Can a Quirky Chromosome Create a Second Human Species?

Excerpt 1)

The first departure from the common house mouse (Mus musculus) was the “tobacco mouse” (Mus poschiavinus), described in 1869 from specimens trapped in a tobacco factory in Valle di Poschiavo, Switzerland. They had big heads and small, dark bodies.

Excerpt 2)

I spoke to Bear back in 2004, again for The Scientist (a mechanism for the rapid extinction of a dedicated freelance writer is a change in editor-in-chief). Greg Bear is a self-taught scientist with a soaring imagination. Said he, “My secrets are few. I love biology. I have been researching it in constant reading since the early 1980s. I saw very clearly that DNA must be computational, a self-organizing, self-repairing system. In the early 90s, it became clear to me that modern evolutionary theory was incomplete. I set out to find all the out-of-the-way papers that I could to prove that nature was a network, from top to bottom.” The Darwin series arose from those thoughts…

My comment: As she started to do in her 2004 article in The Scientist, Ricki Lewis has now linked the history of viruses to cell type differentiation across 146 years.

I spoke with Eugene Garfield, the founder of The Scientist in 1995, and mention of my book (co-authored by Robert Francoeur) appeared later that year. I met “Gene” at an invitation-only conference that he funded in its entirety. Ninety experts from all over the world — all expenses paid, with Roger Gorski as the keynote speaker.

Greg Bear was the first to incorporate what is currently known about pheromones and cytogenetics into his works. Eugene Daev, Anna Di Cosmo, and Bruce McEwen are among the others.

Obviously, no one has time to cover all the extant literature. That’s why it’s great that you took a step back in time that will help others move forward when they decide to pursue details about cytogenetics.

See also:

Date: 01/28/2015 From: Steven Taylor
Location: United States
James V. Kohl claims you incorporated his model of nutrient dependent, pheromone ecological adaptation in your Darwin novels. Any truth to that?

Re: James V. Kohl
Date: 01/29/2015
From: Greg Bear
There’s more than a hint of pheromone-HERV and cortico-steroid interaction in DARWIN’S RADIO. And James is certainly a pioneer in the pheromone world! We’ve corresponded for years on these subjects. I’m not sure about the nutrient angle, however. Interesting to follow that track as well!

My comment: Rosalind Franklin’s work with the tobacco mosaic virus may have caused her to question the Watson-Crick model of static DNA.

See: Franklin … spent the last five years of her career elucidating the structure of plant viruses, notably tobacco mosaic virus.

Thankfully, hydrogen-atom transfer in DNA base pairs in solution has since linked the anti-entropic energy of the sun from UV light to RNA-mediated cell type differentiation via the pheromone-controlled physiology of reproduction in species from microbes to humans. The most obvious link is from cytogenetics to RNA-mediated amino acid substitutions via chromosomal rearrangements linked from ecological variation to ecological speciation.

That fact continues to terrorize teleophobic neo-Darwinists who didn’t like what Greg Bear claimed from the time he first began to link viruses to biodiversity in “Blood Music.” When he tried to warn others about the likelihood of virus-driven terrorism, he also was virtually ignored.

Sci-fi author Greg Bear tells Jon about the not-so-distant future of technology and helping Homeland Security. (7:02)

Ricki Lewis will make a welcome addition to the ranks of serious scientists who are Combating Evolution to Fight Disease because she has the background in cytogenetics to help others who may not know how to link atoms to ecosystems.

Her response to my comment:

Thanks so much James. I loved Gene and writing for The Scientist, I did hundreds of articles for them. Has he passed away? There was a rumor and I looked for an obit a few years ago and I found one but I don’t think it was him. What a leader and visionary. I felt like an old fart writing that post but the patient made me realize the limitations of sequencing. I love when genetics makes me think!

My reply:

I met him though an octogenerian psychiatrist turned geneticist who presented on trinucleotide repeats and X-linked sexual orientation. “Bill” was ignored by virtually everyone except Gene and me. I was introduced to Gene the next day when they invited my to join them at breakfast, which is when Gene expressed an interest in my book. I’m certain that no one else but the conference organizers knew Gene was there.

I never saw either of them again. Both provided the extra push that led Teresa Binstock and me to publish “From Fertilization to Adult Sexual Behavior” with Milton Diamond in Hormones and Behavior http://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html

Excerpt: “Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).”

See: Turner, W.J. (1995) Asexuality, homosexuality, and transexuality (abstract) International Behavioral Development Symposium: Biological Basis of Sexual Orientation and Sex Typical Behavior, Minot, ND, May 25- 27, 77.

See also: Primate CpG Islands Are Maintained by Heterogeneous Evolutionary Regimes Involving Minimal Selection

Excerpt:

Epigenetics as a mechanism for emergence of genomic information without selection

My comment: Since 1995, few people besides Greg Bear have realized the significance of anything published about any model organism from yeasts to primates that does not tout “evolutionary regimes” or other inexplicable nonsense. And currently, pseudoscientists are scrambling to avoid questions about weekend evolution of the bacterial flagellum, chromosomal rearrangements, and the stability of organized genomes. Pseudoscientist know the chromosomal rearrangements are neo-Darwinian evolutionary theory killers — as were (or still are) Gene Garfield and my friend “Bill” Turner.

It’s always fascinated me to find others, like Ricki Lewis, who are connected to the extremely intelligent people from my past — especially when they are contributing to a legacy of accurate representations that link atoms to ecosystems via molecular epigenetics, which is what all serious scientists must do.

Trinucleotide repeat expansion 

Excerpt 1)

‘loop out’ structures may form during DNA replication while maintaining complementary base pairing between the parent strand and daughter strand being synthesized.

Excerpt 2)

Other proposed mechanisms for expansion and reduction involve the interaction of RNA and DNA molecules.[3]

The number of trinucleotide repeats appears to predict the progression, severity, and age of onset of Huntington’s disease and similar trinucleotide repeat disorders.[4]

My comment: Despite everything currently known about the nutrient-dependent pheromone-controlled interaction of RNA and DNA molecules, pseudoscientists refuse to abandon their ridiculous theories about beneficial mutations and/or natural selection and evolution.

In the latest edition of their story-telling, they have decided to claim “…we can’t say for sure there is no difference in methylation between queens and workers. What our study does show is that the current evidence is inconclusive.” — New study challenges popular explanation for why a social insect becomes a worker or queen

Serious scientists will recognize this as yet another attempt to undermine the entirety of what they have done to link atoms to ecosystems in all living genera via energy-dependent hydrogen-atom transfer in DNA base pairs. And, someday, Ricki Lewis or someone like her will write a story that links microbes to humans via the honeybee model organism.

See for example: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

Excerpt:

Animal models are often used to model human physical and mental disorders. The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of the X chromosome, learning and memory, as well as conditioned responses to sensory stimuli (Kohl, 2012).

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