female axons,” Smith said. “In the male axon, there are a great number of microtubules, which make the entire structure stronger, whereas in female axons, it’s more of a leaner type of architecture, so it’s not as strong.

This representation of energy-dependent RNA-mediated cell type differentiation is sexist. If researchers claimed there were racial differences in biophysically constrained cell type differentiation, the claim would be racist.

That’s the problem that all pseudoscientists have with cryo-EM. It makes everything that will be reported in the context of energy-dependent links from electrons to ecosystems appear to be racist in the context of A Civic Biology: Presented in Problems (New York, 1914)

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Exploratory whole-exome analysis revealed higher expression of humanin-like 8 (MTRNR2L8, or HN8) in both suicide and depression (Figure 1, Supplementary Table 2). MTRNR2L8 is an isoform of the humanin gene (HN) (), a newly discovered mitochondrial-derived 24 amino acid peptide (), which is coded by nuclear DNA.

See also:

These effects appear to be driven primarily by depression, with the exception of genes involved in ‘DNA-dependent ATPase activity’, which appear to be greater in suicide but not depression. Results suggest cortical gene expression related to microglial, endothelial and glial cell functions may contribute toward or be altered in MDD and suicide, and identify the putative genes and pathways which may play a functional role in these disorders.

This claim makes it obvious that the researchers do not know the difference between an epigenetic effect on hormones and the affect of hormones on behavior. That explains their failure to link energy-dependent epigenetic effects from ATPase activity to changes in the microRNA/messenger RNA balance. That means they cannot link RNA-mediated differences in the cell types that protect organized genomes from the virus-driven degradation of messenger RNA to mutations and all pathology.

Heat, Hydrogen, and Togas

Ther­mo­to­gae are strict an­aero­bes and gram ne­ga­ti­ve. Their pep­ti­do­gly­can is uni­que in hav­ing as much D-ly­sine as the usu­al L-ly­sine. And, no LPS (or, at least, no LPS-ma­king en­zym­es), de­spi­te be­ing gram-ne­ga­ti­ve.

The stability of all organized genomes is energy-dependent and biophysically constrained by the fixation of amino acid substitutions in organized genomes. The amount of D-ly­sine compared to the amount of L-ly­sine links the dynamic control of chirality to the quantized energy-dependent creation of supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.

 

The fact that hydrogen-atom transfer in DNA base pairs in solution links quantized energy as information from the creation of sunlight to the quality of RNA, which must be linked to energy-dependent DNA repair, seems to have escaped the attention of theorists.

Chemists reveal one mechanism of dihydrogen production by nitrogenase (with my emphasis)

There are 2 types of hydrogens in the catalytic cofactor (called FeMo-co): one located in a bridging position where it binds to two iron atoms (a bridging hydride), and one on a nearby sulfur atom ligands (basically a protonated sulfur atom: S-H). It turns out that during H2 evolution, the latter is the active partner. The S-H bond breaks and the resulting H+ moves toward the bridging hydride and protonates it forming H2: The calculations provide an explanation of the experimental observation that only one hydrogen is “active,” while the other is a mere spectator waiting for the arrival of its partner.
 

Can anyone help to link the calculations to the evolution of the two types of hydrogens in the context of Feynman’s claims about food energy and human idiocy?

A correspondent wrote:

Interesting chirality issues, however I know of no biological system where light directly changes polymer helicity, and this paper is not a biological system. Vines can change their macroscopic helicity, incredibly, just by single amino acid substitutions in different cytoskeltal monomer proteins.

Thanks. A single amino acid substitution at position 6 of the GnRH decapeptide in all vertebrates links the sense of smell in bacteria to the pheromone-controlled physiology of reproduction and all biophysically constrained biodiversity via achiral glycine. 

See also: Photoinduced charge transfer occurs naturally in DNA

Scientists identify the segmentation and consolidation mechanism of long-term memories

According to the research, published in the scientific journal Current Biology, the brain identifies context changes as “frontiers” in the flow of our experience and uses them to fragment the course of events into small units of memory that can be stored long-term. The study shows that this process takes place during the identification of a boundary event thanks to the rapid reactivation of the flow of information that precedes it.

The flow of information is energy-dependent and serious scientists have link the energy-dependent changes from RNA-methylation to RNA-directed DNA methylation and all biodiversity via the pheromone-controlled physiology of reproduction.

The article does not mention RNA-methylation, which means it is a compilation of pseudoscientific nonsense.

See for comparison: Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

The differential effects of m6A may depend on distinct cis-acting elements that are present on the RNA molecule which may interact with m6A, including micro-RNAs (Alarcón et al., 2015; Chen et al., 2015).

When physics gives evolution a leg up by breaking one

Genetic mutation may drive evolution, but not all by itself.

Genetic mutations do not drive evolution.  Energy-dependent RNA-mediated fixation of amino acid substitutions links the physiology of reproduction to biophysically constrained viral latency.

See Schrodinger (1944): and link the anti-entropic virucidal energy of sunlight to all biodiversity via the creation of RNA and the physiology of pheromone-controlled reproduction.

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

See the reprint edition with the forward by Roger Penrose.

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?”(Roger Penrose 8 August 1991)

‘Mind’s eye blink’ proves ‘paying attention’ is not just a figure of speech

Mind’s eye blink is closely related to “attentional blink” that has been studied by Cornelius Vanderbilt Professor of Psychology David Zald and Professor of Psychology René Marois. Attentional blink is a phenomenon that occurs when a person is presented with a rapid series of images. If the spacing between two images is too short, the observer doesn’t detect the second image. In 2005, Zald determined that the time of temporary blindness following violent or erotic images was significantly longer than it is for emotionally neutral images.

Olfaction spontaneously highlights visual saliency map

Fear-related chemosignals modulate recognition of fear in ambiguous facial expressions

Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults

 

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